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| __NOTOC__
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| {{imipenem cilastatin}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overview==
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| Imipenem/cilastatin is a broad spectrum [[beta-lactam]] [[antibiotic]] containing equal quantities of [[imipenem]] and [[cilastatin]]. It is related to the penicillin/cephalosporin family of antibiotics but is classified as belonging to the [[carbapenem]] class. It has the ability to kill a wide variety of bacteria. It works by interfering with their ability to form cell walls, and therefore the bacteria break up and die.
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| ==Category==
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| Carbapenem
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| ==US Brand Names==
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| PRIMAXIN<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[imipenem cilastatin description|Description]]'''
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| '''| [[imipenem cilastatin clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[imipenem cilastatin microbiology|Microbiology]]'''
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| '''| [[imipenem cilastatin indications and usage|Indications and Usage]]'''
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| '''| [[imipenem cilastatin contraindications|Contraindications]]'''
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| '''| [[imipenem cilastatin warnings and precautions|Warnings and Precautions]]'''
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| '''| [[imipenem cilastatin adverse reactions|Adverse Reactions]]'''
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| '''| [[imipenem cilastatin overdosage|Overdosage]]'''
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| '''| [[imipenem cilastatin dosage and administration|Dosage and Administration]]'''
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| '''| [[imipenem cilastatin compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
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| '''| [[imipenem cilastatin directions for use|Directions For Use]]'''
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| '''| [[imipenem cilastatin how supplied|How Supplied]]'''
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| '''| [[imipenem cilastatin labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Imipenem cilastatin belongs to the carbapenem class of antimicrobials. Imipenem cilastatin exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Imipenem cilastatin inactivates multiple essential [[penicillin-binding protein]]s (PBPs) resulting in inhibition of [[cell wall]] synthesis with subsequent cell death. In [[E. coli]] and [[P. aeruginosa]], imipenem cilastatin binds to PBP 2, which is involved in the maintenance of cell shape, as well as to PBPs 3 and 4.
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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