Dimethyl sulfoxide: Difference between revisions

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{{DrugProjectFormSinglePage
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|aOrAn=a
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|indicationType=
|indication=
|hasBlackBoxWarning=Yes
|hasBlackBoxWarning=Yes
|adverseReactions=<!--Black Box Warning-->
|adverseReactions=<!--Black Box Warning-->
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<!--Use in Specific Populations-->
<!--Use in Specific Populations-->
|FDAPregCat=
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
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<!--Drug box 2-->
<!--Drug box 2-->
|drugBox=<!--Mechanism of Action-->
|drugBox={{Chembox new
|  Name = Dimethyl sulfoxide
|  ImageFile = DMSO-2D-dimensions.png
|  ImageSize = 120px
|  ImageName = Dimethyl sulfoxide
|  ImageFile1 = DMSO-3D-vdW.png
|  ImageSize1 = 100px
|  ImageName1 = 3D model of DMSO
|  ImageFile2 = DMSO-elpot.png
|  ImageSize2 = 100px
|  ImageName2 = 3D electric potential surface of DMSO
|  IUPACName = Dimethyl sulfoxide
|  OtherNames = Methyl sulfoxide<br />methylsulfinylmethane<br />DMSO
| Section1 = {{Chembox Identifiers
|  SMILES = CS(C)=O
|  CASNo = 67-68-5
|  RTECS = PV6210000
  }}
| Section2 = {{Chembox Properties
|  Formula = C<sub>2</sub>H<sub>6</sub>OS
|  MolarMass = 78.13 g/mol
|  Appearance = Clear, colorless liquid
|  Density = 1.1004 g/cm<sup>3</sup>, liquid
|  Solubility = Miscible
|  MeltingPt = 18.5 °C (292 K)
|  BoilingPt = 189 °C (462 K)
|  Viscosity = 1.996 [[Poise|cP]] at 20 °C
|  RefractIndex = 1.479<br /> [[Dielectric constant|ε<sub>r</sub>]] = 48
  }}
| Section3 = {{Chembox Structure
|  Dipole = 3.96 [[Debye|D]]
  }}
| Section7 = {{Chembox Hazards
|  ExternalMSDS = [http://ptcl.chem.ox.ac.uk/MSDS/ME/methyl_sulfoxide.html DMSO Material Safety Data Sheet]
|  MainHazards = Irritant (Xi)
|  NFPA-H = 1
|  NFPA-F = 1
|  NFPA-R =
|  RPhrases = {{R36/37/38}}
|  SPhrases = {{S26}}, {{S37/39}}
|  FlashPt = 95 °C
  }}
| Section8 = {{Chembox Related
|  Function = [[sulfoxide]]s
|  OtherFunctn = [[diethyl sulfoxide]]
|  OtherCpds = [[dimethyl sulfide]],<br /> [[methylsulfonylmethane|dimethyl sulfone]],<br /> [[acetone]]
  }}
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|mechAction=*  
|mechAction=*  


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|storage=
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|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.


Revision as of 19:15, 22 December 2014

Dimethyl sulfoxide
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Dimethyl sulfoxide is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Dimethyl sulfoxide in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimethyl sulfoxide in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Dimethyl sulfoxide in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Dimethyl sulfoxide in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimethyl sulfoxide in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Dimethyl sulfoxide in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Dimethyl sulfoxide in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Dimethyl sulfoxide in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Dimethyl sulfoxide during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Dimethyl sulfoxide with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Dimethyl sulfoxide with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Dimethyl sulfoxide with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Dimethyl sulfoxide with respect to specific gender populations.

Race

There is no FDA guidance on the use of Dimethyl sulfoxide with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Dimethyl sulfoxide in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Dimethyl sulfoxide in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Dimethyl sulfoxide in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Dimethyl sulfoxide in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Dimethyl sulfoxide in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Dimethyl sulfoxide in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Dimethyl sulfoxide in the drug label.

Pharmacology

Template:Chembox new

Mechanism of Action

Structure

File:Dimethyl sulfoxide01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Dimethyl sulfoxide in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Dimethyl sulfoxide in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Dimethyl sulfoxide in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Dimethyl sulfoxide in the drug label.

How Supplied

Storage

There is limited information regarding Dimethyl sulfoxide Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

{{#ask: Label Page::Dimethyl sulfoxide |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Dimethyl sulfoxide in the drug label.

Precautions with Alcohol

  • Alcohol-Dimethyl sulfoxide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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