Sandbox brain abscess: Difference between revisions
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==Antimicrobial Therapy – Empiric Therapy== | ==Antimicrobial Therapy – Empiric Therapy== | ||
{{rx|Preferred regimen}} | {{rx|Preferred regimen}} | ||
<li>[[Cefotaxime]] 8–12 g/day q4–6h | <li>[[Cefotaxime]] 8–12 g/day q4–6h {{or}} [[Ceftriaxone]] 4 g/day q12h {{and}} </li> | ||
<li>[[Metronidazole]] 30 mg/kg/day q6h</li> | <li>[[Metronidazole]] 30 mg/kg/day q6h</li> | ||
</ul> | </ul> | ||
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</ul> | </ul> | ||
{{rx|Transplant recipients}} | {{rx|Transplant recipients}} | ||
<li>[[Cefotaxime]] 8–12 g/day q4–6h | <li>[[Cefotaxime]] 8–12 g/day q4–6h {{or}} [[Ceftriaxone]] 4 g/day q12h {{and}} </li> | ||
<li>[[Metronidazole]] 30 mg/kg/day q6h {{and}} </li> | <li>[[Metronidazole]] 30 mg/kg/day q6h {{and}} </li> | ||
<li>[[Voriconazole]] 8 mg/kg/day q12h {{and}} </li> | <li>[[Voriconazole]] 8 mg/kg/day q12h {{and}} </li> | ||
<li>[[TMP-SMZ]] 10–20 mg/kg/day q6–12h | <li>[[TMP-SMZ]] 10–20 mg/kg/day q6–12h {{or}} [[Sulfadiazine]] 4–6 g/day q6h</li> | ||
</ul> | </ul> | ||
{{rx|Patients with HIV/AIDS}} | {{rx|Patients with HIV/AIDS}} | ||
<li>[[Cefotaxime]] 8–12 g/day q4–6h | <li>[[Cefotaxime]] 8–12 g/day q4–6h {{or}} [[Ceftriaxone]] 4 g/day q12h {{and}} </li> | ||
<li>[[Sulfadiazine]] 4–6 g/day q6h {{and}} </li> | <li>[[Sulfadiazine]] 4–6 g/day q6h {{and}} </li> | ||
<li>[[Pyrimethamine]] 25–100 mg/day qd</li> | <li>[[Pyrimethamine]] 25–100 mg/day qd</li> | ||
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</ul> | </ul> | ||
{{rx|Enterobacteriaceae}} | {{rx|Enterobacteriaceae}} | ||
<li>[[Cefotaxime]] 8–12 g/day q4–6h | <li>[[Cefotaxime]] 8–12 g/day q4–6h {{or}} [[Ceftriaxone]] 4 g/day q12h</li> | ||
</ul> | </ul> | ||
{{rx|Fusobacterium}} | {{rx|Fusobacterium}} | ||
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</ul> | </ul> | ||
{{rx|Haemophilus}} | {{rx|Haemophilus}} | ||
<li>[[Cefotaxime]] 8–12 g/day q4–6h | <li>[[Cefotaxime]] 8–12 g/day q4–6h {{or}} [[Ceftriaxone]] 4 g/day q12h</li> | ||
</ul> | </ul> | ||
{{rx|Listeria monocytogenes}} | {{rx|Listeria monocytogenes}} | ||
<li>[[Ampicillin]] 12 g/day q4h | <li>[[Ampicillin]] 12 g/day q4h {{or}} [[Penicillin G]] 24 MU q4h</li> | ||
</ul> | </ul> | ||
{{rx|Nocardia}} | {{rx|Nocardia}} | ||
<li>[[TMP-SMZ]] 10–20 mg/kg/day q6–12h | <li>[[TMP-SMZ]] 10–20 mg/kg/day q6–12h {{or}} [[Sulfadiazine]] 4–6 g/day q6h</li> | ||
</ul> | </ul> | ||
{{rx|Prevotella melaninogenica}} | {{rx|Prevotella melaninogenica}} | ||
| Line 61: | Line 61: | ||
</ul> | </ul> | ||
{{rx|Pseudomonas aeruginosa}} | {{rx|Pseudomonas aeruginosa}} | ||
<li>[[Ceftazidime]] 6 g/day q8h | <li>[[Ceftazidime]] 6 g/day q8h {{or}} [[Cefepime]] 6 g/day q8h</li> | ||
</ul> | </ul> | ||
{{rx|Methicillin-sensitive Staphylococcus aureus}} | {{rx|Methicillin-sensitive Staphylococcus aureus}} | ||
<li>[[Nafcillin]] 12 g/day q4h | <li>[[Nafcillin]] 12 g/day q4h {{or}} [[Oxacillin]] 12 g/day q4h</li> | ||
</ul> | </ul> | ||
{{rx|Methicillin-resistant Staphylococcus aureus}} | {{rx|Methicillin-resistant Staphylococcus aureus}} | ||
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</ul> | </ul> | ||
{{rx|Candida}} | {{rx|Candida}} | ||
<li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h | <li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h {{or}} [[Amphotericin B]] deoxycholate 15 mg/kg/day q8h</li> | ||
</ul> | </ul> | ||
{{rx|Cryptococcus neoformans}} | {{rx|Cryptococcus neoformans}} | ||
<li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h | <li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h {{or}} [[Amphotericin B]] deoxycholate 15 mg/kg/day q8h</li> | ||
</ul> | </ul> | ||
{{rx|Mucorales}} | {{rx|Mucorales}} | ||
<li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h | <li>[[Amphotericin B]] lipid complex 5 mg/kd/day q24h {{or}} [[Amphotericin B]] deoxycholate 15 mg/kg/day q8h</li> | ||
</ul> | </ul> | ||
{{rx|Pseudallescheria boydii (Scedosporium apiospermum)}} | {{rx|Pseudallescheria boydii (Scedosporium apiospermum)}} | ||
Revision as of 02:11, 19 April 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Brain abscess Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Sandbox brain abscess On the Web |
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American Roentgen Ray Society Images of Sandbox brain abscess |
Overview
Treatment of brain abscess requires a multidisciplinary approach to delineate extent of infection, plan stereotactic trajectory, aspirate purulent materials, lower intracranial pressure, identify causative pathogen, and administer appropriate antibiotics.