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Substance/Medication-Induced Depressive Disorder

Diagnostic Criteria

DSM-V Diagnostic Criteria for Substance/Medication-Induced Depressive Disorder

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• A.A prominent and persistent disturbance in mood that predominates in the clinical picture and is characterized by depressed mood or markedly diminished interest or pleasure in all, or almost all, activities.

AND

• B.There is evidence from the history, physical examination, or laboratory findings of both

(1)and(2):

• 1.The symptoms in Criterion A developed during or soon after substance intoxication or withdrawal or after exposure to a medication.
• 2.The involved substance/medication is capable of producing the symptoms in Criterion A.
• C.The disturbance is not better explained by a depressive disorder that is not substance/medication-induced. Such evidence of an independent depressive disorder could include the following:

The symptoms preceded the onset of the substance/medication use; the symptoms persist for a substantial period of time (e.g., about 1 month) after the cessation of acute withdrawal or severe intoxication; or there is other evidence suggesting the existence of an independent non-substance/medication-induced depressive disorder (e.g., a history of recurrent non-substance/medication-related episodes).

AND

• D.The disturbance does not occur exclusively during the course of a delirium.

AND

• E.The disturbance causes clinically significant distress or impairment in social, occupational,or other important areas of functioning.

Note:This diagnosis should be made instead of a diagnosis of substance intoxication or substance withdrawal only when the symptoms in Criterion A predominate in the clinical picture and when they are sufficiently severe to warrant clinical attention. .

Epidemiology and Demographics

Prevalence

The prevalence of substance/medication-induced depressive disorder is 260 per 100,000 (0.26%) of the overall population.

Risk Factors

• Antisocial behavior
• Alcohol or drug use disorders
• History of drug induced depression
• Higher family history of substance use disorders
• History of stressful life events
• Major depressive disorder
• Psychosocial stressors
• Specific type of medication

Differential Diagnosis

• Depressive disorder due to another medical condition
• Primary depressive disorder
• Substance intoxication and withdrawal

Depressive Disorder Due to Another Medical Condition

Diagnostic Criteria===

DSM-V Diagnostic Criteria for Depressive Disorder Due to Another Medical Condition ===

“

A.A prominent and persistent period of depressed mood or markedly diminished interest or pleasure in all, or almost all, activities that predominates in the clinical picture. AND B.There is evidence from the history, physical examination, or laboratory findings that the disturbance is the direct pathophysiological consequence of another medical condition. AND C.The disturbance is not better explained by another mental disorder (e.g., adjustment disorder, with depressed mood, in which the stressor is a serious medical condition). AND D.The disturbance does not occur exclusively during the course of a delirium. AND E.The disturbance causes clinically significant distress or impairment in social, occupational,or other important areas of functioning. References

”

Risk Factors

• CVA

• Left frontal strokes

Differential Diagnosis

• Adjustment disorders

• Depressive disorders not due to another medical condition

• Medication-induced depressive disorder

• Alpha-interferon

• steroids