Muscle weakness causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vishnu Vardhan Serla M.B.B.S. [2]

Causes

Causes in Organ System

Cardiovascular	Peripheral Arterial Disease,
Chemical / poisoning	Cadmium poisoning, Dicamba, Fluoride poisoning, Hexane-2,5-dione, Temik
Dermatologic	No underlying causes
Drug Side Effect	3-Quinuclidinyl benzilate, Acamprosate (patient information), Acitretin (patient information), Aluminum Hydroxide (patient information), Amiloride and Hydrochlorothiazide (patient information), Amiodarone Oral (patient information), Beclomethasone Oral Inhalation (patient information), Benztropine Mesylate Oral (patient information), Bezafibrate (patient information), Brompheniramine (patient information), Budesonide Inhalation Powder (patient information), Chloroquine Phosphate Oral (patient information), Chlorothiazide (patient information), Chlorpheniramine (patient information), Chlorthalidone (patient information), Ciclesonide Nasal Spray (patient information), Clofibrate (patient information), Colistimethate Injection (patient information), Cyanocobalamin Injection (patient information), Cyproheptadine (patient information), Cytarabine (patient information), Daptomycin, Desipramine (patient information), Dexamethasone Oral (patient information), Dextroamphetamine and Amphetamine (patient information), Dicyclomine (patient information), Diphenhydramine Oral (patient information), Donepezil (patient information), Dorzolamide and Timolol Ophthalmic (patient information), Doxazosin (patient information), Doxylamine (patient information), Eribulin, Ergotamine tartrate, Ezetimibe (patient information), Fexofenadine and Pseudoephedrine (patient information), Fludrocortisone Acetate (patient information), Flunisolide Nasal Inhalation (patient information), Fluticasone and Salmeterol Oral Inhalation (patient information), Fluvastatin (patient information), Galantamine (patient information), Gemeprost, Glucocorticoids, Hydrochlorothiazide (patient information), Hydrocortisone Injection (patient information), Hydrocortisone Oral (patient information), Hydroxychloroquine (patient information), Hydroxyzine (patient information), Imiquimod (patient information), Insulin lispro injection (patient information), Interferon Beta-1b Injection (patient information), Ixabepilone, lamivudine, Leflunomide (patient information), Letrozole (patient information), Levalbuterol Oral Inhalation (patient information), Lisinopril and Hydrochlorothiazide (patient information), Lithium (patient information), Loprazolam, Lormetazepam, Lovastatin (patient information), Mepyramine, Mepenzolate, Methyclothiazide (patient information), Methyldopa and Hydrochlorothiazide (patient information), Methylprednisolone Oral (patient information), Metolazone (patient information), Nitrazepam, Nitrofurantoin (patient information), Oxaprozin, Oxcarbazepine (patient information), Pralidoxime, Pramipexole (patient information), Pravastatin (patient information), Prazosin and polythiazide (patient information), Prednisone, Procyclidine (patient information), Pseudoephedrine and triprolidine (patient information), Pyridostigmine (patient information), Reserpine, hydralazine, and hydrochlorothiazide (patient information), Riluzole (patient information), Rosuvastatin (patient information), Salmeterol oral inhalation (patient information), Selegiline (patient information), Spironolactone (patient information), Tamoxifen (patient information), Telbivudine (patient information), Teriparatide (rDNA origin) Injection (patient information), Tocopherol, Topiramate, Trastuzumab (patient information), Triamcinolone Nasal Inhalation (patient information), Triamterene (patient information), Trimeprazine (patient information), Zoledronic Acid Injection (patient information)
Ear Nose Throat	Acute viral nasopharyngitis (common cold)
Endocrine	Addison's disease, Cushing's syndrome, Graves' Disease, Hyperaldosteronism, Hyperpituitarism, Hyperthyroidism, Hypothyroidism, Kennedy disease, Thyrotoxicosis
Environmental	No underlying causes
Gastroenterologic	Cirrhosis
Genetic	Bassen-Kornzweig syndrome, Becker's muscular dystrophy, Carnitine palmitoyltransferase I deficiency, Dejerine Sottas syndrome, Devic's disease, Engelmann syndrome, Glutaric aciduria type 1, Glycogen storage disease type II, GM1 gangliosidoses, Hereditary inclusion body myopathy, Hereditary spastic paraplegia, Metachromatic leukodystrophy, Nemaline myopathy, Phosphofructokinase deficiency, Primary carnitine deficiency, Pyruvate carboxylase deficiency, Sandhoff disease, Walker-Warburg syndrome
Hematologic	Acute intermittent porphyria, Variegate porphyria
Iatrogenic	No underlying causes
Infectious Disease	Botulism, Group A streptococcal infection, HIV, Influenza, Polymyositis, Pott's disease, Rhinovirus
Musculoskeletal / Ortho	Arthrogryposis, Congenital muscular dystrophy, Congenital myasthenic syndrome, Congenital myopathy, Dermatomyositis, Diabetic amyotrophy, Duchenne muscular dystrophy, Emery-Dreifuss Muscular Dystrophy, Facioscapulohumeral muscular dystrophy, Inclusion body myositis, Rhabdomyolysis, Spondylosis
Neurologic	Accessory nerve disorder, Acute peripheral neuropathy, Amyotrophic lateral sclerosis, Arnold-Chiari malformation, Chronic inflammatory demyelinating polyneuropathy, Diabetic neuropathy, Epidural hematoma, Friedreich's ataxia, Guillain-Barre syndrome, Juvenile primary lateral sclerosis, Machado-Joseph disease, Marinesco-Sjogren syndrome, Motor neurone disease, Multiple sclerosis, Myasthenia gravis, Peripheral neuropathy, Sturge-Weber syndrome, Tabes dorsalis
Nutritional / Metabolic	3-Methylglutaconic aciduria, Guanidinoacetate methyltransferase deficiency, Metabolic acidosis, Vitamin D deficiency
Obstetric/Gynecologic	No underlying causes
Oncologic	Adrenal carcinoma
Opthalmologic	No underlying causes
Overdose / Toxicity	Benztropine Mesylate Oral (patient information), Fexofenadine and Pseudoephedrine (patient information), Galantamine (patient information), Salmeterol oral inhalation (patient information), Topiramate
Psychiatric	Anorexia nervosa, Bulimia nervosa, Tension myositis syndrome
Pulmonary	Hopkins syndrome
Renal / Electrolyte	Hypercalcemia, Hyperkalaemic periodic paralysis, Hypermagnesemia, Hypermethioninemia, Hypokalemic periodic paralysis, Hypomagnesemia, Hypophosphatemia, Uremia
Rheum / Immune / Allergy	Congenital myasthenic syndrome, Graves' Disease, Krabbe disease, Lambert-Eaton myasthenic syndrome, Rheumatoid Arthritis, Scleroderma, Sjogren's Syndrome
Sexual	No underlying causes
Trauma	Brachial plexus injury
Urologic	No underlying causes
Miscellaneous	Alcoholic polyneuropathy, Chronic fatigue syndrome, Mitochondrial trifunctional protein deficiency, Spinal cord injury, Spinal disc herniation, Spinal stenosis

Causes in Alphabetical Order

3-Methylglutaconic aciduria 3-Quinuclidinyl benzilate Acamprosate Accessory nerve disorder Acitretin Acute intermittent porphyria Acute peripheral neuropathy Acute viral nasopharyngitis (common cold) Addison's disease Adrenal carcinoma Alcoholic polyneuropathy Aluminum Hydroxide Amiloride and Hydrochlorothiazide Amiodarone Oral Amyotrophic lateral sclerosis Anorexia nervosa Arnold-Chiari malformation Arthrogryposis Autism Bassen-Kornzweig syndrome Becker's muscular dystrophy Beclomethasone Oral Inhalation Benztropine Mesylate Oral Bezafibrate Botulism Brachial plexus injury Brompheniramine Budesonide Inhalation Powder Bulimia nervosa Cadmium poisoning Carnitine palmitoyltransferase I deficiency Chloroquine Phosphate Oral Chlorothiazide Chlorpheniramine Chlorthalidone Chronic fatigue syndrome Chronic inflammatory demyelinating polyneuropathy Ciclesonide Nasal Spray Cirrhosis Clofibrate Colistimethate Injection Congenital muscular dystrophy Congenital myasthenic syndrome Congenital myopathy Connective tissue disease Cushing's syndrome Cyanocobalamin Injection Cyproheptadine Cytarabine Daptomycin Decompression sickness Dejerine Sottas syndrome Dermatomyositis Desipramine Devic's disease Dexamethasone Oral Dextroamphetamine and Amphetamine Diabetic amyotrophy Diabetic neuropathy Dicamba Dicyclomine Diphenhydramine Oral Donepezil Dorzolamide and Timolol Ophthalmic Doxazosin Doxylamine Duchenne muscular dystrophy Emery-Dreifuss Muscular Dystrophy Engelmann syndrome Epidural hematoma Eribulin Ergotamine tartrate Exercise intolerance Ezetimibe Facioscapulohumeral muscular dystrophy Fexofenadine and Pseudoephedrine Fludrocortisone Acetate Flunisolide Nasal Inhalation Fluoride poisoning Fluticasone and Salmeterol Oral Inhalation Fluvastatin Frailty syndrome Friedreich's ataxia Galantamine Gemeprost Glucocorticoids Glutaric aciduria type 1 Glycogen storage disease type II GM1 gangliosidoses Graves' Disease Group A streptococcal infection Guanidinoacetate methyltransferase deficiency Guillain-Barre syndrome Hereditary inclusion body myopathy Hereditary spastic paraplegia Herpes zoster Hexane-2,5-dione HIV Hopkins syndrome Hydrochlorothiazide Hydrocortisone Injection Hydrocortisone Oral Hydroxychloroquine Hydroxyzine Hyperaldosteronism Hypercalcemia Hyperkalaemic periodic paralysis

Hyperkalemia Hypermagnesemia Hypermethioninemia Hyperpituitarism Hyperthyroidism Hypoglycemia Hypokalemic periodic paralysis Hypomagnesemia Hypophosphatemia Hypothyroidism Imiquimod Inclusion body myositis Influenza Interferon Beta-1b Injection Juvenile dermatomyositis Juvenile primary lateral sclerosis Kennedy disease Krabbe disease Lambert-Eaton myasthenic syndrome Leflunomide Letrozole Levalbuterol Oral Inhalation Limb-girdle muscular dystrophy Lisinopril and Hydrochlorothiazide Lithium Loprazolam Lormetazepam Lovastatin Low-carbohydrate diet Machado-Joseph disease Marinesco-Sjogren syndrome Mepyramine Metabolic acidosis Metachromatic leukodystrophy Methyclothiazide Methyldopa and Hydrochlorothiazide Methylprednisolone Oral Metolazone Mitochondrial trifunctional protein deficiency Motor neurone disease Multiple sclerosis Myasthenia gravis Nelson's syndrome Nemaline myopathy Nitrazepam Nitrofurantoin Oxaprozin Oxcarbazepine Peripheral Arterial Disease Peripheral neuropathy Phosphofructokinase deficiency Poliomyelitis Polymyositis Postherpetic neuralgia Post-polio syndrome Pott's disease Pralidoxime Pramipexole Pravastatin Prazosin and polythiazide Prednisone Primary carnitine deficiency Primary hyperparathyroidism Primary lateral sclerosis Procyclidine Pseudoephedrine and triprolidine Pyridostigmine Pyruvate carboxylase deficiency Reserpine, hydralazine, and hydrochlorothiazide Rhabdomyolysis Rhabdomyolysis Rheumatoid Arthritis Rhinovirus Riluzole Rosuvastatin Salmeterol oral inhalation Sandhoff disease Schilder's disease Scleroderma Selegiline Sjogren's Syndrome Small fiber peripheral neuropathy Somatization disorder Spinal cord injury Spinal disc herniation Spinal stenosis Spironolactone Spondylosis Sturge-Weber syndrome Tabes dorsalis Tamoxifen Telbivudine Temik Tension myositis syndrome Teriparatide (rDNA origin) Injection Thyrotoxicosis Tocopherol Topiramate Trastuzumab Triamcinolone Nasal Inhalation Triamterene Trimeprazine Uremia Variegate porphyria Vitamin D deficiency Walker-Warburg syndrome Zoledronic Acid Injection