Quinupramine: Difference between revisions

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Quinupramine
Clinical data
Routes of; administration	Oral
ATC code	N06AA23 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	33 hours
Identifiers
	IUPAC name (±)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine;
CAS Number	31721-17-2;
PubChem CID	93154;
ChemSpider	84098;
UNII	29O61HFF4L;
KEGG	D07336;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H24N2
Molar mass	304.43 g/mol

Newer edit →

VisualWikitext

Revision as of 12:26, 14 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Quinupramine (Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression.^[1]^[2]

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H₁ receptor antagonist (antihistamine), moderate 5-HT₂ receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor.^[3] It has negligible affinity for the α₁-adrenergic, α₂-adrenergic, β-adrenergic, or D₂ receptor.^[3]

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline.^[4] It can be inferred that its in vivo metabolites may have stronger effects on the reuptake of norepinephrine and/or serotonin than quinupramine itself.^{[citation needed]}

References

↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 908. ISBN 3-88763-075-0.
↑ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 248. ISBN 3-527-31058-4.
↑ ^3.0 ^3.1 Sakamoto H, Yokoyama N, Kohno S, Ohata K (December 1984). "Receptor binding profile of quinupramine, a new tricyclic antidepressant". Japanese Journal of Pharmacology. 36 (4): 455–60. doi:10.1254/jjp.36.455. PMID 6098759.
↑ Kent, Angela; M. Billiard (2003). Sleep: physiology, investigations, and medicine. New York: Kluwer Academic/Plenum. p. 233. ISBN 0-306-47406-9.

Template:Antidepressants

[isbn3-88763-075-0-1] Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 908. ISBN 3-88763-075-0.

[isbn3-527-31058-4-2] José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 248. ISBN 3-527-31058-4.

[pmid6098759-3] 3.0 ^3.1 Sakamoto H, Yokoyama N, Kohno S, Ohata K (December 1984). "Receptor binding profile of quinupramine, a new tricyclic antidepressant". Japanese Journal of Pharmacology. 36 (4): 455–60. doi:10.1254/jjp.36.455. PMID 6098759.

[isbn0-306-47406-9-4] Kent, Angela; M. Billiard (2003). Sleep: physiology, investigations, and medicine. New York: Kluwer Academic/Plenum. p. 233. ISBN 0-306-47406-9.

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@@ Line 45: / Line 45: @@
 {{Antidepressants}}
-{{Adrenergics}}
-{{Cholinergics}}
-{{Histaminergics}}
-{{Serotonergics}}
-{{Tricyclics}}
 [[Category:Tricyclic antidepressants]]
-[[Category:Quinuclidines]]
-[[Category:Dibenzazepines]]
 [[Category:Drug]]
-{{nervous-system-drug-stub}}

Clinical data

Routes of administration	Oral
ATC code	N06AA23 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life	33 hours
Identifiers
IUPAC name (±)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine
CAS Number	31721-17-2
PubChem CID	93154
ChemSpider	84098
UNII	29O61HFF4L
KEGG	D07336
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₁H₂₄N₂
Molar mass	304.43 g/mol

Quinupramine: Difference between revisions

Revision as of 12:26, 14 April 2015

Overview

References

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