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| __NOTOC__
| | #REDIRECT [[Atovaquone-Proguanil]] |
| {{Atovaquone proguanil}}
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| {{CMG}}; {{AE}} {{chetan}}
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| ==Overview==
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| '''Atovaquone''' (alternative spelling: '''atavaquone''') is a chemical compound that belongs to the class of [[naphthoquinone]]s. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of [[ubiquinone]], with antipneumocystic activity. It is manufactured in the US in the liquid form, or oral suspension, under the brand name Malarone.
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| ==Category==
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| Antimalarial
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| ==US Brand Names==
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| MALARONE<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[Atovaquone proguanil description|Description]]'''
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| '''| [[Atovaquone proguanil clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Atovaquone proguanil microbiology|Microbiology]]'''
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| '''| [[Atovaquone proguanil indications and usage|Indications and Usage]]'''
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| '''| [[Atovaquone proguanil contraindications|Contraindications]]'''
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| '''| [[Atovaquone proguanil warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Atovaquone proguanil adverse reactions|Adverse Reactions]]'''
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| '''| [[Atovaquone proguanil drug interactions|Drug Interactions]]'''
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| '''| [[Atovaquone proguanil overdosage|Overdosage]]'''
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| '''| [[Atovaquone proguanil clinical studies|Clinical Studies]]'''
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| '''| [[Atovaquone proguanil dosage and administration|Dosage and Administration]]'''
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| '''| [[Atovaquone proguanil how supplied|How Supplied]]'''
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| '''| [[Atovaquone proguanil labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Atovaquone selectively inhibits the parasitic [[electron transport chain]].
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| Proguanil, via its metabolite [[cycloguanil]], functions as a [[dihydrofolate reductase inhibitor]], halting parasitic [[Thymidine|deoxythymidilate]] synthesis.<ref>http://us.gsk.com/products/assets/us_malarone.pdf</ref> | |
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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