Motavizumab: Difference between revisions

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List of terms related to Motavizumab

Motavizumab
Monoclonal antibody
Type	Whole antibody
Source	Template:Infobox drug/mab source
Target	RSV glycoprotein F
Clinical data
Trade names	Numax
Routes of; administration	i.v.
ATC code	J06BB17 (WHO) ;
Pharmacokinetic data
Protein binding	None
Identifiers
CAS Number	677010-34-3 ;
ChemSpider	NA ;
UNII	50Y163LK8Q;
KEGG	D06621 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C6476H10014N1706O2008S48
Molar mass	Approximately 148 kDa
(what is this?) (verify)

VisualWikitext

Revision as of 13:28, 7 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Motavizumab (proposed INN, trade name Numax) is a humanized monoclonal antibody. It is being investigated by MedImmune (today a subsidiary of AstraZeneca) for the prevention of respiratory syncytial virus infection in high-risk infants. As of September 2009^[update], it is undergoing Phase II and III clinical trials.^[1]

In June 2010, the FDA Antiviral Drugs Advisory Committee declined to endorse MedImmune's request for licensure of Motavizumab in a 14 to 3 decision. The members of that panel cited several reasons for the decision, and many were concerned that "we're not looking at a product that has evidence of superiority in terms of efficacy" when compared to the already available monoclonal antibody Palivizumab.^[2]

In December 2010, AstraZeneca in a stock market statement stated that it would be writing down $445m (£286m) after discontinuing a key development programme for Motavizumab. The company stated that it would no longer develop Motavizumab for the prevention of respiratory syncytial virus (RSV), and as a result was withdrawing its licence application to the US Food and Drug Administration. It added that it would continue to develop Motavizumab for other treatments of RSV.^[3]

References

↑ ClinicalTrials.gov
↑ "FDA Panel Nixes Licensing Request for Motavizumab". Medscape. 3 June 2010. Retrieved 2014-03-02.
↑ "AstraZeneca halts work on Motavizumab drug". BBC News. 21 December 2010. Retrieved 2010-12-21.

Template:Monoclonals for infectious disease and toxins Template:Immune sera and immunoglobulins Template:AstraZeneca

Template:Antiinfective-drug-stub

This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it.

[1] ClinicalTrials.gov

[2] "FDA Panel Nixes Licensing Request for Motavizumab". Medscape. 3 June 2010. Retrieved 2014-03-02.

[3] "AstraZeneca halts work on Motavizumab drug". BBC News. 21 December 2010. Retrieved 2010-12-21.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{drugbox-mab
+{{Drugbox
-| image =
+| Verifiedfields = changed
-| source = [[Human]]
+| Watchedfields = changed
-| target =
+| verifiedrevid = 458284116
-| CAS_number        = 677010-34-3
-| ATC_prefix        =
+<!--Monoclonal antibody data-->
-| ATC_suffix        =
+| type = mab
-| PubChem           =
+| mab_type = mab
-| DrugBank          =
+| source = zu/o
-| chemical_formula  =
+| target = [[respiratory syncytial virus|RSV]] glycoprotein F
-| molecular_weight  = Approximately 148 [[Atomic mass unit|kDa]]
-| bioavailability   =
+<!--Clinical data-->
-| protein_bound     =
+| tradename = Numax
-| metabolism        =
+| pregnancy_AU =
-| elimination_half-life =
+| pregnancy_US =
-| excretion         =
+| pregnancy_category =
-| pregnancy_AU      =
+| legal_AU =
-| pregnancy_US      =
+| legal_CA =
-| pregnancy_category=
+| legal_UK =
-| legal_AU          =
+| legal_US =
-| legal_CA          =
+| legal_status =
-| legal_UK          =
+| routes_of_administration = i.v.
-| legal_US          =
-| legal_status      =
+<!--Pharmacokinetic data-->
-| routes_of_administration =
+| bioavailability =
+| protein_bound = None
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|changed|??}}
+| CAS_number = 677010-34-3
+| ATC_prefix = J06
+| ATC_suffix = BB17
+| PubChem =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 50Y163LK8Q
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D06621
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = NA
+<!--Chemical data-->
+| C=6476 | H=10014 | N=1706 | O=2008 | S=48
+| molecular_weight = Approximately 148 [[Atomic mass unit|kDa]]
 }}
+__NOTOC__
-'''Motavizumab''' (proposed [[International Nonproprietary Name|INN]], trade name '''Numax''') is a [[Humanize|humanized]] [[monoclonal antibody]]. It is [[As of 2007|currently]] being investigated by [[MedImmune]] for the prevention of [[respiratory syncytial virus]] infection in high-risk [[infant]]s.
+{{SI}}
-==External links==
+{{CMG}}
-*[http://www.medimmune.com/pipeline/numax.asp MedImmune]
+==Overview==
+'''Motavizumab''' (proposed [[International Nonproprietary Name|INN]], trade name '''Numax''') is a [[humanized monoclonal antibody]]. It is being investigated by [[MedImmune]] (today a subsidiary of [[AstraZeneca]]) for the prevention of [[respiratory syncytial virus]] infection in high-risk [[infant]]s. {{As of|September 2009}}, it is undergoing Phase II and III [[clinical trials]].<ref>[http://www.clinicaltrials.gov/ct2/results?term=motavizumab ClinicalTrials.gov]</ref>
+In June 2010, the FDA Antiviral Drugs Advisory Committee declined to endorse MedImmune's request for licensure of Motavizumab in a 14 to 3 decision. The members of that panel cited several reasons for the decision, and many were concerned that "we're not looking at a product that has evidence of superiority in terms of efficacy" when compared to the already available monoclonal antibody Palivizumab.<ref>{{cite web|url=http://www.medscape.com/viewarticle/722903|title=FDA Panel Nixes Licensing Request for Motavizumab|publisher=Medscape|date=3 June 2010|accessdate=2014-03-02}}</ref>
+In December 2010, AstraZeneca in a stock market statement stated that it would be writing down $445m (£286m) after discontinuing a key development programme for Motavizumab. The company stated that it would no longer develop Motavizumab for the prevention of [[respiratory syncytial virus]] (RSV), and as a result was withdrawing its licence application to the US [[Food and Drug Administration]]. It added that it would continue to develop Motavizumab for other treatments of RSV.<ref>{{cite web|url=http://www.bbc.co.uk/news/business-12047666|title=AstraZeneca halts work on Motavizumab drug|publisher=BBC News|date=21 December 2010|accessdate=2010-12-21}}</ref>
+==References==
+{{reflist|2}}
+{{Monoclonals for infectious disease and toxins}}
+{{Immune sera and immunoglobulins}}
+{{AstraZeneca}}
+[[Category:AstraZeneca]]
+[[Category:Drug]]
+{{antiinfective-drug-stub}}
 {{monoclonal-antibody-stub}}
-{{humanizedmonoclonals}}
-[[Category:Monoclonal antibodies]]

Motavizumab: Difference between revisions

Revision as of 13:28, 7 April 2015

Overview

References

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