Tiazofurine: Difference between revisions

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Tiazofurine
Clinical data
Synonyms	2-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
ATC code	L01XX18 (WHO) ;
Identifiers
	IUPAC name (1R)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-D-ribitol;
CAS Number	60084-10-8;
PubChem CID	457954;
ChemSpider	403014 ;
UNII	ULJ82834RE;
ChEMBL	ChEMBL108358 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C9H12N2O5S
Molar mass	260.268 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(c1nc(sc1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N;
	InChI InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1 ; Key:FVRDYQYEVDDKCR-DBRKOABJSA-N ;
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Revision as of 16:44, 14 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tiazofurin is an inhibitor of IMP dehydrogenase. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer.^[1]

References

↑ Popsavin M, Torović L, Svircev M; et al. (2006). "Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities". Bioorg. Med. Chem. Lett. 16 (10): 2773–6. doi:10.1016/j.bmcl.2006.02.001. PMID 16495053.

[1] Popsavin M, Torović L, Svircev M; et al. (2006). "Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities". Bioorg. Med. Chem. Lett. 16 (10): 2773–6. doi:10.1016/j.bmcl.2006.02.001. PMID 16495053.

[1]

@@ Line 3: / Line 3: @@
 | verifiedrevid = 444227977
 | IUPAC_name = (1''R'')-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-<small>D</small>-ribitol
-| image = Tiazofurin.svg
+| image = Tiazofurin.png
 <!--Clinical data-->
@@ Line 53: / Line 53: @@
 | synonyms = 2-[(2''R'',3''R'',4''S'',5''R'')-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
 }}
-<!-- MeSHName=Tiazofurin -->
+<!-- MeSHName=Tiazofurin -->__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Tiazofurin''' is an [[enzyme inhibitor|inhibitor]] of [[IMP dehydrogenase]]. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer.<ref>{{cite journal |author=Popsavin M, Torović L, Svircev M et al. |title=Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities |journal=Bioorg. Med. Chem. Lett. |volume=16 |issue=10 |pages=2773–6 |year=2006 |pmid=16495053 |doi=10.1016/j.bmcl.2006.02.001}}</ref>
 ==References==
-{{reflist}}
+{{reflist|2}}
-{{Intracellular chemotherapeutic agents}}
 [[Category:Amides]]
-[[Category:Ribosides]]
+[[Category:Drug]]
 [[Category:Thiazoles]]
-[[Category:Experimental cancer drugs]]
-{{antineoplastic-drug-stub}}

Tiazofurine: Difference between revisions

Revision as of 16:44, 14 April 2015

Overview

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