Weight gain causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Causes

Common Causes

• Binge eating
• Body building
• Congestive heart failure
• Depression
• Diabetes
• Hypothyroidism
• Normal growth
• Overeating
• Renal failure
• Selective serotonin reuptake inhibitors (SSRIs)
• Smoking cessation
• Steroids

Causes by Organ System

Cardiovascular	Alstrom syndrome, Heart failure, Simpson-Golabi-Behmel syndrome, Preeclampsia, Beckwith-Wiedemann syndrome
Chemical / poisoning	No underlying causes
Dermatologic	Hypertrichosis brachydactyly obesity and mental retardation, HAIR-AN Syndrome
Drug Side Effect	4-Chlorodehydromethyltestosterone, Aldesleukin, Amiodarone, Amisulpride, Amitriptyline, Anastrozole, Aripiprazole, Asenapine, Atenolol, Azelastine, Bisoprolol, Bosentan, Carteolol, Carvedilol, Chlorpropamide, Chlorprothixene, Ciprofloxacin, Clomiphene, Clomipramine, Clozapine, Combined oral contraceptive pill, Cyclosporine, Cyproheptadine, Cyproterone, Danazol, Desonide, Desoximetasone, Dexamethasone, Diclofenac, Dienogest, Diflunisal, Disopyramide, Docetaxel, Doxazosin, Doxepin, Doxorubicin Hydrochloride, Escitalopram, Estradiol valerate and estradiol valerate/dienogest, Estrogen Injection, Ethinylestradiol, Etodolac, Fenoprofen, Fentanyl, Fludrocortisone acetate, Gabapentin, Gestrinone, Glatiramer, Glucocorticoid, Goserelin, Haloperidol, Hormone replacement therapy, Hydralazine, Hydrochlorothiazide, Hydrocortisone, Iloperidone, Imatinib, Imipramine, Implanon, Indomethacin, Insulin, Interferon beta-1a, Interferon beta-1b, Itraconazole, Ketorolac, Ketotifen, Labetalol, Levobunolol, Levomepromazine, Lithium, Lofepramine, Maprotiline, Meclofenamate, Medroxyprogesterone, Mefenamic acid, Megestrol, Meglitinide, Mesoridazine, Methylprednisolone, Metoprolol, Mianserin, Minoxidil, Misoprostol, Nabumetone, Nadolol, Nialamide, Norplant, NuvaRing, Olanzapine, Oprelvekin, Oxandrolone, Oxcarbazepine, Oxymetholone, Paliperidone, Paroxetine, Perphenazine, Phenelzine, Phenothiazine, Pindolol, Pioglitazone, Piroxicam, Pizotifen, Prednisolone, Pregabalin, Progesterone, Propranolol, Quetiapine, Ractopamine, Reserpine, Risperidone, Rituximab, Rofecoxib, Rosiglitazone, Salsalate, Sargramostim, Selective serotonin reuptake inhibitors, Sertindole, Sertraline, Sirolimus, St John's wort, Steroid medications, Sulfonylureas, Sulindac, Sunitinib, Temozolomide, Terazosin, Thiazolidinedione, Thioridazine, Thiothixene, Timolol, Trazodone, Trestolone, Tretinoin, Triamcinolone oral, Tricyclic antidepressants, Trifluoperazine, Trifluperidol, Valproic acid, Venlafaxine, Vigabatrin, Ziprasidone, Zotepine
Ear Nose Throat	Metaphyseal dysostosis mental retardation conductive deafness, Ayazi syndrome, 1p36 deletion syndrome, Alstrom syndrome, Beckwith-Wiedemann syndrome, Wolfram syndrome
Endocrine	Achard-Thiers Syndrome, Acromegaly, Anophthalmia-short stature-obesity, Cushing's syndrome, Diabetes mellitus, Froelich's syndrome, Growth hormone deficiency, Growth Hormone Receptor Deficiency, HAIR-AN Syndrome, Hashimoto's thyroiditis, Hyperpituitarism, Hyperprolactinemia, Hypothalamic tumor, Hypothyroidism, Laron Syndrome, Low Testosterone levels, Lymphomatous thyroiditis, Mauriac syndrome, Polycystic ovary Syndrome, Prediabetes, Pseudocyesis, Renal tubulopathy-diabetes mellitus-cerebellar ataxia, Riedel's thyroiditis, Sub clinical hypothyroidism, Maturity onset diabetes of the young, Nelson's syndrome, Morgagni syndrome, Hypogonadotrophic hypogonadism, Hypopituitarism, Wolfram syndrome, Adrenal incidentaloma, Pituitary tumour, Hypogonadism, Retinohepatoendocrinologic syndrome, Alstrom syndrome
Environmental	No underlying causes
Gastroenterologic	Budd-Chiari syndrome, Cirrhosis of the liver, Functioning pancreatic endocrine tumor, Hepatic veno-occlusive disease, Hepatic veno-occlusive disease-immunodeficiency, Insulinoma, Mauriac syndrome, Retinohepatoendocrinologic syndrome
Genetic	1p36 deletion syndrome, Carpenter's syndrome, Cohen Syndrome, Klinefelter syndrome, Macrosomia Obesity Macrocephaly Ocular abnormalities syndrome, Maturity onset diabetes of the young, X-linked mental retardation-short stature-obesity, X linked mental retardation-precocious puberty-obesity, Obesity due to congenital leptin deficiency, partial 9p duplication, Prader-Willi syndrome, Pseudohypoparathyroidism, Vasquez Hurst Sotos syndrome, Young Hughes syndrome, Albright's hereditary osteodystrophy, X-linked mental retardation-gynecomastia-obesity, Clark-Baraitser syndrome
Hematologic	Lipedema, Lymphatic obstruction, Milroy's syndrome, Paget-Schroeder syndrome
Iatrogenic	Excessive IV fluid, Nelson's syndrome, Orchidectomy, Ovarian hyperstimulation syndrome, Retinoic acid syndrome, Total parenteral nutrition
Infectious Disease	Elephantiasis, Infectobesity
Musculoskeletal / Ortho	Albright's hereditary osteodystrophy, Hyperostosis frontalis interna-obesity, Morgagni syndrome, Simpson-Golabi-Behmel syndrome, Summitt syndrome, Urban rogers meyer syndrome, Hypertrichosis brachydactyly obesity and mental retardation, Metaphyseal dysostosis mental retardation conductive deafness, Anophthalmia-short stature-obesity, Carpenter's syndrome, X-linked mental retardation-short stature-obesity, Prader-Willi syndrome, Vasquez Hurst Sotos syndrome, Borjeson Syndrome, Clark-Baraitser syndrome, Mental retardation-epilepsy-bulbous nose, Sengers-Hamel-Otten syndrome, Laurence-Moon-Biedl syndrome, Sohval-Soffer syndrome, Hydrocephalus obesity hypogonadism, Mental retardation-epileptic seizures-hypogonadism-hypogenitalism-microcephaly-obesity, Nguyen syndrome, Alstrom syndrome
Neurologic	Astrocytoma, Borjeson Syndrome, Borjeson-Forssman-Lehmann Syndrome, Chromophobe adenoma, Clark-Baraitser syndrome, Craniopharyngioma, Grahmann's syndrome, Hydrocephalus obesity hypogonadism, Hypogonadotrophic hypogonadism, Hypopituitarism, Mental retardation-blepharophimosis-obesity-web neck, Mental retardation-epilepsy-bulbous nose, Mental retardation-epileptic seizures-hypogonadism-hypogenitalism-microcephaly-obesity, Mental retardation-nasal hypoplasia-obesity-genital hypoplasia, X-linked mental retardation-gynecomastia-obesity, Nguyen syndrome, Sengers-Hamel-Otten syndrome, Sheehan's syndrome, Wilson-Turner X-linked mental retardation syndrome, Hyperpituitarism, 1p36 deletion syndrome, Young Hughes syndrome, Urban rogers meyer syndrome, Aniridia ptosis intellectual deficit familial obesity, Biemond syndrome type 2, Laurence-Moon-Biedl syndrome, Sohval-Soffer syndrome, Nelson's syndrome, Pituitary tumour, Hypertrichosis brachydactyly obesity and mental retardation, Metaphyseal dysostosis mental retardation conductive deafness, Prader-Willi syndrome, Vasquez Hurst Sotos syndrome, Hypothalamic tumor, Cohen Syndrome, Wilms tumor - aniridia - genitourinary anomalies - mental retardation, Renal tubulopathy-diabetes mellitus-cerebellar ataxia, Third ventricle tumor
Nutritional / Metabolic	Hyponatremia, Metabolic Syndrome, Overeating, Zinc
Obstetric/Gynecologic	Ovarian Cancer, Ovarian cyst, Preeclampsia, Pregnancy, Polycystic ovary Syndrome, Pseudocyesis, Sheehan's syndrome, Premenstrual dysphoric disorder, Premenstrual syndrome, Polycystic ovaries urethral sphincter dysfunction
Oncologic	Adrenal carcinoma, Adrenal incidentaloma, Pituitary tumour, Hypothalamic tumor, Functioning pancreatic endocrine tumor, Insulinoma, Astrocytoma, Chromophobe adenoma, Craniopharyngioma, Ovarian Cancer, Third ventricle tumor
Opthalmologic	Aniridia ptosis intellectual deficit familial obesity, Ayazi syndrome, Biemond syndrome type 2, Laurence-Moon-Biedl syndrome, Retinohepatoendocrinologic syndrome, Alstrom syndrome, Cohen Syndrome, Macrosomia Obesity Macrocephaly Ocular abnormalities syndrome, Mental retardation-blepharophimosis-obesity-web neck, Wilms tumor - aniridia - genitourinary anomalies - mental retardation, Wolfram syndrome, Anophthalmia-short stature-obesity, 1p36 deletion syndrome
Overdose / Toxicity	No underlying causes
Psychiatric	Atypical depression, Binge eating disorder, Bipolar disorder, Brief Psychotic Disorder, Compulsive eating, Depression, Disordered eating, Dysthymia, Night eating syndrome, Premenstrual dysphoric disorder, Premenstrual syndrome, Psychogenic dwarfism, Schizophrenia
Pulmonary	No underlying causes
Renal / Electrolyte	Nephrotic syndrome, Polycystic ovaries urethral sphincter dysfunction, Renal failure, Wilms tumor - aniridia - genitourinary anomalies - mental retardation, Beckwith-Wiedemann syndrome, Hypogonadism, Sohval-Soffer syndrome, Renal tubulopathy-diabetes mellitus-cerebellar ataxia, Beckwith-Wiedemann syndrome
Rheum / Immune / Allergy	Hepatic veno-occlusive disease-immunodeficiency
Sexual	Beckwith-Wiedemann syndrome, Hypogonadism, Sohval-Soffer syndrome, X linked mental retardation-precocious puberty-obesity, Borjeson-Forssman-Lehmann Syndrome, Hydrocephalus obesity hypogonadism, Mental retardation-epileptic seizures-hypogonadism-hypogenitalism-microcephaly-obesity, Mental retardation-nasal hypoplasia-obesity-genital hypoplasia, Nguyen syndrome, Polycystic ovaries urethral sphincter dysfunction, Castration, X-linked mental retardation-short stature-obesity, Borjeson Syndrome, Sengers-Hamel-Otten syndrome, Young Hughes syndrome, Urban rogers meyer syndrome, Biemond syndrome type 2, Polycystic ovary Syndrome, Vasquez Hurst Sotos syndrome, Wilms tumor - aniridia - genitourinary anomalies - mental retardation
Trauma	Hypothalamic trauma
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Aging, Alcohol-induced pseudo-Cushing syndrome, Bodybuilding, Bodybuilding, Castration, Doping, Emotional eating, Familial obesity, Force-feeding, Idiopathic edema, Immobility, Normal growing adolescent, Normal growing child, Normal growing infant, Oedema, Reaction to prior dieting, Sedentary lifestyle, Sleep deprivation, Sleep eating, Smoking cessation, Stress eating, Weight cycling, Wilson's temperature syndrome, Overeating, Night eating syndrome

Causes in Alphabetical Order

1p36 deletion syndrome 4-Chlorodehydromethyltestosterone Achard-Thiers Syndrome Acromegaly Adrenal carcinoma Adrenal incidentaloma Aging Albright's hereditary osteodystrophy Alcohol-induced pseudo-Cushing syndrome Aldesleukin Alstrom syndrome Amiodarone Amisulpride Amitriptyline Anastrozole Aniridia ptosis intellectual deficit familial obesity Anophthalmia-short stature-obesity Aripiprazole Asenapine Astrocytoma Atenolol Atypical depression Ayazi syndrome Azelastine Beckwith-Wiedemann syndrome Biemond syndrome type 2 Binge eating disorder Bipolar disorder Bisoprolol Bodybuilding Bodybuilding Borjeson Syndrome Borjeson-Forssman-Lehmann Syndrome Bosentan Brief Psychotic Disorder Budd-Chiari syndrome Carpenter's syndrome Carteolol Carvedilol Castration Chlorpropamide Chlorprothixene Chromophobe adenoma Ciprofloxacin Cirrhosis of the liver Clark-Baraitser syndrome Clomiphene Clomipramine Clozapine Cohen Syndrome Combined oral contraceptive pill Compulsive eating Craniopharyngioma Cushing's syndrome Cyclosporine Cyproheptadine Cyproterone Danazol Depression Desonide Desoximetasone Dexamethasone Diabetes mellitus Diclofenac Dienogest Diflunisal Disopyramide Disordered eating Docetaxel Doping Doxazosin Doxepin Doxorubicin Hydrochloride Dysthymia Elephantiasis Emotional eating Escitalopram Estrogen Injection Ethinylestradiol Etodolac Excessive IV fluid Familial obesity Fenoprofen Fentanyl Fludrocortisone acetate Force-feeding Froelich's syndrome Functioning pancreatic endocrine tumor Gabapentin Gestrinone Glatiramer Glucocorticoid Goserelin Grahmann's syndrome Growth hormone deficiency Growth Hormone Receptor Deficiency

HAIR-AN Syndrome Haloperidol Hashimoto's thyroiditis Heart failure Hepatic veno-occlusive disease Hepatic veno-occlusive disease-immunodeficiency Hormone replacement therapy Hydralazine Hydrocephalus obesity hypogonadism Hydrochlorothiazide Hydrocortisone Hyperostosis frontalis interna-obesity Hyperpituitarism Hyperprolactinemia Hypertrichosis brachydactyly obesity and mental retardation Hypogonadism Hypogonadotrophic hypogonadism Hyponatremia Hypopituitarism Hypothalamic trauma Hypothalamic tumor Hypothyroidism Idiopathic edema Iloperidone Imatinib Imipramine Immobility Implanon Indomethacin Infectobesity Insulin Insulinoma Interferon beta-1a Interferon beta-1b Itraconazole Ketorolac Ketotifen Klinefelter syndrome Labetalol Laron Syndrome Laurence-Moon-Biedl syndrome Levobunolol Levomepromazine Lipedema Lithium Lofepramine Low Testosterone levels Lymphatic obstruction Lymphomatous thyroiditis Macrosomia Obesity Macrocephaly Ocular abnormalities syndrome Maprotiline Maturity onset diabetes of the young Mauriac syndrome Meclofenamate Medroxyprogesterone Mefenamic acid Megestrol Meglitinide Mental retardation-blepharophimosis-obesity-web neck Mental retardation-epilepsy-bulbous nose Mental retardation-epileptic seizures-hypogonadism-hypogenitalism-microcephaly-obesity Mental retardation-nasal hypoplasia-obesity-genital hypoplasia Mesoridazine Metabolic Syndrome Metaphyseal dysostosis mental retardation conductive deafness Methylprednisolone Metoprolol Mianserin Milroy's syndrome Minoxidil Misoprostol Morgagni syndrome Nabumetone Nadolol Nelson's syndrome Nephrotic syndrome Nguyen syndrome Nialamide Night eating syndrome Normal growing adolescent Normal growing child Normal growing infant Norplant NuvaRing Obesity due to congenital leptin deficiency Oedema Olanzapine Oprelvekin Orchidectomy Ovarian Cancer Ovarian cyst Ovarian hyperstimulation syndrome Overeating Oxandrolone Oxcarbazepine

Oxymetholone Paget-Schroeder syndrome Paliperidone Paroxetine partial 9p duplication Perphenazine Phenelzine Phenothiazine Pindolol Pioglitazone Piroxicam Pituitary tumour Pizotifen Polycystic ovaries urethral sphincter dysfunction Polycystic ovary Syndrome Prader-Willi syndrome Prediabetes Prednisolone Preeclampsia Pregabalin Pregnancy Premenstrual dysphoric disorder Premenstrual syndrome Progesterone Propranolol Pseudocyesis Pseudohypoparathyroidism Psychogenic dwarfism Quetiapine Ractopamine Reaction to prior dieting Renal failure Renal tubulopathy-diabetes mellitus-cerebellar ataxia Reserpine Retinohepatoendocrinologic syndrome Retinoic acid syndrome Riedel's thyroiditis Risperidone Rituximab Rofecoxib Rosiglitazone Salsalate Sargramostim Schizophrenia Sedentary lifestyle Selective serotonin reuptake inhibitors Sengers-Hamel-Otten syndrome Sertindole Sertraline Sheehan's syndrome Simpson-Golabi-Behmel syndrome Sirolimus Sleep deprivation Sleep eating Smoking cessation Sohval-Soffer syndrome St John's wort Steroid medications Stress eating Sub clinical hypothyroidism Sulfonylureas Sulindac Summitt syndrome Sunitinib Temozolomide Terazosin Thiazolidinedione Thioridazine Thiothixene Third ventricle tumor Timolol Total parenteral nutrition Trazodone Trestolone Tretinoin Triamcinolone oral Tricyclic antidepressants Trifluoperazine Trifluperidol Urban rogers meyer syndrome Valproic acid Vasquez Hurst Sotos syndrome Venlafaxine Vigabatrin Weight cycling Wilms tumor - aniridia - genitourinary anomalies - mental retardation Wilson-Turner X-linked mental retardation syndrome Wilson's temperature syndrome Wolfram syndrome X linked mental retardation-precocious puberty-obesity X-linked mental retardation-gynecomastia-obesity X-linked mental retardation-short stature-obesity Young Hughes syndrome Zinc Ziprasidone Zotepine