GRADE system classification scheme: Difference between revisions
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==Overview== | ==Overview== | ||
Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to | Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to determine the '''strength of recommendations''' as strong (1) or weak (2) and to guide assessment of '''quality of evidence''' from high (A) to very low (D). | ||
== | ==Strength of Recommendations== | ||
The GRADE system classifies recommendations as '''strong (grade 1)''' or '''weak (grade 2)'''. Factors influencing this determination are as follows: | |||
{| | {| style="margin: 5px 10px;" | ||
! | ! style="font-size: 85%; background: #545454; color: #F8F8FF; padding: 5px 10px;" | What Should be Considered | ||
! style="font-size: 85%; background: #545454; color: #F8F8FF; padding: 5px 10px;" | Recommended Process | |||
|- | |- | ||
| High quality | | style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | High or moderate evidence (Is there high or moderate quality evidence?) | ||
| style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | The higher the quality of evidence, the more likely a strong recommendation. | |||
|- | |- | ||
| | | style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | Certainty about the balance of benefits vs. harms and burdens (Is there certainty?) | ||
| style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | The larger the difference between the desirable and undesirable consequences and the certainty around that difference, the more likely a strong recommendation. The smaller the net benefit and the lower the certainty for that benefit, the more likely a weak recommendation. | |||
|- | |- | ||
| | | style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | Certainty in or similar values (Is there certainty or similarity?) | ||
| style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | The more certainty or similarity in values and preferences, the more likely a strong recommendation. | |||
|- | |- | ||
| | | style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | Resource implications (Are resources worth expected benefits?) | ||
| style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | The lower the cost of an intervention compared to the alternative and other costs related to the decision–ie, fewer resources consumed–the more likely a strong recommendation. | |||
|} | |} | ||
==Quality of Evidence== | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:44, 3 March 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was developed to determine the strength of recommendations as strong (1) or weak (2) and to guide assessment of quality of evidence from high (A) to very low (D).
Strength of Recommendations
The GRADE system classifies recommendations as strong (grade 1) or weak (grade 2). Factors influencing this determination are as follows:
| What Should be Considered | Recommended Process |
|---|---|
| High or moderate evidence (Is there high or moderate quality evidence?) | The higher the quality of evidence, the more likely a strong recommendation. |
| Certainty about the balance of benefits vs. harms and burdens (Is there certainty?) | The larger the difference between the desirable and undesirable consequences and the certainty around that difference, the more likely a strong recommendation. The smaller the net benefit and the lower the certainty for that benefit, the more likely a weak recommendation. |
| Certainty in or similar values (Is there certainty or similarity?) | The more certainty or similarity in values and preferences, the more likely a strong recommendation. |
| Resource implications (Are resources worth expected benefits?) | The lower the cost of an intervention compared to the alternative and other costs related to the decision–ie, fewer resources consumed–the more likely a strong recommendation. |