Niperotidine: Difference between revisions

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Niperotidine
Names
	IUPAC name (Z)-N-(1,3-benzodioxol-5-ylmethyl)-N'-{2[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}-2-nitroethylene-1,1-diamine
Identifiers
CAS Number	84845-75-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1909284 ;
ChemSpider	11644617 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D07072 ;
MeSH	C073716
PubChem CID	3033952;
	InChI InChI=1S/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3 Key: VZPXHGJTEAPNAA-UHFFFAOYSA-N ; InChI=1/C20H28N4O5S/c1-23(2)11-16-4-5-17(29-16)13-30-8-7-21-20(12-24(25)26)22-10-15-3-6-18-19(9-15)28-14-27-18/h3-6,9,20-22H,7-8,10-14H2,1-2H3 Key: VZPXHGJTEAPNAA-UHFFFAOYAQ;
	SMILES CN(C)CC1=CC=C(O1)CSCCNC(=C[N+](=O)[O-])NCC2=CC3=C(C=C2)OCO3;
Properties
Chemical formula	C20H26N4O5S
Molar mass	434.50924
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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VisualWikitext

Revision as of 14:36, 8 April 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niperotidine is a histamine antagonist selective for the H₂ subtype. It was trialled as a treatment for excessive gastric acidity,^[1] but withdrawn after human trials showed liver damage.^[2]

References

↑ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
↑ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138

Template:Drugs for peptic ulcer and GORD

Template:Gastrointestinal-drug-stub

[1] Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712

[2] Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138

[1]

[2]

@@ Line 54: / Line 54: @@
 ==Overview==
 '''Niperotidine''' is a [[histamine antagonist]] selective for the [[Histamine H2 receptor|H<sub>2</sub>]] subtype. It was trialled as a treatment for excessive gastric acidity,<ref>Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. ''Italian Journal of Gastroenterology''. 1990 Oct;22(5):291-4. PMID 1983712</ref> but withdrawn after human trials showed [[hepatotoxicity|liver damage]].<ref>Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. ''Journal of Hepatology''. 1997 Sep;27(3):583-6. PMID 9314138</ref>
@@ Line 61: / Line 59: @@
 <references/>
-{{Histaminergics}}
 {{Drugs for peptic ulcer and GORD}}
 [[Category:H2 receptor antagonists]]
-[[Category:Benzodioxoles]]
+[[Category:Drug]]
-[[Category:Nitroethenes]]
 [[Category:Thioethers]]
 [[Category:Furans]]

Niperotidine: Difference between revisions

Revision as of 14:36, 8 April 2015

Overview

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