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{{drugbox
{{DrugProjectFormSinglePage
| IUPAC_name = 3-(4-chlorophenyl)-''N'',''N''-dimethyl-<br>3-pyridin-2-yl-propan-1-amine
|authorTag=<!--Overview-->
| image =
|aOrAn=a
| width = 200px
|hasBlackBoxWarning=Yes
| CAS_number = 132-22-9
|adverseReactions=<!--Black Box Warning-->
| ATC_prefix = R06
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
| ATC_suffix = AB04
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
| PubChem = 2725
 
| DrugBank = APRD00001
* Content
| C = 16 |H = 19 |Cl = 1 |N = 2
 
| molecular_weight = 274.788 [[Gram|g]]/[[Mole (unit)|mol]]
<!--Adult Indications and Dosage-->
| bioavailability = 25 to 50%
 
| solubility = 0.55 g/100 mL, liquid
<!--FDA-Labeled Indications and Dosage (Adult)-->
| protein_bound = 72%
|fdaLIADAdult======Condition1=====
| metabolism = [[Liver|Hepatic]] ([[CYP2D6]])
 
| elimination_half-life = 21-27 [[hour]]s
* Dosing Information
| excretion = [[Kidney|Renal]]
 
| pregnancy_AU = A
:* Dosage
| pregnancy_US = B
 
| pregnancy_category =  
=====Condition2=====
| legal_AU = S3
 
| legal_UK = GSL
* Dosing Information
| legal_US = OTC
 
| legal_status = <br>(for oral forms)
:* Dosage
| routes_of_administration = Oral, [[Intravenous therapy|IV]], [[Intramuscular injection|IM]], [[Subcutaneous injection|SC]]
 
=====Condition3=====
 
* Dosing Information
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
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|offLabelAdultGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
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* Dosing Information
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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}}
'''Chlorphenamine''' ([[International Nonproprietary Name|INN]]) or '''chlorpheniramine''' ([[United States Approved Name|USAN]], former [[British Approved Name|BAN]]), commonly marketed as its salt '''chlorphenamine [[maleate]]''' (CPM; Chlor-Trimeton&reg;, Piriton&reg;, Chlor-Tripolon&reg;), is a first-generation [[antihistamine]] used in the prevention of the [[symptom]]s of [[allergy|allergic]] conditions such as [[rhinitis]] and [[urticaria]]. Its sedative effects are relatively weak compared to other first-generation antihistamines.
{{PillImage
|fileName=No image.jpg
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
<!--Pill Image-->
 
 
 
<!--Label Display Image-->


Chlorphenamine has [[antidepressant]] properties, [[reuptake inhibitor|inhibiting]] [[reuptake]] of the [[neurotransmitter]] [[serotonin]].  Based on this knowledge, the [[Sweden|Swedish]] company [[AstraZeneca|Astra AB]] was able to derive the first marketed [[selective serotonin reuptake inhibitor]], [[zimelidine]], from chlorphenamine.


==See also==
* [[Coricidin]]
* [[Chlorpheniramine and phenylpropanolamine]]
* [[Dexchlorpheniramine]]
[[Image:DSC000776.JPG|right|thumb|Chlorphenamine 4mg from U.K.]]


==References==
* Bruce G. Charlton, ''[http://www.hedweb.com/bgcharlton/sdtm.html Self-management of psychiatric symptoms using over-the-counter (OTC) psychopharmacology: the S-DTM therapeutic model - self-diagnosis, self-treatment, self-monitoring]''.  ''Medical Hypotheses'' [[2005]]; 65: 823-828.


{{antihistamines}}


[[Category:Antihistamines]]
<!--Category-->
[[Category:Selective serotonin reuptake inhibitors]]


[[es:Clorfenamina]]
[[Category:Drug]]
[[ja:クロルフェニラミン]]
[[zh:氯苯那敏]]
{{WikiDoc Help Menu}}

Revision as of 14:57, 9 January 2015

Chlorphenamine
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Chlorphenamine is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorphenamine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorphenamine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Chlorphenamine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorphenamine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorphenamine in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Chlorphenamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Chlorphenamine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorphenamine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Chlorphenamine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Chlorphenamine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Chlorphenamine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Chlorphenamine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Chlorphenamine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Chlorphenamine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Chlorphenamine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Chlorphenamine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Chlorphenamine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Chlorphenamine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Chlorphenamine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Chlorphenamine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Chlorphenamine in the drug label.

Pharmacology

There is limited information regarding Chlorphenamine Pharmacology in the drug label.

Mechanism of Action

Structure

File:Chlorphenamine01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Chlorphenamine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Chlorphenamine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Chlorphenamine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Chlorphenamine in the drug label.

How Supplied

Storage

There is limited information regarding Chlorphenamine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Chlorphenamine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Chlorphenamine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Chlorphenamine in the drug label.

Precautions with Alcohol

  • Alcohol-Chlorphenamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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