Tricaine mesilate: Difference between revisions

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Tricaine mesilate
Clinical data
Synonyms	Metacaine; Tricaine; MS-222; Finquel; TMS
ATCvet code	Template:Infobox drug/formatATCvet; Template:Infobox drug/formatATCvet;
Identifiers
	IUPAC name Ethyl 3-aminobenzoate methanesulfonic acid;
CAS Number	886-86-2 ;
PubChem CID	13454;
ChemSpider	12878 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H15NO5S
Molar mass	261.296 g/mol
3D model (JSmol)	Interactive image;
Melting point	149.5 °C (301.1 °F)
	SMILES [NH3+]C1=CC=CC(C(OCC)=O)=C1.CS(=O)([O-])=O;
	InChI InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4) ; Key:FQZJYWMRQDKBQN-UHFFFAOYSA-N ;
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VisualWikitext

Revision as of 15:17, 14 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tricaine mesylate (Tricaine methanesulfonate, TMS, MS-222), is white powder used for anesthesia, sedation, or euthanasia of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption. The drug can have selective toxicity for poikilotherms due to their lower rate of metabolism in the liver.^[1]

TMS is a muscle relaxant that operates by preventing action potentials.^{[citation needed]}By blocking action potentials, no signals can be exchanged between the brain and the extremities. There will be no sensory input or muscle contractions which would have been caused by action potential, which includes most muscles.

The optimum concentration may vary with the size and species of the fish, and other variables.

It is easily soluble in water (both fresh and salt) but it drastically decreases the pH of water, increasing the acidity, which may be toxic for fish. Sodium bicarbonate can be used to buffer the solution to a pH range of 6.5-7.5. Usually an equal amount of buffer is added to attain a neutral pH.^[2] In salt/marine/sea water, the buffer use may not be necessary because sea water itself has buffering capacity.

The solution of TMS needs to be prepared freshly each time because TMS is light-sensitive and might form toxic by-products upon exposure to light.

References

↑ Wayson KA(1976)."Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selectivity toxicity in poikilotherms."J Pharmacol Exp Ther198(3):695-708. [PMID 185356]
↑ http://www.research.cornell.edu/care/documents/ACUPs/ACUP306.pdf

[1] Wayson KA(1976)."Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selectivity toxicity in poikilotherms."J Pharmacol Exp Ther198(3):695-708. [PMID 185356]

[2] ttp://www.research.cornell.edu/care/documents/ACUPs/ACUP306.pdf

[1]

[2]

@@ Line 53: / Line 53: @@
 | melting_point = 149.5
 }}
+                     __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Tricaine mesylate''' ('''Tricaine methanesulfonate''', '''TMS''', '''MS-222'''), is white powder used for [[anesthesia]], sedation, or [[euthanasia]] of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption.
@@ Line 66: / Line 70: @@
 ==References==
-<references/>
+                   {{Reflist|2}}
-{{DEFAULTSORT:Tricaine Mesylate}}
-[[Category:General anesthetics]]
+[[Category:Drug]]
 [[Category:Benzoates]]

Clinical data

Synonyms	Metacaine Tricaine MS-222 Finquel TMS
ATCvet code	Template:Infobox drug/formatATCvet Template:Infobox drug/formatATCvet
Identifiers
IUPAC name Ethyl 3-aminobenzoate methanesulfonic acid
CAS Number	886-86-2^Y
PubChem CID	13454
ChemSpider	12878^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₀H₁₅NO₅S
Molar mass	261.296 g/mol
3D model (JSmol)	Interactive image
Melting point	149.5 °C (301.1 °F)
SMILES [NH3+]C1=CC=CC(C(OCC)=O)=C1.CS(=O)([O-])=O
InChI InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)^N Key:FQZJYWMRQDKBQN-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Tricaine mesilate: Difference between revisions

Revision as of 15:17, 14 April 2015

Overview

References

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