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{{Drugbox
{{Drugbox
| IUPAC_name       = (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
| verifiedrevid = 447917039
| image             = Oxaceprol.png
| IUPAC_name = (4''R'')-1-acetyl-4-hydroxy-<small>L</small>-proline
| width             = 120px
| image = Oxaceprol.svg
| CAS_number        = 33996-33-7
| width = 200px
| ATC_prefix        = D11
 
| ATC_suffix        = AX09
<!--Clinical data-->
| PubChem          = 65784
| tradename =
| ATC_supplemental  = {{ATC|M01|AX24}}
| Drugs.com = {{drugs.com|international|oxaceprol}}
| DrugBank          =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| C=7|H=11|N=1|O=4
| pregnancy_US = <!-- A / B            / C / D / X -->
| molecular_weight  = 172.159 g/mol
| pregnancy_category =   
| bioavailability  =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| protein_bound    =
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| metabolism        =
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| elimination_half-life =
| legal_US = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| excretion        =
| legal_status = 
| pregnancy_AU     = <!-- A / B1 / B2 / B3 / C / D / X -->
| routes_of_administration = 
| pregnancy_US     = <!-- A / B            / C / D / X -->
 
| pregnancy_category=   
<!--Pharmacokinetic data-->
| legal_AU         = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| bioavailability = 
| legal_CA         = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| protein_bound = 
| legal_UK         = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| metabolism = 
| legal_US         = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| elimination_half-life = 
| legal_status      =  
| excretion = 
| routes_of_administration =  
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 33996-33-7
| ATC_prefix = D11
| ATC_suffix = AX09
| ATC_supplemental =  {{ATC|M01|AX24}}
| PubChem = 65784
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = 
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = Q0XV76B96L
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07215
| ChemSpiderID     = 59203
| ChEMBL = 1407356
 
<!--Chemical data-->
| C=7 | H=11 | N=1 | O=4
| molecular_weight = 172.159 g/mol
| smiles            = CC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
| InChI            = 1/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
| InChIKey          = BAPRUDZDYCKSOQ-RITPCOANBI
| StdInChI          = 1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
| StdInChIKey      = BAPRUDZDYCKSOQ-RITPCOANSA-N
| synonyms = <small>(2''S'',4''R'')-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid</small>
}}
}}
__NOTOC__
{{SI}}
{{SI}}


{{CMG}}


==Overview==
==Overview==
'''Oxaceprol''' is an anti-inflammatory drug used in the treatment of [[osteoarthritis]].<ref name="pmid10791619">{{cite journal |author=Herrmann G, Steeger D, Klasser M, ''et al'' |title=Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac |journal=Clin. Rheumatol. |volume=19 |issue=2 |pages=99-104 |year=2000 |pmid=10791619 |doi=}}</ref>
'''Oxaceprol''' is an anti-inflammatory drug used in the treatment of [[osteoarthritis]].<ref name="pmid10791619">{{cite journal |author=Herrmann G |title=Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac |journal=Clin. Rheumatol. |volume=19 |issue=2 |pages=99–104 |year=2000 |pmid=10791619 |doi=10.1007/s100670050025 |author-separator=, |author2=Steeger D |author3=Klasser M |display-authors=3 |last4=Wirbitzky |first4=J. |last5=f&#x000Fc;Rst |first5=M. |last6=Venbrocks |first6=R. |last7=Rohde |first7=H. |last8=Jungmichel |first8=D. |last9=Hildebrandt |first9=H. D.}}</ref> It is derived from [[L-proline]], a DNA-encoded [[amino acid]]. The active effect of Oxaceprol is to inhibit the adhesion and migration of [[white blood cell]]s.<ref name="Clayton2007"/>


==References==
==References==
<references/>
{{reflist|refs=
<ref name="Clayton2007">{{Citation
| first1    = James J.
| last1    = Clayton
| title    = Nutraceuticals in the Management of Osteoarthritis
| journal  = Orthopedics
|date=August 2007
| volume    = 30
| issue    = 8
| url      = http://www.healio.com/orthopedics/journals/ORTHO/%7BD4DA9AAE-37CE-4E4A-9C5E-B518F4CFC952%7D/Nutraceuticals-in-the-Management-of-Osteoarthritis
| accessdate= 2013-06-08
| postscript= .
}}</ref>
}}
==References==
 
{{reflist|2}}
 


{{Other dermatological preparations}}
{{Other dermatological preparations}}
{{Anti-inflammatory and antirheumatic products}}
{{Anti-inflammatory and antirheumatic products}}


[[Category:Carboxylic acids]]
[[Category:Pyrrolidines]]
[[Category:Pyrrolidines]]
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{{WikiDoc Sources}}
[[Category:Alcohols]]
[[Category:Amino acid derivatives]]
[[Category:Drug]]

Revision as of 17:50, 8 April 2015

Oxaceprol
File:Oxaceprol.svg
Clinical data
Synonyms(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC7H11NO4
Molar mass172.159 g/mol
3D model (JSmol)
  (verify)


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.[1] It is derived from L-proline, a DNA-encoded amino acid. The active effect of Oxaceprol is to inhibit the adhesion and migration of white blood cells.[2]

References

  1. ↑ Herrmann G; Steeger D; Klasser M; et al. (2000). "Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac". Clin. Rheumatol. 19 (2): 99–104. doi:10.1007/s100670050025. PMID 10791619. Unknown parameter |author-separator= ignored (help)
  2. ↑ Clayton, James J. (August 2007), "Nutraceuticals in the Management of Osteoarthritis", Orthopedics, 30 (8), retrieved 2013-06-08.

References


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