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| | melting_high = 92 | | | melting_high = 92 |
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| '''Chlorphenesin''' ('''Maolate''', '''Musil''') is a centrally acting [[muscle relaxant]] used to treat muscle pain and [[spasm]]s.<ref>{{cite journal | last1 = Okuyama | first1 = S | last2 = Aihara | first2 = H | title = Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats | journal = Research communications in chemical pathology and pharmacology | volume = 55 | issue = 2 | pages = 147–60 | year = 1987 | pmid = 3823606 }}</ref><ref>{{cite journal | last1 = Kurachi | first1 = M | last2 = Aihara | first2 = H | title = Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats | journal = Japanese journal of pharmacology | volume = 36 | issue = 1 | pages = 7–13 | year = 1984 | pmid = 6503049 | doi = 10.1254/jjp.36.7 }}</ref> Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as [[benzodiazepines]].
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| Other central effects include sedation, [[anxiolytic|anxiolysis]], and dizziness. It also has [[Antifungal medication|antifungal]] and some [[antibacterial]] properties and is thus classified as an antifungal for topical use by the WHO.<ref>[http://www.whocc.no/atc_ddd_index/?code=D01AE07 ATC code D01AE07]</ref>
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| ==Safety==
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| The major adverse effect from this preservative on skin is [[allergy|allergic contact sensitivity]].<ref>{{cite journal |doi=10.1111/j.1600-0536.1981.tb04601.x |journal=Contact Dermatitis |year=1981 |volume=7 |issue=3 |pages=162 |title=Chlorphenesin sensitivity |author=Brown R |pmid=6456118}}</ref><ref>{{cite journal |doi=10.1111/j.1600-0536.1986.tb01234.x |journal=Contact Dermatitis |year=1986 |volume=14 |issue=33 |pages=246 |title=Allergic contact sensitivity to chlorphenesin |author=Burns DA |pmid=2941223 }}</ref> Systemic intoxication from [[transdermal]] use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.<ref>{{Cite web| url=http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116900.htm}}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Antifungals}}
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| {{Muscle relaxants}}
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| [[Category:Muscle relaxants]]
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| [[Category:Carbamates]]
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| [[Category:Alcohols]]
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| [[Category:Phenol ethers]]
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| [[Category:Organochlorides]]
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