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'''Oxypertine''' ('''Equipertine''', '''Forit''', '''Integrin''', '''Lanturil''', '''Lotawin''', '''Opertil''') is an [[antipsychotic]] used in the treatment of [[schizophrenia]].<ref name="isbn0-412-54090-8">{{cite book | author = | title = Dictionary of organic compounds | publisher = Chapman & Hall | location = London | year = 1996 | pages = | isbn = 0-412-54090-8 | oclc = | doi = | url = http://books.google.com/?id=5S_uhYzKWisC&lpg=PA5038&dq=oxypertine%20forit&pg=PA5038#v=onepage&q= | author1 = Hall, Chapman and | author2 = Rhodes, P. H}}</ref> Chemically, it is an [[indole]] [[chemical derivative|derivative]] similarly to [[molindone]] and a member of the [[phenylpiperazine]] class.<ref name="pmid4972600">{{cite journal |author=Breulet M, Labar P, Delree C, Collard J, Bobon J |title=[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties] |language=French |journal=Acta Neurol Psychiatr Belg |volume=68 |issue=2 |pages=116–27 |date=February 1968 |pmid=4972600 |doi= |url=}}</ref> Like [[reserpine]] and [[tetrabenazine]], oxypertine depletes [[catecholamine]]s, though not [[serotonin]], possibly underlying its neuroleptic efficacy.<ref name="pmid5362847">{{cite journal | author = Bak IJ, Hassler R, Kim JS | title = Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin | journal = Zeitschrift Für Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948) | volume = 101 | issue = 3 | pages = 448–62 | year = 1969 | pmid = 5362847 | doi = | url = }}</ref> | '''Oxypertine''' ('''Equipertine''', '''Forit''', '''Integrin''', '''Lanturil''', '''Lotawin''', '''Opertil''') is an [[antipsychotic]] used in the treatment of [[schizophrenia]].<ref name="isbn0-412-54090-8">{{cite book | author = | title = Dictionary of organic compounds | publisher = Chapman & Hall | location = London | year = 1996 | pages = | isbn = 0-412-54090-8 | oclc = | doi = | url = http://books.google.com/?id=5S_uhYzKWisC&lpg=PA5038&dq=oxypertine%20forit&pg=PA5038#v=onepage&q= | author1 = Hall, Chapman and | author2 = Rhodes, P. H}}</ref> Chemically, it is an [[indole]] [[chemical derivative|derivative]] similarly to [[molindone]] and a member of the [[phenylpiperazine]] class.<ref name="pmid4972600">{{cite journal |author=Breulet M, Labar P, Delree C, Collard J, Bobon J |title=[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties] |language=French |journal=Acta Neurol Psychiatr Belg |volume=68 |issue=2 |pages=116–27 |date=February 1968 |pmid=4972600 |doi= |url=}}</ref> Like [[reserpine]] and [[tetrabenazine]], oxypertine depletes [[catecholamine]]s, though not [[serotonin]], possibly underlying its neuroleptic efficacy.<ref name="pmid5362847">{{cite journal | author = Bak IJ, Hassler R, Kim JS | title = Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin | journal = Zeitschrift Für Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948) | volume = 101 | issue = 3 | pages = 448–62 | year = 1969 | pmid = 5362847 | doi = | url = }}</ref> | ||
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{{Antipsychotics}} | {{Antipsychotics}} | ||
{{Tryptamines}} | {{Tryptamines}} | ||
[[Category:Piperazines]] | [[Category:Piperazines]] | ||
[[Category:Indoles]] | [[Category:Indoles]] | ||
[[Category:Phenol ethers]] | [[Category:Phenol ethers]] | ||
[[Category:Drug]] | [[Category:Drug]] | ||
Revision as of 14:03, 7 April 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.[1] Chemically, it is an indole derivative similarly to molindone and a member of the phenylpiperazine class.[2] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.[3]
See also
References
- ↑ Hall, Chapman and; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.
- ↑ Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurol Psychiatr Belg (in French). 68 (2): 116–27. PMID 4972600.
- ↑ Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift Für Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948). 101 (3): 448–62. PMID 5362847.