Dilated cardiomyopathy causes: Difference between revisions

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Revision as of 15:52, 20 October 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-in-Chief: Sachin Shah, M.D.

Overview

There are many causes of dilated cardiomyopathy. The most common cause is idiopathic in 50% of cases. The next most common cause is myocarditis which is responsible for 10% of cases. The high percentage of idiopathic dilated cardiomyopathy may be related to the difficulty in diagnosing viral myocarditis. Other common causes include substance abuse, connective tissue disease, pregnancy, medications, nutritional deficiencies, infiltrative diseases and toxins. There are varying degrees of severity of the disease. Some forms are reversible and some are irreversible; some patients may be completely asymptomatic and some may require cardiac transplantation.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Carbon monoxide poisoning

Common Causes

Causes by Organ System

Cardiovascular	Alstrom syndrome, amyloidosis, Carvajal-Huerta syndrome, coronary artery disease, endocardial fibroelastosis, eosinophilic cardiomyopathy, hemochromatosis, hypersensitivity myocarditis, hypertension, hypertensive heart disease, ischemic cardiomyopathy, ischemic heart disease, Kawasaki disease, myocarditis, myxoma, peripartum cardiomyopathy, rheumatic fever, Salih myopathy, tachycardia, x-linked dilated cardiomyopathy
Chemical/Poisoning	Beryllium, carbon monoxide poisoning, cobalt, ethanol, heavy metals, lead, mercury, selenium, toxins
Dental	No underlying causes
Dermatologic	Carvajal-Huerta syndrome, dermatomyositis, familial cutaneous collagenoma, scleroderma
Drug Side Effect	Adriamycin, amphetamines, anthracyclines, antiretroviral drugs, bleomycin, certolizumab pegol,chemotherapeutic agents, chloroquine, clozapine, cyclophosphamide , didanosine, disopyramide, doxorubicin, epirubicin, idarubicin, imatinib mesylate, lithium , methysergide, mitoxantrone, paracetamol, peplomycin, phenothiazines, tacrolimus, trastuzumab, zalcitabine, zidovudine
Ear Nose Throat	No underlying causes
Endocrine	Acromegaly, amyloidosis, Cushing's syndrome, diabetes mellitus, hemochromatosis, hyperparathyroidism, hypoparathyroidism, hypothyroidism, myxedema, pheochromocytoma, pituitary tumor
Environmental	Heat stroke
Gastroenterologic	Hemochromatosis, sarcoidosis, Whipple's disease
Genetic	Alstrom syndrome, Barth syndrome, Becker muscular dystrophy, desmin-related myopathy, Duchenne's muscular dystrophy, Emery-Dreifuss muscular dystrophy, X-linked, Erb dystrophy, Fabry's disease, familial cutaneous collagenoma, Friedreich's ataxia, hemochromatosis, Laing distal myopathy, limb girdle muscular dystrophy, McLeod neuroacanthocytosis syndrome, McLeod phenotype, Naxos disease, Salih myopathy
Hematologic	Hemochromatosis, McLeod neuroacanthocytosis syndrome, McLeod phenotype
Iatrogenic	Radiation
Infectious Disease	Adenovirus, brucellosis, Chagas disease, Coxsackie virus, cryptococcosis, cytomegalovirus, diphtheria, echovirus, Epstein-Barr virus, hepatitis, histoplasmosis, HIV infection, influenza virus, leptospirosis, Loa loa, Lyme disease, myocarditis, parvovirus, psittacosis, rheumatic fever, schistosomiasis, syphillis, toxoplasmosis, trichinosis, trypanosomiasis, typhoid fever, varicella
Musculoskeletal/Orthopedic	Becker muscular dystrophy, desmin-related myopathy, Duchenne's muscular dystrophy, Emery-Dreifuss muscular dystrophy, X-linked, Erb dystrophy, hemochromatosis, Laing distal myopathy, limb girdle muscular dystrophy, myotonic dystrophy, rheumatoid arthritis, Salih myopathy
Neurologic	Friedreich's ataxia, giant cell arteritis, Refsum's disease, sleep apnea
Nutritional/Metabolic	Beriberi, carnitine, Fabry's disease, glycogenosis type 2b, hypocalcemia, hypophosphatemia, isobutyryl-CoA dehydrogenase deficiency, niacin, nutritional deficiencies, pellagra, Refsum's disease, thiamine, triosephosphate isomerase deficiency
Obstetric/Gynecologic	Childbirth, pregnancy
Oncologic	Myxoma, pheochromocytoma, pituitary tumor
Ophthalmologic	Giant cell arteritis
Overdose/Toxicity	Alcohol abuse, cocaine, substance abuse
Psychiatric	No underlying causes
Pulmonary	Sarcoidosis
Renal/Electrolyte	Uremia
Rheumatology/Immunology/Allergy	Amyloidosis, connective tissue disease, dermatomyositis, giant cell arteritis, rheumatic fever, rheumatoid arthritis, sarcoidosis, scleroderma, serum sickness, systemic lupus erythematosis, transplant rejection
Sexual	No underlying causes
Trauma	Electric shock
Urologic	No underlying causes
Miscellaneous	Heat stroke, hypothermia , idiopathic

Causes in Alphabetical Order

References

↑ Felker GM, Thompson RE, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med 2000 Apr 13;342(14):1077-84.

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[1] Felker GM, Thompson RE, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N Engl J Med 2000 Apr 13;342(14):1077-84.

[1]

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 *[[Selenium deficiency]]
 *[[Substance abuse]]
-*[[Toxins]] (such as
+*[[Toxins]]
 *[[Trastuzumab]]
 *[[dilated cardiomyopathy|X-linked dilated cardiomyopathy]]