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{{drugbox |
{{Drugbox
| IUPAC_name = ''1-[1-[4-(4-fluorophenyl)-4-oxo-butyl] -4-piperidyl]-3H-benzoimidazol-2-one''
| Verifiedfields = changed
| image = Benperidol.png  
| verifiedrevid = 459533587
| IUPAC_name = 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2''H''-benzimidazol-2-one
| image = Benperidol.png
| width = 250
| width = 250
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|benperidol}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK = <!-- GSL        / P      / POM / CD -->
| legal_US = Rx-only
| legal_status = 
| routes_of_administration = Oral
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|??}}
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 983-42-6
| CAS_number = 983-42-6
| ATC_prefix = N05
| ATC_prefix = N05
| ATC_suffix = AD07  
| ATC_suffix = AD07
| PubChem = 16363
| PubChem = 16363
| DrugBank =  
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 15521
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 97O6X78C53
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 297302
 
<!--Chemical data-->
| C=22 | H=24 | F=1 | N=3 | O=2  
| C=22 | H=24 | F=1 | N=3 | O=2  
| molecular_weight = 381.443g/mol
| molecular_weight = 381.443 g/mol
| bioavailability =  
| smiles = Fc1ccc(cc1)C(=O)CCCN4CCC(N3c2ccccc2NC3=O)CC4
| protein_bound =  
| InChI = 1/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
| metabolism =  
| InChIKey = FEBOTPHFXYHVPL-UHFFFAOYAW
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =
| StdInChI = 1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = FEBOTPHFXYHVPL-UHFFFAOYSA-N
| pregnancy_category = 
| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_UK =      <!-- GSL        / P      / POM / CD -->
| legal_US = Rx-only
| legal_status =
| routes_of_administration = Oral
}}
}}
'''Benperidol''' is a drug which is a highly potent [[butyrophenone]] derivative. It is in fact the most potent neuroleptic on the european market, with [[chlorpromazine]] equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to [[haloperidol]]).<ref>Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)</ref>. It is an [[antipsychotic]], which can be used for the treatment of [[schizophrenia]]<ref> Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.</ref>, but it is primarily used to control deviant, [[antisocial]] [[hypersexual]] behaviour<ref>British National Formulary (49th), British Medical Association 2005 p 183</ref>, and is sometimes prescribed to [[sex offender]]s as a condition of their [[parole]], as an alternative to anti-[[androgen]] drugs such as [[cyproterone]].<ref>Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.</ref>
__NOTOC__


Benperidol was discovered at [[Janssen Pharmaceutica]] in [[1961]].
{{SI}}


== References ==
{{CMG}}
{{reflist|2}}


==Overview==
'''Benperidol''' is a drug which is a highly potent [[butyrophenone]] derivative. It is the most potent neuroleptic on the European market, with [[chlorpromazine]] equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to [[haloperidol]]).<ref>Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)</ref> It is an [[antipsychotic]], which can be used for the treatment of [[schizophrenia]],<ref>Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.</ref> but it is primarily used to control [[Anti-social behaviour|antisocial]] [[hypersexual]] behaviour,<ref>British National Formulary (49th), British Medical Association 2005 p 183</ref> and is sometimes prescribed to [[sex offender]]s as a condition of their [[parole]], as an alternative to anti-[[androgen]] drugs such as [[cyproterone acetate]].<ref>Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.</ref>


[[Category:Antipsychotics]]
Benperidol was discovered at [[Janssen Pharmaceutica]] in 1961.


== References ==
{{Reflist|2}}


{{Antipsychotics}}
{{Antipsychotics}}
{{Dopaminergics}}


{{pharm-stub}}
[[Category:Piperidines]]
 
[[Category:Organofluorides]]
[[de:Benperidol]]
[[Category:Benzimidazoles]]
[[ru:Бенперидол]]
[[Category:Butyrophenone antipsychotics]]
{{WikiDoc Sources}}
[[Category:Janssen Pharmaceutica]]
[[Category:Belgian inventions]]
[[Category:Drug]]

Revision as of 16:24, 13 April 2015

Benperidol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC22H24FN3O2
Molar mass381.443 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Benperidol is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1] It is an antipsychotic, which can be used for the treatment of schizophrenia,[2] but it is primarily used to control antisocial hypersexual behaviour,[3] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[4]

Benperidol was discovered at Janssen Pharmaceutica in 1961.

References

  1. ↑ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
  2. ↑ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
  3. ↑ British National Formulary (49th), British Medical Association 2005 p 183
  4. ↑ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
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