Rocuronium bromide: Difference between revisions
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| IUPAC_name = 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidinium bromide | | IUPAC_name = 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidinium bromide | ||
| image = Rocuronium | | image = Rocuronium Wiki Str.png | ||
<!--Clinical data--> | <!--Clinical data--> | ||
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| synonyms = <small>[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1''H''-cyclopenta[''a'']phenanthren-17-yl] acetate</small> | | synonyms = <small>[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1''H''-cyclopenta[''a'']phenanthren-17-yl] acetate</small> | ||
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==Overview== | |||
'''Rocuronium''' ('''Zemuron''', '''Esmeron''') is an [[aminosteroid]] [[Neuromuscular-blocking_drug#Non-depolarizing_blocking_agents|non-depolarizing]] [[Neuromuscular-blocking drugs|neuromuscular blocker]] or [[muscle relaxant]] used in modern [[anaesthesia]], to facilitate [[endotracheal intubation]] and to provide [[skeletal muscle]] relaxation during [[surgery]] or [[mechanical ventilation]]. | '''Rocuronium''' ('''Zemuron''', '''Esmeron''') is an [[aminosteroid]] [[Neuromuscular-blocking_drug#Non-depolarizing_blocking_agents|non-depolarizing]] [[Neuromuscular-blocking drugs|neuromuscular blocker]] or [[muscle relaxant]] used in modern [[anaesthesia]], to facilitate [[endotracheal intubation]] and to provide [[skeletal muscle]] relaxation during [[surgery]] or [[mechanical ventilation]]. | ||
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{{Cholinergics}} | {{Cholinergics}} | ||
[[Category:Drugs]] | |||
[[Category:Muscle relaxants]] | [[Category:Muscle relaxants]] | ||
[[Category:Quaternary ammonium compounds]] | [[Category:Quaternary ammonium compounds]] | ||
Latest revision as of 17:47, 8 April 2015
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| Clinical data | |
|---|---|
| Synonyms | [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | ~30% |
| Metabolism | some de-acetylation |
| Elimination half-life | 66–80 minutes |
| Excretion | Unchanged, in bile and urine |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| UNII | |
| ChEMBL | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C32H53N2O4+ |
| Molar mass | 529.774 g/mol |
  (what is this?) (verify) | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Rocuronium (Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Development
It was designed to be a weaker antagonist at the neuromuscular junction than pancuronium; hence its monoquaternary structure and its having an allyl group and a pyrrolidine group attached to the D ring quaternary nitrogen atom. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action.[1] It is marketed under the trade name of Zemuron in the United States and Esmeron in most other countries.
There is considered to be a risk of allergic reaction to the drug in some patients (particularly those with asthma), but a similar incidence of allergic reactions has been observed by using other members of the same drug class (non-depolarizing neuromuscular blocking drugs).[2]
The γ-cyclodextrin derivative sugammadex (trade name Bridion) has been recently introduced as a novel agent to reverse the action of rocuronium. [3] Sugammadex has been in use since 2009 in many European countries, however it has been turned down for approval twice by the US FDA and is currently unavailable for use in the US due to concerns over allergic reactions and bleeding. [4]
On July 27, 2012, the State of Virginia replaced pancuronium bromide, one of the three drugs used in execution by lethal injection, with rocuronium.
References
- ↑ Hunter JM (April 1996). "Rocuronium: the newest aminosteroid neuromuscular blocking drug". British Journal of Anaesthesia. 76 (4): 481–3. doi:10.1093/bja/76.4.481. PMID 8652315.
- ↑ Burburan SM, Xisto DG, Rocco PR (June 2007). "Anaesthetic management in asthma". Minerva Anestesiologica. 73 (6): 357–65. PMID 17115010.
- ↑ Naguib M (March 2007). "Sugammadex: another milestone in clinical neuromuscular pharmacology". Anesthesia and Analgesia. 104 (3): 575–81. doi:10.1213/01.ane.0000244594.63318.fc. PMID 17312211.
- ↑ McKee, Selina (September 24, 2013). "FDA turns down Merck & Co's sugammadex again". PharmaTimes.
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