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Created page with "<!-- == Risk Factors == ==== NCCN Infection Risk Categories ==== The National Comprehensive Cancer Network (NCCN) Guidelines provide a set of categories (low, intermediate, a..."
 
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== Risk Factors ==


==== NCCN Infection Risk Categories ====
The National Comprehensive Cancer Network (NCCN) Guidelines provide a set of categories (low, intermediate, and high risk for infection) in patients with cancer based on factors such as the underlying malignancy, disease status (eg, active disease, disease in remission), duration of neutropenia, prior exposure to chemotherapy, and intensity of immunosuppressive therapies.


Patients with solid tumors receiving standard chemotherapy regimens and who have an anticipated duration of neutropenia shorter than 7 days are considered at '''low risk''' for infectious complications; thus, antimicrobial prophylaxis is not routinely recommended in these patients.  For patients with HSV-positive serology who are otherwise at low risk for infections, prophylaxis with antivirals amy be considered.  '''Intermediate risk''' refer to patients with an anticipated duration of neutropenia of 7 to 10 days. Patients with lymphoma, multiple myeloma, or CLL; autologous HSCT recipients; or patients receiving treatment with purine analog-containing regimens (most often for hematologic malignancies such as NHL or CLL) are also considered intermediate risk.
== Prophylaxis ==


=== Antibacterial prophylaxis ===
=== Antifungal prophylaxis ===
=== Antiviral prophylaxis ===


== Treatment ==


* Pre-emptive therapy
=== Prophylaxis for ''Pneumocystis jirovecii'' ===
:: Antibacterial prophylaxis
:: Antifungal prophylaxis
:: Antiviral prophylaxis
:: Prophylaxis for Pneumocystis jirovecii
* Empiric therapy
:: Treatment options for high-risk patients
:: Treatment options for high-risk patients
* Site-specific therapy
::


=== Pre-emptive therapy ===






== Treatment ==


=== Empiric therapy ===
=== Empiric therapy ===
==== Treatment options for high-risk patients ====
==== Treatment options for high-risk patients ====
* Intravenous antibiotic monotherapy in hospital (for uncomplicated cases)
* Intravenous antibiotic monotherapy in hospital (for uncomplicated cases)
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:* Ciprofloxacin 500 mg every 8 h + clindamycin 600 mg every 8 h (for penicillin-allergic patients)
:* Ciprofloxacin 500 mg every 8 h + clindamycin 600 mg every 8 h (for penicillin-allergic patients)
:: <sup>†</sup> Criteria for oral antibiotics: no nausea or vomiting, patient able to tolerate oral medications, and patient not on prior fluoroquinolone prophylaxis.
:: <sup>†</sup> Criteria for oral antibiotics: no nausea or vomiting, patient able to tolerate oral medications, and patient not on prior fluoroquinolone prophylaxis.


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Revision as of 12:32, 13 February 2015