Sodium bicarbonate

Sodium bicarbonate
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

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Overview

Sodium bicarbonate is a antacid that is FDA approved for the treatment of relieves acid indigestion, heartburn, Sour stomach, upset stomach associated with these symptoms. Common adverse reactions include {{{adverseReactions}}}.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Relieves

• Acid indigestion
• Heartburn
• Sour stomach
• Upset stomach associated with these symptoms

Dosage

Adults 60 years of age and over: 1-2 tablets every 4 hours, not more than 12 tablets in 24 hours

• Adults under 60 years of age: 1-4 tablets every 4 hours, not more than 24 tablets in 24 hours
• Do not use the maximum dosage for more than 2 weeks
• Tablets may be swallowed whole or dissolved in water prior to use

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Indications and Dosing

• Sodium bicarbonate 84 mg is equal to 1 mEq each of both sodium and bicarbonate.
• 178 mg of sodium per tablet; effervescent contains 770 mg of sodium per capful.
• Cardiac arrest, Due To Hyperkalemia: 50 mEq IV over 5 minutes (guideline dosing).
• Diabetic ketoacidosis: 100 mmol (2 ampules) in 400 mL sterile water for injection with 20 mEq potassium chloride IV at a rate of 200 mL/hr for 2 hours until the venous pH is greater than 7; if pH remains less than 7, repeat infusion every 2 hours until pH is greater than 7 (guideline dosing).
• Indigestion: 1 to 4 tablets ORALLY every 4 hours; MAX 24 tablets/24 hours OR 1 to 2 heaping capfuls in one-half glass of cool water ORALLY while effervescing, once every hour; MAX 6 capfuls/24 hours.
• Indigestion: (60 years or older) 1 to 2 tablets every 4 hours: MAX 12 tablets/24 hours OR 1/2 to 1 heaping capful in one-half glass of cool water ORALLY while effervescing once every hour; MAX 3 capfuls/24 hours.
• Metabolic acidosis, Chronic: initial, 600 mg ORALLY 3 times daily; increase to maintain serum bicarbonate level at 23 mmol/L or greater (clinical trial dosing).
• Toxicity of drug: 1 mL/kg (8.4% solution, 1 mEq/mL) IV bolus, repeat as needed until hemodynamic stability is restored and QRS duration is 120 millisecond or less (guideline dosing).

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Sodium bicarbonate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Sodium bicarbonate FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Sodium bicarbonate in pediatric patients.

Contraindications

There is limited information regarding Sodium bicarbonate Contraindications in the drug label.

Warnings

Ask a doctor before use if you have a sodium restricted diet

Ask a doctor or pharmacist before use of you are

Taking a prescription drug. Antacids may interact with

certain prescription drugs.

Stop use and ask a doctor if symptoms last more than 2 weeks

If pregnant or breast-feeding, ask a health professional before use.

• This package for households without young children. This package is intended for in-patient institutional use only. This package is not child resistant.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Sodium bicarbonate Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Sodium bicarbonate Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Sodium bicarbonate Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Sodium bicarbonate in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Sodium bicarbonate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Sodium bicarbonate during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Sodium bicarbonate in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Sodium bicarbonate in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Sodium bicarbonate in geriatric settings.

Gender

There is no FDA guidance on the use of Sodium bicarbonate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Sodium bicarbonate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Sodium bicarbonate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Sodium bicarbonate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Sodium bicarbonate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Sodium bicarbonate in patients who are immunocompromised.

Others

Administration and Monitoring

Administration

There is limited information regarding Sodium bicarbonate Administration in the drug label.

Monitoring

There is limited information regarding Sodium bicarbonate Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Sodium bicarbonate and IV administrations.

Overdosage

There is limited information regarding Sodium bicarbonate overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Sodium bicarbonate Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Sodium bicarbonate Mechanism of Action in the drug label.

Structure

There is limited information regarding Sodium bicarbonate Structure in the drug label.

Pharmacodynamics

There is limited information regarding Sodium bicarbonate Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Sodium bicarbonate Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Sodium bicarbonate Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Sodium bicarbonate Clinical Studies in the drug label.

How Supplied

There is limited information regarding Sodium bicarbonate How Supplied in the drug label.

Storage

• Store at room temperature 15o - 30o C (59o - 86o F)

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Sodium bicarbonate Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Sodium bicarbonate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Sodium bicarbonate Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Sodium bicarbonate Look-Alike Drug Names in the drug label.

Drug Shortage Status

Drug Shortage

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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