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{{WBRQuestion
{{WBRQuestion
|QuestionAuthor={{Rim}} {{Alison}}
|QuestionAuthor={{YD}} (Reviewed by {{YD}} and {{AJL}})
|ExamType=USMLE Step 1
|ExamType=USMLE Step 1
|MainCategory=Physiology
|MainCategory=Physiology
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|MainCategory=Physiology
|MainCategory=Physiology
|SubCategory=Genitourinary
|SubCategory=Genitourinary
|MainCategory=Physiology
|MainCategory=Physiology
|MainCategory=Physiology
|MainCategory=Physiology
|MainCategory=Physiology
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|MainCategory=Physiology
|MainCategory=Physiology
|SubCategory=Genitourinary
|SubCategory=Genitourinary
|Prompt=During development, testosterone secreted in-utero by the testes plays an important role in the differentiation of external and internal male organs by acting directly on the Wolffian ducts. Similarly, dihydrotestosterone (DHT), a more potent androgen produced from testosterone by the action of 5-alpha-reductase, is also involved in the differentiation of male organs. Which of the following processes is most likely achieved by the action of DHT?
|Prompt=During development, in-utero testosterone secretion by the testes act directly on the Wolffian ducts and play an important role in the differentiation of external and internal male organs. Similarly, dihydrotestosterone (DHT), a more potent androgen derived from testosterone by the action of 5-alpha-reductase, is also involved in the differentiation of male organs. Which of the following processes is a function of DHT?
|Explanation=In males, testosterone is involved in the differentiation of internal genitalia (excluding the prostate), voice deepening, and closure of the epiphyseal plates of bones. Growth spurt at puberty is also due to the action of testosterone, including the pubertal growth of the penis, seminal vesicles, and production of sperm. On the other hand, dihydrotestosterone is involved early in the differentiation of the external genitalia, i.e. the penis and the scrotum, and the prostate. Later, it is involved in the growth of the prostate, balding, and activity of sebaceous glands.
|Explanation=In males, testosterone is involved in the differentiation of internal genitalia (excluding the prostate), voice deepening, and closure of the epiphyseal plates of bones. The action of testosterone also includes the growth spurt at puberty, which includes the pubertal growth of the penis, seminal vesicles, and production of sperm. On the other hand, dihydrotestosterone (DHT) is involved early in the differentiation of the external genitalia, i.e. the penis, the scrotum, and the prostate. Later in life, DHT is involved in the growth of the prostate, balding, and the activity of sebaceous glands.
 
|EducationalObjectives= DHT is involved in the differentiation of the external genitalia, i.e. the penis and the scrotum, and the prostate.
|References= First Aid 2014 page 561
 
|AnswerA=Differentiation of the epididymis
|AnswerA=Differentiation of the epididymis
|AnswerAExp=Differentiation of the epididymis is achieved by the action of testosterone.
|AnswerAExp=Differentiation of the epididymis is a function of testosterone.
|AnswerB=Differentiation of the vas deferens
|AnswerB=Differentiation of the vas deferens
|AnswerBExp=Differentiation of the vas deferens is achieved by the action of testosterone.
|AnswerBExp=Differentiation of the vas deferens is achieved by the action of testosterone.
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|AnswerE=Pubertal voice deepening
|AnswerE=Pubertal voice deepening
|AnswerEExp=Pubertal voice deepening is achieved by the action of testosterone.
|AnswerEExp=Pubertal voice deepening is achieved by the action of testosterone.
|EducationalObjectives=DHT is involved in the differentiation of the external genitalia, i.e. the penis and the scrotum, and the prostate.
|References=First Aid 2014 page 561
|RightAnswer=D
|RightAnswer=D
|WBRKeyword=Differentiation, sex organs, testosterone, DHT, dihydrotestosterone, epididymis, vas deferens, genitals, genitalia, puberty, pubertal, penis, sperm, sebaceous, hormone, hormones
|WBRKeyword=Differentiation, sex organs, testosterone, DHT, dihydrotestosterone, epididymis, vas deferens, genitals, genitalia, puberty, pubertal, penis, sperm, sebaceous, hormone, hormones
|Approved=Yes
|Approved=Yes
}}
}}

Revision as of 19:15, 19 January 2015
Author [[PageAuthor::Yazan Daaboul, M.D. (Reviewed by Yazan Daaboul, M.D. and Alison Leibowitz [1])]]
Exam Type ExamType::USMLE Step 1
Main Category MainCategory::Physiology
Sub Category SubCategory::Genitourinary
Prompt [[Prompt::During development, in-utero testosterone secretion by the testes act directly on the Wolffian ducts and play an important role in the differentiation of external and internal male organs. Similarly, dihydrotestosterone (DHT), a more potent androgen derived from testosterone by the action of 5-alpha-reductase, is also involved in the differentiation of male organs. Which of the following processes is a function of DHT?]]
Answer A AnswerA::Differentiation of the epididymis
Answer A Explanation AnswerAExp::Differentiation of the epididymis is a function of testosterone.
Answer B AnswerB::Differentiation of the vas deferens
Answer B Explanation AnswerBExp::Differentiation of the vas deferens is achieved by the action of testosterone.
Answer C AnswerC::Closure of the epiphyseal plate
Answer C Explanation AnswerCExp::Closure of the epiphyseal plate is achieved by the action of testosterone.
Answer D AnswerD::Differentiation of the prostate gland
Answer D Explanation AnswerDExp::Differentiation of the prostate gland is achieved by the action of DHT.
Answer E AnswerE::Pubertal voice deepening
Answer E Explanation AnswerEExp::Pubertal voice deepening is achieved by the action of testosterone.
Right Answer RightAnswer::D
Explanation [[Explanation::In males, testosterone is involved in the differentiation of internal genitalia (excluding the prostate), voice deepening, and closure of the epiphyseal plates of bones. The action of testosterone also includes the growth spurt at puberty, which includes the pubertal growth of the penis, seminal vesicles, and production of sperm. On the other hand, dihydrotestosterone (DHT) is involved early in the differentiation of the external genitalia, i.e. the penis, the scrotum, and the prostate. Later in life, DHT is involved in the growth of the prostate, balding, and the activity of sebaceous glands.

Educational Objective: DHT is involved in the differentiation of the external genitalia, i.e. the penis and the scrotum, and the prostate.
References: First Aid 2014 page 561]]

Approved Approved::Yes
Keyword WBRKeyword::Differentiation, WBRKeyword::sex organs, WBRKeyword::testosterone, WBRKeyword::DHT, WBRKeyword::dihydrotestosterone, WBRKeyword::epididymis, WBRKeyword::vas deferens, WBRKeyword::genitals, WBRKeyword::genitalia, WBRKeyword::puberty, WBRKeyword::pubertal, WBRKeyword::penis, WBRKeyword::sperm, WBRKeyword::sebaceous, WBRKeyword::hormone, WBRKeyword::hormones
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