Anaplastic large cell lymphoma, ALK negative: Difference between revisions
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==Overview== | ==Overview== | ||
The ALK negative anaplastic large cell lymphoma is a [[peripheral T-cell lymphoma]] [[Non-Hodgkin's lymphoma]]. ALK negative ALCL [[T-cell]]s express [[CD30]], but doesn't express the ALK ('''A'''naplastic '''L'''ymphoma '''K'''inase) chimeric protein | The ALK negative anaplastic large cell lymphoma is a [[peripheral T-cell lymphoma]] [[Non-Hodgkin's lymphoma]]. ALK negative ALCL [[T-cell]]s express [[CD30]], but doesn't express the ALK ('''A'''naplastic '''L'''ymphoma '''K'''inase) chimeric protein,<ref name=Swerdlow>{{cite book | last = Swerdlow | first = Steven | title = WHO classification of tumours of haematopoietic and lymphoid tissues | publisher = International Agency for Research on Cancer | location = Lyon, France | year = 2008 | isbn = 9789283224310 }}</ref> reason why the clinical outcome is more variable than the [[ALK(+)-ALCL]].<ref name="pmid25461779">{{cite journal| author=Xing X, Feldman AL| title=Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous. | journal=Adv Anat Pathol | year= 2015 | volume= 22 | issue= 1 | pages= 29-49 | pmid=25461779 | doi=10.1097/PAP.0000000000000047 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25461779 }} </ref> | ||
==Classification== | ==Classification== | ||
Revision as of 20:54, 20 February 2015
Template:DiseaseDisorder infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
Synonyms and keywords: ALCL-ALK(-); ALK-negative ALCL; ALK negative ALCL; ALK negative anaplastic large cell lymphoma
Overview
The ALK negative anaplastic large cell lymphoma is a peripheral T-cell lymphoma Non-Hodgkin's lymphoma. ALK negative ALCL T-cells express CD30, but doesn't express the ALK (Anaplastic Lymphoma Kinase) chimeric protein,[1] reason why the clinical outcome is more variable than the ALK(+)-ALCL.[2]
Classification
Morphologic Classification
Pathophysiology
Causes
Differential Diagnosis
Epidemiology and Demographics
Natural History, Complications and Prognosis
Prognosis
Diagnosis
History and Symptoms
Laboratory Findings
Treatment
References
- ↑ Swerdlow, Steven (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. ISBN 9789283224310.
- ↑ Xing X, Feldman AL (2015). "Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous". Adv Anat Pathol. 22 (1): 29–49. doi:10.1097/PAP.0000000000000047. PMID 25461779.