GRADE system classification scheme: Difference between revisions

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==Overview==
==Overview==
The Grading of Recommendations Assessment, Development and Evaluation (GRADE ) is a system developed by a widely representative group of international guideline developers for rating quality of evidence and strength of recommendations that is explicit, comprehensive, transparent, and pragmatic. It is increasingly being adopted by organisation's worldwide for systematic reviews and health technology assessments, as well as guidelines.
Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to guide assessment of '''quality of evidence''' from high (A) to very low (D) and to determine the '''strength of recommendations''' as strong (1) or weak (2).


==Levels of Evidence<ref name="Guyatt-2008">{{Cite journal  | last1 = Guyatt | first1 = GH. | last2 = Oxman | first2 = AD. | last3 = Vist | first3 = GE. | last4 = Kunz | first4 = R. | last5 = Falck-Ytter | first5 = Y. | last6 = Alonso-Coello | first6 = P. | last7 = Schünemann | first7 = HJ. | last8 = Alderson | first8 = P. | last9 = Alonso-Coello | first9 = P. | title = GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | journal = BMJ | volume = 336 | issue = 7650 | pages = 924-6 | month = Apr | year = 2008 | doi = 10.1136/bmj.39489.470347.AD | PMID = 18436948 }}</ref>==
==Levels of Evidence<ref name="Guyatt-2008">{{Cite journal  | last1 = Guyatt | first1 = GH. | last2 = Oxman | first2 = AD. | last3 = Vist | first3 = GE. | last4 = Kunz | first4 = R. | last5 = Falck-Ytter | first5 = Y. | last6 = Alonso-Coello | first6 = P. | last7 = Schünemann | first7 = HJ. | last8 = Alderson | first8 = P. | last9 = Alonso-Coello | first9 = P. | title = GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | journal = BMJ | volume = 336 | issue = 7650 | pages = 924-6 | month = Apr | year = 2008 | doi = 10.1136/bmj.39489.470347.AD | PMID = 18436948 }}</ref>==

Revision as of 17:23, 3 March 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to guide assessment of quality of evidence from high (A) to very low (D) and to determine the strength of recommendations as strong (1) or weak (2).

Levels of Evidence[1]

Quality of evidence Definition
High quality (Grade A) Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality (Grade B) Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality (Grade C) Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality (Grade D) Any estimate of effect is very uncertain.

References

  1. Guyatt, GH.; Oxman, AD.; Vist, GE.; Kunz, R.; Falck-Ytter, Y.; Alonso-Coello, P.; Schünemann, HJ.; Alderson, P.; Alonso-Coello, P. (2008). "GRADE: an emerging consensus on rating quality of evidence and strength of recommendations". BMJ. 336 (7650): 924–6. doi:10.1136/bmj.39489.470347.AD. PMID 18436948. Unknown parameter |month= ignored (help)