Edrecolomab: Difference between revisions

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Edrecolomab
Monoclonal antibody
Type	Whole antibody
Source	Template:Infobox drug/mab source
Target	EpCAM (17-1A)
Clinical data
Trade names	Panorex
ATC code	L01XC01 (WHO) ;
Identifiers
CAS Number	156586-89-9 ;
ChemSpider	NA ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
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VisualWikitext

Revision as of 14:06, 7 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Edrecolomab (MAb17-1A, trade name Panorex) is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas.

Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma (with metastasis to the lymph nodes).^[1]^[2] However, when put to a phase III study (2,761 patients) it did not provide any benefit when compared to conventional chemotherapeutic agents.^[3] No effect has been demonstrated for stage II (locally advanced cancer without spread to the lymph nodes) colon cancer.^[4]

Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.

References

↑ Riethmüller G, Schneider-Gädicke E, Schlimok G et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet. 1994;343(8907):1177-83. PMID 7909866
↑ Fields AL, Keller AM, Schwartzberg L et al. Edrecolomab (17-1A antibody) in combination with 5-fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised North American phase III study (abstract). Proc Am Soc Clin Oncol. 2002;21:128a.
↑ Punt CJ, Nagy A, Douillard JY et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002;360(9334):671-7. doi:10.1016/S0140-6736(02)09836-7 PMID 12241873
↑ Colacchio TA, Niedzwicki D, Compton C, et al. Phase III trial of adjuvant immunotherapy with MoAb 17-1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). Proc Am Soc Clin Oncol. 2004;23:251a.

Template:Extracellular chemotherapeutic agents Template:Monoclonals for tumors

This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it.

Template:Antineoplastic-drug-stub

[Lancet1994-1] Riethmüller G, Schneider-Gädicke E, Schlimok G et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet. 1994;343(8907):1177-83. PMID 7909866

[Proc2002-2] Fields AL, Keller AM, Schwartzberg L et al. Edrecolomab (17-1A antibody) in combination with 5-fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised North American phase III study (abstract). Proc Am Soc Clin Oncol. 2002;21:128a.

[3] Punt CJ, Nagy A, Douillard JY et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002;360(9334):671-7. doi:10.1016/S0140-6736(02)09836-7 PMID 12241873

[stageII-4] Colacchio TA, Niedzwicki D, Compton C, et al. Phase III trial of adjuvant immunotherapy with MoAb 17-1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). Proc Am Soc Clin Oncol. 2004;23:251a.

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@@ Line 1: / Line 1: @@
-'''Edrecolomab''' (MAb17-1A) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with colorectal carcinoma. However, when put to a phase III study (2,761 patients) it did not provide any benefit when compared to conventional chemotherapeutic agents
+{{Drugbox
-<ref>''Punt CJ et al, Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. The Lancet, Volume 360, Issue 9334, Pages 671-677''   [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12241873&query_hl=1&itool=pubmed_DocSum]
+| Verifiedfields = changed
-</ref>. It is important to mention that edrecolomab was well tolerated and as such research has now concentrated on whether it can be of any use in other forms of cancer.
+| verifiedrevid = 461092781
+| image =
+<!--Monoclonal antibody data-->
+| type = mab
+| mab_type = mab
+| source = o
+| target = [[EpCAM]] (17-1A)
+<!--Clinical data-->
+| tradename = Panorex
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = NA
+| CAS_number_Ref = {{cascite|changed|??}}
+| CAS_number = 156586-89-9
+| ATC_prefix = L01
+| ATC_suffix = XC01
+| PubChem =
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+<!--Chemical data-->
+| chemical_formula =
+| molecular_weight =
+}}
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Edrecolomab''' (MAb17-1A, trade name '''Panorex''') is a mouse-derived [[monoclonal antibody]] targeting the cell-surface [[glycoprotein]] [[EpCAM]] (17-1A), which is expressed on [[epithelium|epithelial tissues]] and on various [[carcinoma]]s.
+Preliminary studies had shown promise of a possible use in patients with stage III [[colorectal carcinoma]] (with [[metastasis]] to the [[lymph nodes]]).<ref name="Lancet1994">Riethmüller G, Schneider-Gädicke E, Schlimok G ''et al.'' Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. ''Lancet''. 1994;'''343(8907)''':1177-83. PMID 7909866</ref><ref name="Proc2002">Fields AL, Keller AM, Schwartzberg L ''et al.'' Edrecolomab (17-1A antibody) in combination with 5-fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised North American phase III study (abstract). ''Proc Am Soc Clin Oncol''. 2002;'''21''':128a.</ref> However, when put to a phase III study (2,761 patients) it did not provide any benefit when compared to conventional [[chemotherapy|chemotherapeutic]] agents.<ref>Punt CJ, Nagy A, Douillard JY ''et al.'' Edrecolomab alone or in combination with [[fluorouracil]] and [[folinic acid]] in the adjuvant treatment of stage III colon cancer: a randomised study. ''Lancet''. 2002;'''360(9334)''':671-7. {{DOI|10.1016/S0140-6736(02)09836-7}} PMID 12241873</ref> No effect has been demonstrated for stage II (locally advanced cancer without spread to the lymph nodes) colon cancer.<ref name="stageII">Colacchio TA, Niedzwicki D, Compton C, ''et al.'' Phase III trial of adjuvant immunotherapy with MoAb 17-1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). ''Proc Am Soc Clin Oncol''. 2004;'''23''':251a.</ref>
+Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.
 ==References==
-<references/>
+{{reflist|2}}
+{{Extracellular chemotherapeutic agents}}
+{{Monoclonals for tumors}}
-{{mousemonoclonals}}
+[[Category:Monoclonal antibodies for tumors]]
+[[Category:Drug]]
-[[Category:Monoclonal antibodies]]
+{{monoclonal-antibody-stub}}
-{{WikiDoc Help Menu}}
+{{antineoplastic-drug-stub}}
-{{WikiDoc Sources}}

Edrecolomab: Difference between revisions

Revision as of 14:06, 7 April 2015

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