Rhabdomyolysis causes: Difference between revisions
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| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| [[Acetaminophen and Oxycodone]], [[Cytarabine]], [[Diphenhydramine]], [[Entacapone]], [[Felbamate]], [[Iodixanol]], [[Isotretinoin]], [[lamivudine]], [[Sorafenib]], [[Sulfasalazine]] | |bgcolor="Beige"| [[Acetaminophen and Oxycodone]], [[Cytarabine]], [[Diphenhydramine]], [[Entacapone]], [[Felbamate]], [[Iodixanol]], [[Isotretinoin]], [[lamivudine]], [[Sorafenib]], [[Sulfasalazine]], [[Trospium]] | ||
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Revision as of 17:57, 10 March 2015
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Rhabdomyolysis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Rhabdomyolysis causes On the Web |
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American Roentgen Ray Society Images of Rhabdomyolysis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Injuries leading to rhabdomyolysis can be due to mechanical, physical, and chemical causes.
Causes
Mechanical Causes
- Burns
- Choreoathetosis
- Compartment syndrome
- Compression by a tourniquet left for too long
- Crush trauma
- Excessive exertion
- Intractable convulsions
- Local muscle compression due to comatose states
- Rigidity due to neuroleptic malignant syndrome
- Surgery
Physical causes
- Electric current
- Extreme physical exertion (although most heavy exercise does not cause kidney damage)[1]
- High fever or hyperthermia
Chemical causes
- Alcohol
- Anoxia of the muscle (e.g., Bywaters' syndrome, toxin- and drug-related)
- Antibiotics
- Any drug that directly or indirectly impairs the production or use of adenosine triphosphate (ATP) by skeletal muscle, or increases energy requirements so as to exceed ATP production, can cause rhabdomyolysis.[2]
- Certain mushrooms like Tricholoma equestre
- Electrolyte abnormalities
- Endocrinopathy
- First-generation H1-receptor antagonists (e.g., diphenhydramine)
- Heritable muscle enzyme deficiencies
- Metabolic disorders,
- Skeletal muscle relaxants that are consumed in overdose are rarely associated with this condition.[3]
- Statin
- Various animal toxins
- Theophylline
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Acetaminophen and Oxycodone, Cytarabine, Diphenhydramine, Entacapone, Felbamate, Iodixanol, Isotretinoin, lamivudine, Sorafenib, Sulfasalazine, Trospium |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ Clarkson P, Kearns A, Rouzier P, Rubin R, Thompson P (2006). "Serum creatine kinase levels and renal function measures in exertional muscle damage". Med Sci Sports Exerc. 38 (4): 623–7. PMID 16679975.
- ↑ Larbi EB (1998). "Drug-induced rhabdomyolysis". Annals of Saudi medicine. 18 (6): 525–30. PMID 17344731.
- ↑ Chabria SB (2006). "Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity". Journal of occupational medicine and toxicology (London, England). 1: 16. doi:10.1186/1745-6673-1-16. PMID 16846511.