Tyloxapol: Difference between revisions

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Tyloxapol
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R05CA01 (WHO) ;
Identifiers
	IUPAC name formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol;
CAS Number	25301-02-4 ;
PubChem CID	71388;
DrugBank	DB06439 ;
ChemSpider	11052515 ;
UNII	Y27PUL9H56;
KEGG	D03261 ;
ChEMBL	ChEMBL1201548 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	(C15H21O(C2H4O)m)n
Molar mass	variable
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Revision as of 18:23, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent^{[citation needed]} (containing mucus and pus) bronchopulmonary secretions,^[1]^[2] administered by inhalation through a nebulizer^[3] or with a stream of oxygen.

With intraperitoneal injection, tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. This mechanism is used to induce experimental hyperlipidemia in animals.^[4]

Tyloxapol is the main active ingredient of the medical device Tacholiquin. Tacholiquin is an Expectorant designated for inhalation and instillation reaching the upper and lower airways. Other brand names of pharmaceutical products containing Tyloxpol are: Exosurf, Alevaire

References

↑ PMID 8151722 (PMID 8151722)
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↑ PMID 1555424 (PMID 1555424)
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↑ Drugs.com: Tyloxapol definition
↑ PMID 12231215 (PMID 12231215)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

Template:Cough and cold preparations

[1] PMID 8151722 (PMID 8151722)
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[2] PMID 1555424 (PMID 1555424)
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[3] Drugs.com: Tyloxapol definition

[4] PMID 12231215 (PMID 12231215)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        =
+| Verifiedfields = changed
-| image             =
+| Watchedfields = changed
-| CAS_number        = 25301-02-4
+| verifiedrevid = 376126506
-| ATC_prefix        = R05
+| IUPAC_name = formaldehyde;oxirane;4-(2,4,4-trimethylpentan-2-yl)phenol
-| ATC_suffix        = CA01
+| image = Tyloxapol.png
-| PubChem           =
+| width = 150
-| DrugBank          =
-| chemical_formula  =
+<!--Clinical data-->
-| molecular_weight  =
+| tradename =
-| bioavailability   =
+| Drugs.com = {{drugs.com|international|tyloxapol}}
-| protein_bound     =
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| metabolism        =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| elimination_half-life =
+| pregnancy_category =
-| excretion         =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| pregnancy_category=
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| legal_status =
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| routes_of_administration =
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+<!--Pharmacokinetic data-->
-| legal_status      =
+| bioavailability =
-| routes_of_administration =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 25301-02-4
+| ATC_prefix = R05
+| ATC_suffix = CA01
+| PubChem = 71388
+| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
+| DrugBank = DB06439
+| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID = 11052515
+| UNII_Ref = {{fdacite|changed|FDA}}
+| UNII = Y27PUL9H56
+| KEGG_Ref = {{keggcite|changed|kegg}}
+| KEGG = D03261
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 1201548
+<!--Chemical data-->
+| chemical_formula = (C<sub>15</sub>H<sub>21</sub>O(C<sub>2</sub>H<sub>4</sub>O)<sub>m</sub>)<sub>n</sub>
+| molecular_weight = variable
 }}
-'''Tyloxapol''' is a nonionic liquid [[polymer]] of the alkyl aryl polyether alcohol type; used as a [[surfactant]] to aid [[liquefaction]] and removal of mucopurulent (containing [[mucus]] and [[pus]]) bronchopulmonary secretions, administered by inhalation through a [[nebulizer]] or with a stream of oxygen.
+__NOTOC__
-Tyloxapol, when injected IP, also blocks plasma lipolytic activity, and thus the breakdown of [[triglyceride]]-rich [[lipoproteins]].
-{{pharma-stub}}
+{{SI}}
+{{CMG}}
+==Overview==
+'''Tyloxapol''' is a nonionic liquid [[polymer]] of the alkyl aryl polyether alcohol type. It is used as a [[surfactant]] to aid [[liquefaction]] and removal of mucopurulent{{fact|date=December 2013}} (containing [[mucus]] and [[pus]]) bronchopulmonary secretions,<ref>{{cite pmid|8151722}}</ref><ref>{{cite pmid|1555424}}</ref> administered by inhalation through a [[nebulizer]]<ref>Drugs.com: [http://www.drugs.com/dict/tyloxapol.html Tyloxapol definition]</ref> or with a stream of oxygen.
+With [[intraperitoneal injection]], tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of [[triglyceride]]-rich [[lipoprotein]]s. This mechanism is used to induce experimental [[hyperlipidemia]] in animals.<ref>{{cite pmid|12231215}}</ref>
+Tyloxapol is the main active ingredient of the medical device Tacholiquin. Tacholiquin is an Expectorant designated for inhalation and instillation reaching the upper and lower airways.
+Other brand names of pharmaceutical products containing Tyloxpol are: Exosurf, Alevaire
+==References==
+{{reflist|2}}
 {{Cough and cold preparations}}
-[[pl:Tyloksapol]]
 [[Category:Expectorants]]
+[[Category:Phenol ethers]]
+[[Category:Drug]]

Tyloxapol: Difference between revisions

Revision as of 18:23, 10 April 2015

Overview

References

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