Cortivazol: Difference between revisions

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{{drugbox |
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 447611525
| IUPAC_name = (11β,16α)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-''2'H''-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one
| IUPAC_name = (11β,16α)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-''2'H''-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one
| image = Cortivazol.png
| image = Cortivazol.png
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|cortivazol}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK = <!-- GSL        / P      / POM / CD -->
| legal_US = <!-- OTC                  / Rx-only  -->
| legal_status = 
| routes_of_administration = 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1110-40-3
| CAS_number = 1110-40-3
| ATC_prefix = H02
| ATC_prefix = H02
| ATC_suffix = AB17
| ATC_suffix = AB17
| PubChem = 66249
| PubChem = 66249
| DrugBank =  
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| C=32|H=38|N=2|O=5  
| ChEMBL = 2105842
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 59633
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = YM183K0H63
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D03594
 
<!--Chemical data-->
| C=32 | H=38 | N=2 | O=5  
| molecular_weight = 530.655
| molecular_weight = 530.655
| bioavailability =  
| smiles = O=C(OCC(=O)[C@@]4(O)[C@H](C)C[C@H]5[C@@H]6/C=C(\C3=C\c1c(cnn1c2ccccc2)C[C@@]3([C@H]6[C@@H](O)C[C@]45C)C)C)C
| protein_bound =  
| InChI = 1/C32H38N2O5/c1-18-11-23-25-12-19(2)32(38,28(37)17-39-20(3)35)31(25,5)15-27(36)29(23)30(4)14-21-16-33-34(26(21)13-24(18)30)22-9-7-6-8-10-22/h6-11,13,16,19,23,25,27,29,36,38H,12,14-15,17H2,1-5H3/t19-,23+,25+,27+,29-,30+,31+,32+/m1/s1
| metabolism =  
| InChIKey = RKHQGWMMUURILY-UHRZLXHJBR
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =  
| StdInChI = 1S/C32H38N2O5/c1-18-11-23-25-12-19(2)32(38,28(37)17-39-20(3)35)31(25,5)15-27(36)29(23)30(4)14-21-16-33-34(26(21)13-24(18)30)22-9-7-6-8-10-22/h6-11,13,16,19,23,25,27,29,36,38H,12,14-15,17H2,1-5H3/t19-,23+,25+,27+,29-,30+,31+,32+/m1/s1
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = RKHQGWMMUURILY-UHRZLXHJSA-N
| pregnancy_category =
| legal_AU =     <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US =      <!-- OTC                  / Rx-only  -->
| legal_status =  
| routes_of_administration =  
}}
}}


'''Cortivazol''' is a [[glucocorticoid]].
'''Cortivazol''' is a high-affinity [[agonist]] [[ligand (biochemistry)|ligand]] for the [[glucocorticoid receptor]] and consequently is classified as a [[glucocorticoid]].<ref name="pmid4029081">{{cite journal | author = Schlechte JA, Simons SS, Lewis DA, Thompson EB | title = [3H]cortivazol: a unique high affinity ligand for the glucocorticoid receptor | journal = Endocrinology | volume = 117 | issue = 4 | pages = 1355–62 |date=October 1985 | pmid = 4029081 | doi = 10.1210/endo-117-4-1355| url =  }}</ref>
 
It is sometimes abbreviated "CVZ".<ref name="pmid15677712">{{cite journal |author=Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H |title=The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor |journal=Mol. Endocrinol. |volume=19 |issue=5 |pages=1110–24 |date=May 2005 |pmid=15677712 |doi=10.1210/me.2004-0264 |url=http://mend.endojournals.org/cgi/pmidlookup?view=long&pmid=15677712}}</ref>
 
==References==
{{Reflist|2}}
 
==External links==
{{MeshName|Cortivazol}}
 


{{Glucocorticoids}}
{{Glucocorticoidics}}


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Revision as of 19:18, 8 April 2015

Cortivazol
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC32H38N2O5
Molar mass530.655
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Cortivazol is a high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid.[1]

It is sometimes abbreviated "CVZ".[2]

References

  1. ↑ Schlechte JA, Simons SS, Lewis DA, Thompson EB (October 1985). "[3H]cortivazol: a unique high affinity ligand for the glucocorticoid receptor". Endocrinology. 117 (4): 1355–62. doi:10.1210/endo-117-4-1355. PMID 4029081.
  2. ↑ Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H (May 2005). "The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor". Mol. Endocrinol. 19 (5): 1110–24. doi:10.1210/me.2004-0264. PMID 15677712.

External links

Cortivazol at the US National Library of Medicine Medical Subject Headings (MeSH)


Template:Glucocorticoids


Template:Systemic-hormonal-drug-stub

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