Hydroquinone: Difference between revisions

Revision as of 17:51, 22 December 2014

{{DrugProjectFormSinglePage |authorTag=Kiran Singh, M.D. [1] |genericName=hydroquinone |aOrAn=a |drugClass=dermatological agent |indicationType=treatment |indication=discoloration of skin, hyperpigmentation of skin |adverseReactions=burning sensation, contact dermatitis, localized erythema |blackBoxWarningTitle=Warning Title |blackBoxWarningBody=Condition Name: (Content) |fdaLIADAdult===Indications==

Skin Lightening

To gradually lighten hyperpigmentation of the skin such as age spots, liver spots, freckles or hyperpigmentation that can occur as a result of pregnancy or the use of oral contraceptives.

Dosing

Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases.

|offLabelAdultGuideSupport===Indications and Dosage==

Discoloration of skin: emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.

Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.

Hyperpigmentation of skin: cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.

|offLabelAdultNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydroquinone in adult patients. |offLabelPedGuideSupport===Indications and Dosage==

Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision.

Discoloration of skin: 12 years and older; emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.

Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.

Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.

|offLabelPedNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydroquinone in pediatric patients. |contraindications=* Hypersensitivity to hydroquinone or any component of hydroquinone products.

Pregnancy, safety not established.
Children 12 years of age and under; safety not established.

|postmarketing=Dermatologic: Burning sensation, contact dermatitis, localized erythema |othersTitle=Others |administration=Topical

Avoid exposure of treated areas to sunlight.
Avoid contact with eyes.

|monitoring=* Repigmentation |drugBox=

Template:Chembox header2 \| Hydroquinone
Identifiers
CAS Number	123-31-9^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:17594^Y
ChEMBL	ChEMBL537^Y
ChemSpider	764^Y
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D00073^Y
UNII	XV74C1N1AE^Y
InChI InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H^Y Key: QIGBRXMKCJKVMJ-UHFFFAOYSA-N^Y InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H Key: QIGBRXMKCJKVMJ-UHFFFAOYAX
SMILES c1cc(ccc1O)O
Properties
Chemical formula	C₆H₆O₂
Molar mass	110.11 g·mol⁻¹
Template:Chembox header2 \| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

{{#subobject:

 |Label Page=Hydroquinone
 |Label Name=Hydroquinone ingredients and appearance.png

}}

{{#subobject:

 |Label Page=Hydroquinone
 |Label Name=Active 4.jpg

}}

@@ Line 3: / Line 3: @@
 |genericName=hydroquinone
 |aOrAn=a
-|drugClass=hyperpigmentation agent
+|drugClass=dermatological agent
 |indicationType=treatment
 |indication=discoloration of skin, [[hyperpigmentation]] of skin
@@ Line 40: / Line 40: @@
 * Avoid contact with eyes.
 |monitoring=* Repigmentation
+|drugBox={{chembox2
+| Watchedfields = changed
+| verifiedrevid = 443862076
+|  Name = Hydroquinone
+|   ImageFile_Ref = {{chemboximage|correct|??}}
+| ImageFile = Hydrochinon2.png
+|   ImageSize =
+|   ImageName = Hydroquinone
+|   ImageFile1 = Trans-hydroquinone-from-xtal-3D-balls.png
+|   ImageSize1 =
+|   ImageFile2 = Hydroquinone crystal.jpg
+|   IUPACName = Benzene-1,4-diol
+|   OtherNames = Idrochinone<br />Quinol/1-4 dihydroxy benzene/1-4 hydroxy benzene
+| Section1 = {{Chembox Identifiers
+|   ChEBI_Ref = {{ebicite|correct|EBI}}
+| ChEBI = 17594
+| SMILES = c1cc(ccc1O)O
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 764
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 537
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = XV74C1N1AE
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D00073
+| InChI = 1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
+| InChIKey = QIGBRXMKCJKVMJ-UHFFFAOYAX
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = QIGBRXMKCJKVMJ-UHFFFAOYSA-N
+| CASNo_Ref = {{cascite|correct|CAS}}
+| CASNo = 123-31-9
+| RTECS = MX3500000
+| ATCCode_prefix = D11
+| ATCCode_suffix = AX11
+  }}
+| Section2 = {{Chembox Properties
+|   C=6
+|   H=6
+|   O=2
+|   Appearance = white solid
+|   Density = 1.3 g cm<sup>−3</sup>, solid
+|   Solubility = 5.9 g/100 mL (15 °C)
+|   MeltingPtC = 172
+|   BoilingPtC = 287
+|   pKa =
+  }}
 |mechAction=* Hydroquinone inhibits the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppresses metabolic processes of melanocytes, thus producing depigmentation of the skin which is reversible
 |storage=* Store at room temperature (15-30°C / 59-86°F).

Hydroquinone: Difference between revisions

Revision as of 17:51, 22 December 2014

Dosing

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