Bromhexine

{{Drugbox | Verifiedfields = changed | verifiedrevid = 443272001 | IUPAC_name = 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline | image =File:Bromhexine-PlainPNG.png | image2 =File:Bromhexine 3D.png

| tradename = | Drugs.com = International Drug Names | pregnancy_category = A (Aus) | legal_status = | routes_of_administration =

| bioavailability = 75-80% | metabolism = | elimination_half-life = 12 hr | excretion =

| CAS_number_Ref =  ^Y | CAS_number = 3572-43-8 | ATC_prefix = R05 | ATC_suffix = CB02 | PubChem = 2442 | ChemSpiderID_Ref =  ^Y | ChemSpiderID = 2348 | UNII_Ref =  ^Y | UNII = Q1J152VB1P | DrugBank_Ref =  ^N | DrugBank = DB09019 | KEGG_Ref =  ^Y | KEGG = D07542 | ChEBI_Ref =  ^N | ChEBI = 77032 | ChEMBL_Ref =  ^Y | ChEMBL = 253376

| C=14 | H=20 | Br=2 | N=2 | molecular_weight = 376.13 | smiles = Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2 | InChI = 1/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 | InChIKey = OJGDCBLYJGHCIH-UHFFFAOYAY | StdInChI_Ref =  ^Y | StdInChI = 1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 | StdInChIKey_Ref =  ^Y | StdInChIKey = OJGDCBLYJGHCIH-UHFFFAOYSA-N }}

WikiDoc Resources for Bromhexine
Articles
Most recent articles on Bromhexine Most cited articles on Bromhexine Review articles on Bromhexine Articles on Bromhexine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Bromhexine Images of Bromhexine Photos of Bromhexine Podcasts & MP3s on Bromhexine Videos on Bromhexine
Evidence Based Medicine
Cochrane Collaboration on Bromhexine Bandolier on Bromhexine TRIP on Bromhexine
Clinical Trials
Ongoing Trials on Bromhexine at Clinical Trials.gov Trial results on Bromhexine Clinical Trials on Bromhexine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Bromhexine NICE Guidance on Bromhexine NHS PRODIGY Guidance FDA on Bromhexine CDC on Bromhexine
Books
Books on Bromhexine
News
Bromhexine in the news Be alerted to news on Bromhexine News trends on Bromhexine
Commentary
Blogs on Bromhexine
Definitions
Definitions of Bromhexine
Patient Resources / Community
Patient resources on Bromhexine Discussion groups on Bromhexine Patient Handouts on Bromhexine Directions to Hospitals Treating Bromhexine Risk calculators and risk factors for Bromhexine
Healthcare Provider Resources
Symptoms of Bromhexine Causes & Risk Factors for Bromhexine Diagnostic studies for Bromhexine Treatment of Bromhexine
Continuing Medical Education (CME)
CME Programs on Bromhexine
International
Bromhexine en Espanol Bromhexine en Francais
Business
Bromhexine in the Marketplace Patents on Bromhexine
Experimental / Informatics
List of terms related to Bromhexine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bromhexine is a mucolytic (expectorant) agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract.

It is secretolytic, increasing the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.

Brand names

• Bisolvon
• Paxirasol
• Barkacin
• Bromhexin
• Vasican
• Bisolex
• Robitussin Chesty/Forte
• Duro-Tuss Chesty
• Benadryl Chesty/Forte
• Movex
• Bromex
• Solvex
• Mucolyte
• Brofentol
• Brofentol Plus
• Dysolvon
• Flegamina