Demecarium bromide: Difference between revisions

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<div style="float: right;">
| IUPAC_name = trimethyl-[3-[methyl-[10-[methyl- (3-trimethylammoniophenoxy) carbonyl-amino] decyl] carbamoyl] oxyphenyl]-ammonium dibromide
[[File:Demecarium.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div>
| image = Demecarium bromide.png
 
| CAS_number = 56-94-0
| ATC_prefix = S01
| ATC_suffix = EB04
| ATC_supplemental =
| PubChem = 5965
| DrugBank = APRD00905
| C=32 | H=52 | Br=2 | N=4 | O=4
| molecular_weight = 716.588 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
| routes_of_administration =
}}
{{CMG}}
__NOTOC__
__NOTOC__


{{SI}}
{{CMG}}


==Overview==
==Overview==
'''Demecarium''' is a [[parasympathomimetic]] that acts as an [[acetylcholinesterase inhibitor]]. It is one of several topical (applied directly to the affected area) medications used to reduce elevated [[intraocular pressure]] (IOP) associated with primary glaucoma in cats, dogs, and other animals.<ref>{{cite journal | author = Ward D, Abney K, Oliver J | title = The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. | journal = Vet Ophthalmol | volume = 6 | issue = 1 | pages = 23–5 | year = 2003 | pmid = 12641839 | doi = 10.1046/j.1463-5224.2003.00257.x}}</ref><ref>{{cite journal | author = Krohne S | title = Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. | journal = Am J Vet Res | volume = 55 | issue = 12 | pages = 1729–33 | year = 1994 | pmid = 7887518}}</ref><ref>{{cite journal | author = Gum G, Gelatt K, Gelatt J, Jones R | title = Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. | journal = Am J Vet Res | volume = 54 | issue = 2 | pages = 287–93 | year = 1993 | pmid = 8430939}}</ref>


'''Demecarium bromide''' is a compound classified by the [[World Health Organization]] as a [[parasympathomimetic]].
== See also ==
 
==See also==
* [[Diisopropylfluorophosphate]]
* [[Diisopropylfluorophosphate]]
* [[Intraocular pressure]]
* [[Intraocular pressure]]
* [[Glaucoma]]
* [[Glaucoma]]


==External links==
== References ==
* {{cite journal | author = Ward D, Abney K, Oliver J | title = The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. | journal = Vet Ophthalmol | volume = 6 | issue = 1 | pages = 23-5 | year = 2003 | pmid = 12641839}}
{{Reflist|2}}
* {{cite journal | author = Krohne S | title = Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. | journal = Am J Vet Res | volume = 55 | issue = 12 | pages = 1729-33 | year = 1994 | pmid = 7887518}}
* {{cite journal | author = Gum G, Gelatt K, Gelatt J, Jones R | title = Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. | journal = Am J Vet Res | volume = 54 | issue = 2 | pages = 287-93 | year = 1993 | pmid = 8430939}}


{{Antiglaucoma preparations and miotics}}
{{Opthalmologicals}}
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Revision as of 15:13, 7 April 2015

This image is provided by the National Library of Medicine.


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals.[1][2][3]

See also

References

  1. Ward D, Abney K, Oliver J (2003). "The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs". Vet Ophthalmol. 6 (1): 23–5. doi:10.1046/j.1463-5224.2003.00257.x. PMID 12641839.
  2. Krohne S (1994). "Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs". Am J Vet Res. 55 (12): 1729–33. PMID 7887518.
  3. Gum G, Gelatt K, Gelatt J, Jones R (1993). "Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma". Am J Vet Res. 54 (2): 287–93. PMID 8430939.

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