Prednisolone (injection): Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Gerald Chi (talk | contribs)
CMEAdmin, Bureaucrats, bureaucrats, editnews, exportpages, interwiki, nocaptcha, nukepages, smwadministrator, Administrators, Widget editors
17,702 edits
No edit summary
Gerald Chi (talk | contribs)
CMEAdmin, Bureaucrats, bureaucrats, editnews, exportpages, interwiki, nocaptcha, nukepages, smwadministrator, Administrators, Widget editors
17,702 edits
mNo edit summary
Line 8: Line 8:
|alcohol=Alcohol-Prednisolone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|alcohol=Alcohol-Prednisolone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
}}
}}
{{drugbox
| IUPAC_name = 11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydrocyclopenta [a]phenanthren-3-one
| image = Prednisolone-2D-skeletal.png
| CAS_number = 50-24-8
| ATC_prefix = A07
| ATC_suffix = EA01
| ATC_supplemental = {{ATC|C05|AA04}}, {{ATC|D07|AA03}}, {{ATC|D07|XA02}}, {{ATC|H02|AB06}}, {{ATC|R01|AD02}}, {{ATC|S01|BA04}}, {{ATC|S01|CB02}}, {{ATC|S02|BA03}}, {{ATC|S03|BA02}}
| PubChem = 5755
| DrugBank = APRD00197
| C=21 | H=28 | O=5
| molecular_weight = 360.444 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life = 2-3 hours
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
| routes_of_administration =
}}
{{SI}}
{{CMG}}
{{EH}}
'''Prednisolone '''is the active metabolite of [[prednisone]].
Prednisolone has an extremely [[bitter]] taste that makes it difficult to administer to children.
==Uses==
It is a [[corticosteroid]] drug with predominantly [[glucocorticoid]] and low [[mineralocorticoid]] activity, making it useful for the treatment of a wide range of inflammatory and [[auto-immune]] conditions such as [[asthma]], [[rheumatoid arthritis]], [[Ulcerative Colitis]] and [[Crohn's disease]], [[multiple sclerosis]], [[cluster headaches]] and [[Systemic Lupus Erythematosus]]. It can also be used as an [[immunosuppressive]] drug for [[organ transplants]] and in cases of adrenal insufficiency ([[Addison's]]).
Prednisolone acetate ophthalmic suspension is an adrenocortical steroid product prepared as a sterile ophthalmic suspension, used to reduce swelling, redness, itching, and allergic reactions affecting the eye.
Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
There is no generally-accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A<sub>2</sub> inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A<sub>2</sub>.
Corticosteriods are capable of producing a rise in intraocular pressure.
==Possible Side-Effects==
Possible side-effects include fluid retention of the face (moon face, [[Cushing's syndrome]]), [[acne]], [[constipation]], and [[mood swings]].  A lengthy course of prednisolone can cause bloody or black tarry stools; filling or rounding out of the face; muscle cramps or pain; muscle weakness; nausea; pain in back, hips, ribs, arms, shoulders, or legs; reddish-purple lines on arms, face, legs, trunk or groin; thin and shiny skin; unusual bruising; urinating at night; rapid weight gain; and wounds that will not heal.  Swelling of the pancreas has also been reported.  Other effects include decreased or blurred vision, increased thirst, confusion, and nervousness. It also is reported to cause insomnia when large strengths, or large doses are taken.
Systemically: Posterior subcapsular cataracts & [[papilledema]]
Topical: PSC & [[glaucoma]]
[[Contraindicated]] with [[herpes]]
==Banned Status in Athletics==
As a glucocorticosteroid, prednisolone is banned under [[WADA]] anti-doping rules.
[[Category:Glucocorticoids]]
{{Corticosteroids}}
{{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}}
{{Vasoprotectives}}
{{Corticosteroids for systemic use}}
{{Nasal preparations}}
{{Otologicals}}
<br>
[[de:Prednisolon]]
[[es:Prednisolona]]
[[fr:Prednisolone]]
[[ko:프레드니솔론]]
[[hu:Prednizolon]]
[[ja:プレドニゾロン]]
[[pl:Prednizolon]]
[[pt:Prednisolona]]
[[ru:Преднизолон]]
{{WH}}
{{WS}}
{{jb1}}

Revision as of 17:28, 2 December 2014

Prednisolone (injection)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Prednisolone (injection) is {{{aOrAn}}} {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. Common adverse reactions include {{{adverseReactions}}}.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Prednisolone (injection) FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Prednisolone in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisolone in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Prednisolone (injection) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Prednisolone in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Prednisolone in pediatric patients.

Contraindications

There is limited information regarding Prednisolone (injection) Contraindications in the drug label.

Warnings

There is limited information regarding Prednisolone (injection) Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Prednisolone (injection) Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Prednisolone (injection) Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Prednisolone (injection) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Prednisolone (injection) in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Prednisolone (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Prednisolone (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Prednisolone (injection) in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Prednisolone (injection) in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Prednisolone (injection) in geriatric settings.

Gender

There is no FDA guidance on the use of Prednisolone (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Prednisolone (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Prednisolone (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Prednisolone (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Prednisolone (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Prednisolone (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Prednisolone (injection) Administration in the drug label.

Monitoring

There is limited information regarding Prednisolone (injection) Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Prednisolone (injection) and IV administrations.

Overdosage

There is limited information regarding Prednisolone (injection) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Prednisolone (injection) Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Prednisolone (injection) Mechanism of Action in the drug label.

Structure

There is limited information regarding Prednisolone (injection) Structure in the drug label.

Pharmacodynamics

There is limited information regarding Prednisolone (injection) Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Prednisolone (injection) Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Prednisolone (injection) Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Prednisolone (injection) Clinical Studies in the drug label.

How Supplied

There is limited information regarding Prednisolone (injection) How Supplied in the drug label.

Storage

There is limited information regarding Prednisolone (injection) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Prednisolone (injection) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Prednisolone (injection) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Prednisolone (injection) Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Prednisolone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Prednisolone (injection) Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Prednisolone (injection) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Retrieved from "https://www.wikidoc.org/index.php?title=Prednisolone_(injection)&oldid=1044368"