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| {{Pancytopenia}}
| | #Redirect [[Pancytopenia]] |
| {{CMG}}'''; Associate Editor-In-Chief:''' {{CZ}}
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| ==Overview==
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| '''Pancytopenia''' is the pronounced reduction in the number of [[erythrocyte]]s, all types of [[white blood cell]]s and blood [[platelets]] that are circulating in the blood.
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| [[Pancytopenia]] is generally due to diseases affecting the [[bone marrow]], although peripheral destruction of all lines of blood cells in [[hypersplenism]] (overactive [[spleen]]) is a recognized cause. [[Bone marrow]] problems causing [[pancytopenia]] include [[myelofibrosis]], [[leukemia]], [[aplastic anemia]], and the malignant form of [[osteoporosis]].
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| Chemotherapy for malignancies may also cause [[pancytopenia]], if the drug or drugs used cause [[bone marrow]] suppression.
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| Increasingly, [[HIV]] ([[Human Immunodeficiency Virus]]) is itself a cause for [[pancytopenia]].
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| Rarely, drugs (antibiotics, anti hypertensive medication, heart medication) can cause [[pancytopenia]].
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| [[Pancytopenia]] usually requires a [[bone marrow]] [[biopsy]] in order to distinguish among different causes. | |
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| In alphabetical order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
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| ==Differential diagnosis==
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| ===Congenital===
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| *[[Cartilage hair hypoplasia]]
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| *[[Diamond-Blackfan syndrome]]
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| *[[Dubowitz syndrome]]
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| *[[Dyskeratosis congenita]]
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| *[[Familial aplastic anemia]]
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| *[[Fanconi's anemia]]
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| *[[Pearson syndrome]]
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| *[[Schwachman-Diamond syndrome]]
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| *[[TAR syndrome]]
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| ===Acquired===
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| *[[Albers-Schonberg disease]]
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| *[[Banti's Syndrome]]
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| *[[Bone marrow]] [[tumor]]
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| *[[Cirrhosis]]
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| *[[Drug]]s/[[Toxins]]
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| *[[Felty's Syndrome]]
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| *[[Gaucher's Disease]]
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| *[[Graft-versus-host disease]]
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| *[[Infection]]s
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| *[[Kala-Azar]]
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| *[[Leukemia]]
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| *[[Lymphoma]]
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| *[[Lymphoproliferative Disorders]]
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| *[[Myelodysplastic syndrome]]
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| *[[Myelofibrosis]]
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| *[[Niemann-Pick Disease]]
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| *[[Osteoporosis]]
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| *[[Pernicious anemia]]
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| *[[Reticulosis]]
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| *[[Sarcoidosis]]
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| *[[Thymoma]]
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| *[[Tuberculosis]]
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| ==References==
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| {{Reflist|2}}
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| [[Category:Blood tests]]
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| [[Category:Hematology]]
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| [[Category:Oncology]]
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| [[Category:Oncology stub]]
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