Substance or medication induced psychotic disorder

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Synonyms and keywords: Medication induced psychotic disorder; substance induced psychotic disorder; substance-medication induced psychotic disorder

Differential Diagnosis

• Alcohol withdrawal
• Brief psychotic disorder
• Cannabis intoxication
• Delusional disorder
• Flashback hallucinations
• Intoxication with stimulants
• Phencyclidine
• Schizophrenia
• Schizoaffective disorder
• Schizophrenia spectrum
• Delusional disorder
• Opioid meperidine

Epidemiology and Demographics

Prevalence

The prevalence of substance/medication-induced psychotic disorder is unknown of the overall population.

Risk Factors

• Cocaine usage
• Heavy and constant ingestion of alcohol
• History of psychopathic disorder

Natural History, Complications and Prognosis

Poor prognosis factors include:

• Depersonalization
• Flashbacks
• Hallucinations
• Marked anxiety
• Persecutory delusions

Diagnostic Criteria

• A. Presence of one or both of the following symptoms:

1. Delusions

2. Hallucinations

AND

• B. There is evidence from the history, physical examination, or laboratory findings of both (1) and (2):

1. The symptoms in Criterion A developed during or soon after substance intoxication or withdrawal or after exposure to a medication.

2. The involved substance/medication is capable of producing the symptoms in Criterion A.

AND

• C. The disturbance is not better explained by a psychotic disorder that is not substance/medication-induced. Such evidence of an independent psychotic disorder could include the following:

The symptoms preceded the onset of the substance/medication use; the symptoms persist for a substantial period of time (e.g., about 1 month) after the cessation of acute withdrawal or severe intoxication: or there is other evidence of an independent non-substance/medication-induced psychotic disorder (e.g., a history of recurrent non-substance/medication-related episodes).

AND

• D. The disturbance does not occur exclusively during the course of a delirium.

AND

• E. The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

Note: This diagnosis should be made instead of a diagnosis of substance intoxication or substance withdrawal only when the symptoms in Criterion A predominate in the clinical picture and when they are sufficiently severe to warrant clinical attention.