Tropisetron: Difference between revisions
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| IUPAC_name = [(1''S'',5''S'')-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 1''H''-indole-3-carboxylate | | IUPAC_name = [(1''S'',5''S'')-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 1''H''-indole-3-carboxylate | ||
| image =Tropisetron.png | | image =Tropisetron.png | ||
| image2 = | | image2 =Tropisetron3Dan.gif | ||
| width = 200px | | width = 200px | ||
| CAS_number = 89565-68-4 | | CAS_number = 89565-68-4 | ||
Revision as of 15:38, 10 April 2015
| File:Tropisetron.png | |
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| Clinical data | |
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| Routes of administration | Oral, IM |
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| Pharmacokinetic data | |
| Bioavailability | ~60–80% |
| Protein binding | 71% |
| Metabolism | Hepatic (CYP3A4, CYP1A2, CYP2D6) |
| Elimination half-life | 6–8 hours |
| Excretion | Renal, Fecal |
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| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C17H20N2O2 |
| Molar mass | 284.353 g/mol |
| 3D model (JSmol) | |
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Ongoing Trials on Tropisetron at Clinical Trials.gov Clinical Trials on Tropisetron at Google
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US National Guidelines Clearinghouse on Tropisetron
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Patient resources on Tropisetron Discussion groups on Tropisetron Patient Handouts on Tropisetron Directions to Hospitals Treating Tropisetron Risk calculators and risk factors for Tropisetron
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.[1] The drug is available in a 5 mg oral preparation or in 2 mg intravenous form. It is marketed by Novartis in Europe, Australia and New Zealand as Navoban, but is not available in the U.S.
Adverse effects
Tropisetron is a well-tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drug's use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system.
External links
References
- ↑ Muller, W. (2004). "Local treatment of tendinopathies and myofascial pain syndromes with the 5-HT3 receptor antagonist tropisetron". Scand J Rheumatic Suppl. 119: 44–48. PMID 15515413. Retrieved 2007-05-17. Unknown parameter
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- Antiemetics
- 5-HT3 antagonists
- Tropanes
- Drugs