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<div style="-webkit-user-select: none;">


== Prophylaxis ==
===Part 1===


=== Antibacterial prophylaxis ===
{| style="width: 100%;"
| style="width: 10%;" valign=top |


<font color="#FF0000">'''''Click on boxes to expand/collapse detailed information.'''''</font>


=== Antifungal prophylaxis ===


{{Family tree/start}}
{{Family tree|border=0| | | | | | | | | | | B01 | | | | | | | | | | |B01=
<div class="mw-customtoggle-box01" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 01}}
</div>
}}
{{Family tree|border=0| | | | | | | | | | | |!| | | | | | | | | | | |}}
{{Family tree|border=0| | | | | | | | | B02 | | | | | | | | | | |B02=
<div class="mw-customtoggle-box02" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 240%;">
{{fontcolor|#F8F8FF|Box 02}}
</div>
}}
{{Family tree|border=0| | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | |}}
{{Family tree|border=0| | | | | B03 | | | | | | | | | B04 | | | | |B03=
<div class="mw-customtoggle-box03" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 03}}
</div>
|B04=
<div class="mw-customtoggle-box04" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 160%;">
{{fontcolor|#F8F8FF|Box 04}}
</div>
}}
{{Family tree|border=0| | | |,|-|^|-|.| | | | | |,|-|-|-|+|-|-|.| |}}
{{Family tree|border=0| | | B05 | | B06 | | | B07 | | | B08 | B09 |B05=
<div class="mw-customtoggle-box05" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 05}}
</div>
|B06=
<div class="mw-customtoggle-box06" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 06}}
</div>
|B07=
<div class="mw-customtoggle-box07" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 160%;">
{{fontcolor|#F8F8FF|Box 07}}
</div>
|B08=
<div class="mw-customtoggle-box08" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 08}}
</div>
|B09=
<div style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #545454; width: 80%;">
[[Sandbox algorithm#Part 2|{{fontcolor|#F8F8FF|Part 2}}]]
</div>
}}
{{Family tree/end}}
</div>


=== Antiviral prophylaxis ===
| style="width: 950px; valign=top |


<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box01" style="background: #F5F5F5; padding: 5px 10px;">


=== Prophylaxis for ''Pneumocystis jirovecii'' ===
==Box 01==


❑ Item 1


❑ Item 2


❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box02" style="background: #F5F5F5; padding: 5px 10px;">
==Box 02==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box03" style="background: #F5F5F5; padding: 5px 10px;">
==Box 03==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box04" style="background: #F5F5F5; padding: 5px 10px;">
==Box 04==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box05" style="background: #F5F5F5; padding: 5px 10px;">
==Box 05==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box06" style="background: #F5F5F5; padding: 5px 10px;">
==Box 06==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box07" style="background: #F5F5F5; padding: 5px 10px;">
==Box 07==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box08" style="background: #F5F5F5; padding: 5px 10px;">
==Box 08==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
|}
<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR>
----
===Part 2===
{| style="width: 100%;"
| style="width: 10%;" valign=top |
<font color="#FF0000">'''''Click on boxes to expand/collapse detailed information.'''''</font>
{{Family tree/start}}
{{Family tree|border=0| | | | | | | | | | | B11 | | | | | | | | | | |B11=
<div class="mw-customtoggle-box11" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 11}}
</div>
}}
{{Family tree|border=0| | | | | | | | | | | |!| | | | | | | | | | | |}}
{{Family tree|border=0| | | | | | | | | B12 | | | | | | | | | | |B12=
<div class="mw-customtoggle-box12" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 240%;">
{{fontcolor|#F8F8FF|Box 12}}
</div>
}}
{{Family tree|border=0| | | | | |,|-|-|-|-|-|^|-|-|-|-|-|.| | | | | |}}
{{Family tree|border=0| | | | | B13 | | | | | | | | | B14 | | | | |B13=
<div class="mw-customtoggle-box13" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 13}}
</div>
|B14=
<div class="mw-customtoggle-box14" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 160%;">
{{fontcolor|#F8F8FF|Box 14}}
</div>
}}
{{Family tree|border=0| | | |,|-|^|-|.| | | | | |,|-|-|-|+|-|-|.| |}}
{{Family tree|border=0| | | B15 | | B16 | | | B17 | | | B18 | B19 |B15=
<div class="mw-customtoggle-box15" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 15}}
</div>
|B16=
<div class="mw-customtoggle-box16" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 16}}
</div>
|B17=
<div class="mw-customtoggle-box17" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 160%;">
{{fontcolor|#F8F8FF|Box 17}}
</div>
|B18=
<div class="mw-customtoggle-box18" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 18}}
</div>
|B19=
<div class="mw-customtoggle-box19" style="cursor: pointer; border-radius: 5px 5px 5px 5px; text-align: center; border: solid 1px #696969; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5); box-shadow: inset 0 1px 1px rgba(255, 255, 255, 0.5), 0 1px 1px rgba(0, 0, 0, 0.5); background: #A8A8A8; width: 80%;">
{{fontcolor|#F8F8FF|Box 19}}
</div>
}}
{{Family tree/end}}
| style="width: 90%; valign=top |
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box11" style="background: #F5F5F5; padding: 5px 10px;">
==Box 11==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box12" style="background: #F5F5F5; padding: 5px 10px;">
==Box 12==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box13" style="background: #F5F5F5; padding: 5px 10px;">
==Box 13==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box14" style="background: #F5F5F5; padding: 5px 10px;">
==Box 14==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box15" style="background: #F5F5F5; padding: 5px 10px;">
==Box 15==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box16" style="background: #F5F5F5; padding: 5px 10px;">
==Box 16==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box17" style="background: #F5F5F5; padding: 5px 10px;">
==Box 17==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box18" style="background: #F5F5F5; padding: 5px 10px;">
==Box 18==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
<div class="mw-collapsible mw-collapsed" id="mw-customcollapsible-box19" style="background: #F5F5F5; padding: 5px 10px;">
==Box 19==
❑ Item 1
❑ Item 2
❑ Item 3
</div>
|}
<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR>
==References==
{{reflist|2}}
==See Also==
* [http://www.wikidoc.org/index.php?title=Sandbox_algorithm&mobileaction=toggle_view_desktop Sandbox algorithm (desktop/tablet version)]
* [http://www.wikidoc.org/index.php?title=Sandbox_algorithm_mobile&mobileaction=toggle_view_desktop Sandbox algorithm (mobile version)]
<--


== Treatment ==
== Treatment ==
Line 38: Line 370:
:* Ciprofloxacin 500 mg every 8 h + clindamycin 600 mg every 8 h (for penicillin-allergic patients)
:* Ciprofloxacin 500 mg every 8 h + clindamycin 600 mg every 8 h (for penicillin-allergic patients)
:: <sup>†</sup> Criteria for oral antibiotics: no nausea or vomiting, patient able to tolerate oral medications, and patient not on prior fluoroquinolone prophylaxis.
:: <sup>†</sup> Criteria for oral antibiotics: no nausea or vomiting, patient able to tolerate oral medications, and patient not on prior fluoroquinolone prophylaxis.


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Revision as of 18:20, 17 February 2015


Part 1

Click on boxes to expand/collapse detailed information.


 
 
 
 
 
 
 
 
 
 

Box 01

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 02

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 03

 
 
 
 
 
 
 
 

Box 04

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 05

 

Box 06

 
 

Box 07

 
 

Box 08

Box 01

❑ Item 1

❑ Item 2

❑ Item 3

Box 02

❑ Item 1

❑ Item 2

❑ Item 3

Box 03

❑ Item 1

❑ Item 2

❑ Item 3

Box 04

❑ Item 1

❑ Item 2

❑ Item 3

Box 05

❑ Item 1

❑ Item 2

❑ Item 3

Box 06

❑ Item 1

❑ Item 2

❑ Item 3

Box 07

❑ Item 1

❑ Item 2

❑ Item 3

Box 08

❑ Item 1

❑ Item 2

❑ Item 3














Part 2

Click on boxes to expand/collapse detailed information.


 
 
 
 
 
 
 
 
 
 

Box 11

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 12

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 13

 
 
 
 
 
 
 
 

Box 14

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Box 15

 

Box 16

 
 

Box 17

 
 

Box 18

Box 19

Box 11

❑ Item 1

❑ Item 2

❑ Item 3

Box 12

❑ Item 1

❑ Item 2

❑ Item 3

Box 13

❑ Item 1

❑ Item 2

❑ Item 3

Box 14

❑ Item 1

❑ Item 2

❑ Item 3

Box 15

❑ Item 1

❑ Item 2

❑ Item 3

Box 16

❑ Item 1

❑ Item 2

❑ Item 3

Box 17

❑ Item 1

❑ Item 2

❑ Item 3

Box 18

❑ Item 1

❑ Item 2

❑ Item 3

Box 19

❑ Item 1

❑ Item 2

❑ Item 3













References

See Also





<--

Treatment

Empiric therapy

Treatment options for high-risk patients

  • Intravenous antibiotic monotherapy in hospital (for uncomplicated cases)
  • Imipenem/cilastatin 500 mg IV every 6 h
  • Meropenem 1 gram IV every 8 h
  • Piperacillin/tazobactam 4.5 grams IV every 6 h
  • Cefepime 2 grams IV every 8 h
  • Ceftazidime 2 grams IV every 8 h

Treatment options for low-risk patients

  • Intravenous antibiotics at home
  • Daily long-acting intravenous agent ± oral therapy at home or office
  • Oral antibiotic combination therapy
  • Ciprofloxacin + amoxicillin/clavulanate both at 500 mg every 8 h
  • Moxifloxacin 400 mg every 24 h
  • Ciprofloxacin 500 mg every 8 h + clindamycin 600 mg every 8 h (for penicillin-allergic patients)
Criteria for oral antibiotics: no nausea or vomiting, patient able to tolerate oral medications, and patient not on prior fluoroquinolone prophylaxis.

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