Hydroquinone: Difference between revisions
Jump to navigation
Jump to search
Kiran Singh (talk | contribs) No edit summary |
Kiran Singh (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{DrugProjectFormSinglePage | {{DrugProjectFormSinglePage | ||
|genericName= | |authorTag={{KS}} | ||
|genericName=hydroquinone | |||
|aOrAn=a | |aOrAn=a | ||
|drugClass= | |drugClass=hyperpigmentation agent | ||
|indication= | |indicationType=treatment | ||
|indication=discoloration of skin, [[hyperpigmentation]] of skin | |||
|adverseReactions= | |adverseReactions=burning sensation, [[contact dermatitis]], localized [[erythema]] | ||
|blackBoxWarningTitle=Warning Title | |blackBoxWarningTitle=Warning Title | ||
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content) | |blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content) | ||
|fdaLIADAdult===== | |fdaLIADAdult===Indications== | ||
* Skin Lightening | |||
To gradually lighten [[hyperpigmentation]] of the skin such as age spots, liver spots, freckles or hyperpigmentation that can occur as a result of pregnancy or the use of oral contraceptives. | |||
* | ==Dosing== | ||
* Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases. | |||
|offLabelAdultGuideSupport===Indications and Dosage== | |||
* Discoloration of skin: emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months. | |||
: | * Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well. | ||
* Hyperpigmentation of skin: cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in. | |||
* | |||
: | |||
|offLabelPedGuideSupport===Indications and Dosage== | |||
* Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision. | |||
* Discoloration of skin: 12 years and older; emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months. | |||
* | * Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well. | ||
* Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in. | |||
|contraindications=* Hypersensitivity to hydroquinone or any component of hydroquinone products. | |||
* Pregnancy, safety not established. | |||
* Children 12 years of age and under; safety not established. | |||
|postmarketing=Dermatologic: Burning sensation, [[contact dermatitis]], localized [[erythema]] | |||
* | |||
|contraindications=* | |||
* | |||
* | |||
|postmarketing= | |||
|drugInteractions=* Drug 1 | |drugInteractions=* Drug 1 | ||
* Drug 2 | * Drug 2 | ||
| Line 208: | Line 74: | ||
|othersTitle=Others | |othersTitle=Others | ||
|useInOthers=(Description) | |useInOthers=(Description) | ||
|administration='''Topical''' | |||
* Avoid exposure of treated areas to sunlight. | |||
* Avoid contact with eyes. | |||
|monitoring=* Repigmentation | |||
|IVCompat= | |||
* Solution 1 | * Solution 1 | ||
| Line 350: | Line 130: | ||
* Solution 2 | * Solution 2 | ||
* Solution 3 | * Solution 3 | ||
|overdose | |overdose= | ||
|drugBox={{Drugbox2 | |drugBox={{Drugbox2 | ||
| verifiedrevid = | | verifiedrevid = | ||
| Line 422: | Line 188: | ||
| melting_point = | | melting_point = | ||
}} | }} | ||
|mechAction=( | |mechAction=* Hydroquinone inhibits the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppresses metabolic processes of melanocytes, thus producing depigmentation of the skin which is reversible | ||
|structure=(Description with picture) | |structure=(Description with picture) | ||
|PD=(Description) | |PD=(Description) | ||
| Line 439: | Line 205: | ||
(Description) | (Description) | ||
|howSupplied=(Description) | |howSupplied=(Description) | ||
|storage=* Store at room temperature (15-30°C / 59-86°F). | |||
* Close cap securely after each use. | |||
|fdaPatientInfo=(Patient Counseling Information) | |fdaPatientInfo=(Patient Counseling Information) | ||
| | |alcohol=Alcohol-Hydroquinone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication. | ||
|brandNames= ACTIVE 4 | |||
|lookAlike=* (Paired Confused Name 1a) — (Paired Confused Name 1b) | |lookAlike=* (Paired Confused Name 1a) — (Paired Confused Name 1b) | ||
* (Paired Confused Name 2a) — (Paired Confused Name 2b) | * (Paired Confused Name 2a) — (Paired Confused Name 2b) | ||
* (Paired Confused Name 3a) — (Paired Confused Name 3b) | * (Paired Confused Name 3a) — (Paired Confused Name 3b) | ||
|nlmPatientInfo=(Link to patient information page) | |||
|drugShortage=Drug Shortage | |drugShortage=Drug Shortage | ||
}} | }} | ||
Revision as of 17:22, 22 December 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]
Disclaimer
WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
Overview
Hydroquinone is a hyperpigmentation agent that is FDA approved for the treatment of discoloration of skin, hyperpigmentation of skin. Common adverse reactions include burning sensation, contact dermatitis, localized erythema.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Indications
- Skin Lightening
To gradually lighten hyperpigmentation of the skin such as age spots, liver spots, freckles or hyperpigmentation that can occur as a result of pregnancy or the use of oral contraceptives.
Dosing
- Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Indications and Dosage
- Discoloration of skin: emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.
- Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
- Hyperpigmentation of skin: cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Hydroquinone FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Indications and Dosage
- Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision.
- Discoloration of skin: 12 years and older; emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.
- Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
- Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
Contraindications
- Hypersensitivity to hydroquinone or any component of hydroquinone products.
- Pregnancy, safety not established.
- Children 12 years of age and under; safety not established.
Warnings
There is limited information regarding Hydroquinone Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Hydroquinone Clinical Trials Experience in the drug label.
Postmarketing Experience
Dermatologic: Burning sensation, contact dermatitis, localized erythema
Drug Interactions
- Drug 1
- Drug 2
- Drug 3
- Drug 4
- Drug 5
Drug 1
(Description)
Drug 2
(Description)
Drug 3
(Description)
Drug 4
(Description)
Drug 5
(Description)
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
(Description)
Pregnancy Category (AUS):
(Description)
Labor and Delivery
(Description)
Nursing Mothers
(Description)
Pediatric Use
(Description)
Geriatic Use
(Description)
Gender
(Description)
Race
(Description)
Renal Impairment
(Description)
Hepatic Impairment
(Description)
Females of Reproductive Potential and Males
(Description)
Immunocompromised Patients
(Description)
Others
(Description)
Administration and Monitoring
Administration
Topical
- Avoid exposure of treated areas to sunlight.
- Avoid contact with eyes.
Monitoring
- Repigmentation
IV Compatibility
- Solution 1
- Solution 2
- Solution 3
Not Tested
- Solution 1
- Solution 2
- Solution 3
Variable
- Solution 1
- Solution 2
- Solution 3
Incompatible
- Solution 1
- Solution 2
- Solution 3
TPN/TNA
Compatible
- Solution 1
- Solution 2
- Solution 3
Not Tested
- Solution 1
- Solution 2
- Solution 3
Variable
- Solution 1
- Solution 2
- Solution 3
Incompatible
- Solution 1
- Solution 2
- Solution 3
Overdosage
There is limited information regarding Hydroquinone overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
| |
Hydroquinone
| |
| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | ? |
| Chemical data | |
| Formula | ? |
| Mol. mass | ? |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Mechanism of Action
- Hydroquinone inhibits the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppresses metabolic processes of melanocytes, thus producing depigmentation of the skin which is reversible
Structure
(Description with picture)
Pharmacodynamics
(Description)
Pharmacokinetics
(Description)
Nonclinical Toxicology
(Description)
Clinical Studies
Condition 1
(Description)
Condition 2
(Description)
Condition 3
(Description)
How Supplied
(Description)
Storage
- Store at room temperature (15-30°C / 59-86°F).
- Close cap securely after each use.
Images
Drug Images
{{#ask: Page Name::Hydroquinone |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
{{#ask: Label Page::Hydroquinone |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
(Patient Counseling Information)
Precautions with Alcohol
Alcohol-Hydroquinone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
ACTIVE 4
Look-Alike Drug Names
- (Paired Confused Name 1a) — (Paired Confused Name 1b)
- (Paired Confused Name 2a) — (Paired Confused Name 2b)
- (Paired Confused Name 3a) — (Paired Confused Name 3b)
Drug Shortage Status
Drug Shortage
Price
References
The contents of this FDA label are provided by the National Library of Medicine.