List of chemotherapeutic agents: Difference between revisions

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Revision as of 11:12, 3 February 2015

Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Overview

This is a list of chemotherapeutic agents (also known as cytotoxic agents) that are known to be of use in chemotherapy for cancer. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy). For example, the CHOP regimen consists of cyclophosphamide, hydroxydaunorubicin (doxorubicin), vincristine (Oncovin), and prednisone.

Besides chemotherapy, medical oncology (pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant articles.

Chemotherapeutic Agents by Category

Cytotoxic Chemotherapy

Alkylating agents

Anthracyclines

Antimetabolites

DNA synthesis inhibitors

Microtubule inhibitors

Nitrogen mustards

Nitrosureas

Platinum agents

Proteasome inhibitors

Taxanes

Topoisomerase inhibitors

Vinca alkaloids

Kinase inhibitors

HDAC inhibitors

Endocrine therapy

Antiandrogens

Steroid synthesis inhibitors

Androgen receptor inhibitors

5α-reductase inhibitors

GnRH agonists

GnRH antagonists

Aromatase inhibitors

Selective estrogen receptor modulators

Biologics

Antibody medications

Antibody-drug conjugates

Anti-HER2 medications

IL-6 inhibitors

Enzymes

Immunotherapy

Immunomodulatory drugs (IMiDs)

Hematopoietic Growth Factors

Erythrocyte growth factors

Granulocyte growth factors

Megakaryocyte growth factors

Supportive Medications

Chemotherapy protective agents

Antiemetic agents

RANK ligand inhibitors

Miscellaneous

Immunosuppresants

Radioimmunotherapy

Retinoids

Chemotherapeutic Agents in Alphabetical Order

@@ Line 11: / Line 11: @@
 Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles.
-== Alkylating agents ==
+==Chemotherapeutic Agents by Category==
-{{Main|Alkylating agent}}
+===Cytotoxic Chemotherapy===
-'''Bifunctional Alkylators'''
+===== Alkylating agents =====
-* [[Cyclophosphamide]]
+===== Anthracyclines =====
-* [[Mechlorethamine]]
+===== Antimetabolites =====
-* [[Chlorambucil]]
+===== DNA synthesis inhibitors =====
-* [[Melphalan]]
+===== Microtubule inhibitors =====
+===== Nitrogen mustards =====
-'''Monofunctional Alkylators'''
+===== Nitrosureas =====
-* [[Nitrosourea]]
+===== Platinum agents =====
-* [[Temozolomide]]
+===== Proteasome inhibitors =====
+===== Taxanes =====
-== Anthracyclines ==
+===== Topoisomerase inhibitors =====
-{{Main|anthracycline}}
+===== Vinca alkaloids =====
-* [[Daunorubicin]]
+----
-* [[Doxorubicin]]
+=== Kinase inhibitors ===
-* [[Epirubicin]]
+----
-* [[Idarubicin]]
+=== HDAC inhibitors ===
-* [[Mitoxantrone]]
+----
-* [[Valrubicin]]
+=== Endocrine therapy ===
+===== Antiandrogens =====
-== Cytoskeletal disruptors (Taxanes) ==
+===== Steroid synthesis inhibitors =====
-{{Main|Taxane}}
+===== Androgen receptor inhibitors =====
-* [[Paclitaxel]]
+===== 5α-reductase inhibitors =====
-* [[Docetaxel]]
+===== GnRH agonists =====
+===== GnRH antagonists =====
-== Epothilones ==
+===== Aromatase inhibitors =====
-{{Main|epothilone}}
+===== Selective estrogen receptor modulators =====
+----
-== Histone Deacetylase Inhibitors ==
+=== Biologics ===
-* [[Vorinostat]]
+===== Antibody medications =====
-* [[Romidepsin]]
+===== Antibody-drug conjugates =====
+===== Anti-HER2 medications =====
-== Inhibitors of Topoisomerase I ==
+===== IL-6 inhibitors =====
-{{Main|Topoisomerase inhibitor}}
+===== Enzymes =====
-* [[Irinotecan]]
+===== Immunotherapy =====
-* [[Topotecan]]
+===== Immunomodulatory drugs (IMiDs) =====
+* [[Lenalidomide|Lenalidomide (Revlimid)]]
-== Inhibitors of Topoisomerase II ==
+* [[Pomalidomide|Pomalidomide (Pomalyst)]]
-{{Main|Topoisomerase II inhibitor}}
+----
-* [[Etoposide]]
+=== Hematopoietic Growth Factors ===
-* [[Teniposide]]
+===== Erythrocyte growth factors =====
-* [[Tafluposide]]
+===== Granulocyte growth factors =====
+===== Megakaryocyte growth factors =====
-== Kinase inhibitors ==
+----
-{{Main|Kinase inhibitor}}
+=== Supportive Medications ===
-* [[Bortezomib]]
+===== Chemotherapy protective agents =====
-* [[Erlotinib]]
+===== Antiemetic agents =====
-* [[Gefitinib]]
+===== RANK ligand inhibitors =====
-* [[Imatinib]]
+----
-* [[Vemurafenib]]
+=== Miscellaneous ===
-* [[Vismodegib]]
+===== Immunosuppresants =====
+===== Radioimmunotherapy =====
-== Nucleotide analogs and precursor analogs ==
+===== Retinoids =====
-* [[Azacitidine]]
+----
-* [[Azathioprine]]
+== Chemotherapeutic Agents in Alphabetical Order ==
-* [[Capecitabine]]
-* [[Cytarabine]]
-* [[Doxifluridine]]
-* [[Fluorouracil]]
-* [[Gemcitabine]]
-* [[Hydroxyurea]]
-* [[Mercaptopurine]]
-* [[Methotrexate]]
-* [[Tioguanine]] (formerly Thioguanine)
-== Peptide antibiotics ==
-* [[Bleomycin]]
-* [[Actinomycin]]
-== Platinum-based agents ==
-{{Main|Platinum-based antineoplastic}}
-* [[Carboplatin]]
-* [[Cisplatin]]
-* [[Oxaliplatin]]
-== Retinoids ==
-* [[Tretinoin]]
-* [[Alitretinoin]]
-* [[Bexarotene]]
-== Vinca alkaloids and derivatives ==
-{{Main|Vinca alkaloid}}
-* [[Vinblastine]]
-* [[Vincristine]]
-* [[Vindesine]]
-* [[Vinorelbine]]
-==Chemotherapeutic Agents in Alphabetical Order==
 * [[Abiraterone|Abiraterone acetate (Zytiga)]]
 * [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]