Natural killer cell deficiency: Difference between revisions
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{{SK}} Classical NK cell deficiency, CNKD, functional NK cell deficiency, FNKD, NK cells deficiency syndrome, NK cell immunosuppression, Isolated NK cell deficiency | {{SK}} Classical NK cell deficiency, CNKD, CKND subtype 1, CNKD1, CKND subtype 12, CNKD2, functional NK cell deficiency, FNKD, FKND subtype 1, FKND1, NKD, NK cells deficiency syndrome, NK cell immunosuppression, Isolated NK cell deficiency | ||
==Overview== | ==Overview== | ||
Natural kill (NK) cells deficiency is a rare condition characterized by either the deficiency, absence, or malfunction of NK | Natural kill (NK) cells deficiency is a rare condition characterized by either the deficiency, absence, or malfunction of [[NK cell]]s, without the involvement of other types of immunological abnormalities and in the absence of secondary etiologies such as medications or viral infections.<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> | ||
==Classification== | ==Classification== | ||
* Classical NK cell deficiency (CNKD) | * Classical NK cell deficiency (CNKD): Absence of [[NK cell]]s in the peripheral blood | ||
* Functional NK cell deficiency (FNKD) | ** CKND subtype 1 | ||
** CKND subtype 2 | |||
* Functional NK cell deficiency (FNKD): Presence of [[NK cell]]s in the peripheral blood but with abnormal function | |||
**FKND subtype 1<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> | |||
==Causes== | |||
===Genes=== | |||
* GATA2 (CNKD1) | |||
* MCM4 (CNKD2) | |||
* FCGR3A (FNKD1)<ref name="pmid23993353">{{cite journal| author=Orange JS| title=Natural killer cell deficiency. | journal=J Allergy Clin Immunol | year= 2013 | volume= 132 | issue= 3 | pages= 515-25; quiz 526 | pmid=23993353 | doi=10.1016/j.jaci.2013.07.020 | pmc=PMC3917661 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23993353 }} </ref> | |||
==References== | ==References== | ||
Revision as of 21:56, 16 February 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Classical NK cell deficiency, CNKD, CKND subtype 1, CNKD1, CKND subtype 12, CNKD2, functional NK cell deficiency, FNKD, FKND subtype 1, FKND1, NKD, NK cells deficiency syndrome, NK cell immunosuppression, Isolated NK cell deficiency
Overview
Natural kill (NK) cells deficiency is a rare condition characterized by either the deficiency, absence, or malfunction of NK cells, without the involvement of other types of immunological abnormalities and in the absence of secondary etiologies such as medications or viral infections.[1]
Classification
- Classical NK cell deficiency (CNKD): Absence of NK cells in the peripheral blood
- CKND subtype 1
- CKND subtype 2
- Functional NK cell deficiency (FNKD): Presence of NK cells in the peripheral blood but with abnormal function
- FKND subtype 1[1]
Causes
Genes
- GATA2 (CNKD1)
- MCM4 (CNKD2)
- FCGR3A (FNKD1)[1]
References
- ↑ 1.0 1.1 1.2 Orange JS (2013). "Natural killer cell deficiency". J Allergy Clin Immunol. 132 (3): 515–25, quiz 526. doi:10.1016/j.jaci.2013.07.020. PMC 3917661. PMID 23993353.