Delamanid: Difference between revisions
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==Overview== | ==Overview== | ||
'''Delamanid''' ([[United States Adopted Name|USAN]], codenamed '''OPC-67683''') is an experimental drug for the treatment of [[multi-drug-resistant tuberculosis]]. It works by blocking the synthesis of [[mycolic acid]]s in ''[[Mycobacterium tuberculosis]]'', the organism which causes tuberculosis, thus destabilising its [[cell wall]].<ref>{{cite pmid|17132069}}</ref><ref>{{cite pmid|23018916}}</ref><ref name="Spreitzer" /> | '''Delamanid''' ([[United States Adopted Name|USAN]], codenamed '''OPC-67683''') is an experimental drug for the treatment of [[multi-drug-resistant tuberculosis]]. It works by blocking the synthesis of [[mycolic acid]]s in ''[[Mycobacterium tuberculosis]]'', the organism which causes tuberculosis, thus destabilising its [[cell wall]].<ref>{{cite pmid|17132069}}</ref><ref>{{cite pmid|23018916}}</ref><ref name="Spreitzer" /> | ||
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[[Category:Tuberculosis]] | [[Category:Tuberculosis]] | ||
[[Category:Drug]] | [[Category:Drug]] | ||
Revision as of 15:19, 8 April 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Delamanid (USAN, codenamed OPC-67683) is an experimental drug for the treatment of multi-drug-resistant tuberculosis. It works by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall.[1][2][3]
In phase II clinical trials, the drug was used in combination with standard treatments, such as four or five of the drugs ethambutol, isoniazid, pyrazinamide, rifampicin, aminoglycoside antibiotics, and quinolones. Healing rates (measured as sputum culture conversion) were significantly better in patients who additionally took delamanid.[3][4]
The European Medicines Agency (EMA) recommended conditional marketing authorization for delamanid in adults with multidrug-resistant pulmonary tuberculosis without other treatment options because of resistance or tolerability. The EMA considered the data show that the benefits of delamanid outweigh the risks, but that additional studies were needed on the long-term effectiveness.[5]
See also
- PA 824, a related drug
References
- ↑ PMID 17132069 (PMID 17132069)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 23018916 (PMID 23018916)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ 3.0 3.1 H. Spreitzer (18 February 2013). "Bedaquilin". Österreichische Apothekerzeitung (in German) (4/2013): 22.
- ↑ PMID 22670901 (PMID 22670901)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ Drug Discovery & Development. EMA Recommends Two New Tuberculosis Treatments. November 22, 2013.