Cetylpyridinium chloride: Difference between revisions

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| IUPACName = 1-Hexadecylpyridinium chloride
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|   CASNo = 123-03-5
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|   SMILES = CCCCCCCCCCCCCCCC[n+]1ccccc1.[Cl-]
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|   Formula = C<sub>21</sub>H<sub>38</sub>NCl
 
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'''Cetylpyridinium chloride''' ('''CPC''') is a [[cationic]] [[quaternary ammonium]] compound in some types of [[mouthwash]]es, [[toothpaste]]s, [[lozenge]]s, throat sprays, anti-snore throat sprays, breath sprays, and nasal sprays. It is an [[antiseptic]] that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental [[Dental plaque|plaque]] and reducing [[gingivitis]]. It has also been used  as an ingredient in certain [[pesticide]]s. However, this ingredient has also been shown (according to WebMD,<ref name="uslc-1">{{cite web|title=Tooth Discoloration: Causes and Treatments|url=http://www.webmd.com/content/article/66/79599.htm}}</ref> eMedicine,<ref name="uslc-2">{{cite web|title=Tooth Discoloration : Article by Jonathan A Ship, DMD|url=http://www.emedicine.com/derm/topic646.htm}}</ref> and Amazon.com<ref name="amazon">{{cite web|title=Amazon Product Page|url=http://www.amazon.com/gp/product/customer-reviews/B000BS6VWC/ref=cm_cr_dp_2_1/102-5647531-6773768?ie=UTF8&customer-reviews.sort%5Fby=-SubmissionDate&n=3760901}}</ref> and Drugstore.com reviews of Crest Pro-Health® rinse product) to cause brown stains between the teeth.


==Synonyms==
Cetylpyridinium chloride is called or is present in commercial products such as n as 1-palmitylpyridinium chloride, C16-alkylpyridinium chloride, 1-hexadecylpyridinium chloride, acetoquat CPC, aktivex, ammonyx CPC, cecure, ceepryn chloride, cepacol, ceprim, cepacol chloride, cetafilm, cetamium, dobendan, halset, ipanol, medilave, mercocet, merothol, pionin B, pristacin, pyrisept and asept.


==Physical and chemical properties==
<!--Label Display Image-->
Cetylpyridinium chloride has the molecular formula C<sub>21</sub>H<sub>38</sub>NCl and at its pure form is in a solid state at [[room temperature]]. It has a melting point of 77 °C when [[anhydrous]] or 80–83 °C in its [[monohydrate]] form. It is insoluble in [[acetone]], [[acetic acid]], or [[ethanol]]. It has a [[pyridine]]-like odor. It is combustible. Concentrated solutions are destructive to [[mucous membrane]]s. It is very toxic when inhaled.


The CAS number for the monohydrate is {{CASREF|CAS=6004-24-6}}.


In some products, '''cetylpyridinium bromide''' is used instead. Its properties are virtually identical.


==Toxicology and Pharmacology==
The [[LD50]] in rats is 200 mg/kg.


==References==
<div class="references-small">
<references/>
</div>


==External links==
<!--Category-->
* [http://physchem.ox.ac.uk/MSDS/CE/cetylpyridinium_chloride.html Material Safety Data Sheet]
* [http://www.cas.astate.edu/draganjac/cetylpyridiniumchloride.html Page on its use in mouthwash]
* [http://www.chemicalland21.com/lifescience/phar/CETYLPYRIDINIUM%20CHLORIDE.htm Chemical Information]
* [http://www.nature.com/bdj/journal/v194/n4/full/4809913a.html ''An in vitro evaluation of the availability of cetylpyridinium chloride and chlorhexidine in some commercially available mouthrinse products'' by S. Sheen and M. Addy in ''British Dental Journal'']


{{Throat preparations}}
[[Category:Drug]]
[[Category:Quaternary ammonium compounds]]
[[Category:Antiseptics]]
<br>
[[es:cloruro de cetilpiridinio]]
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Revision as of 12:49, 21 April 2015

Cetylpyridinium chloride
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Cetylpyridinium chloride is a {{{drugClass}}} that is FDA approved for the treatment of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Cetylpyridinium chloride in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Cetylpyridinium chloride in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Cetylpyridinium chloride in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Cetylpyridinium chloride in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Cetylpyridinium chloride in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Cetylpyridinium chloride in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Cetylpyridinium chloride in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Cetylpyridinium chloride in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Cetylpyridinium chloride during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Cetylpyridinium chloride with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Cetylpyridinium chloride with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Cetylpyridinium chloride with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Cetylpyridinium chloride with respect to specific gender populations.

Race

There is no FDA guidance on the use of Cetylpyridinium chloride with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Cetylpyridinium chloride in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Cetylpyridinium chloride in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Cetylpyridinium chloride in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Cetylpyridinium chloride in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Cetylpyridinium chloride in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Cetylpyridinium chloride in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Cetylpyridinium chloride in the drug label.

Pharmacology

There is limited information regarding Cetylpyridinium chloride Pharmacology in the drug label.

Mechanism of Action

Structure

File:Cetylpyridinium chloride01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Cetylpyridinium chloride in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Cetylpyridinium chloride in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Cetylpyridinium chloride in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Cetylpyridinium chloride in the drug label.

How Supplied

Storage

There is limited information regarding Cetylpyridinium chloride Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Cetylpyridinium chloride in the drug label.

Precautions with Alcohol

  • Alcohol-Cetylpyridinium chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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