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| {{drugbox |
| | #REDIRECT[[Ergonovine]] |
| | IUPAC_name = 9,10-didehydro-N-[1-(hydroxymethyl)-propyl]-D-lysergamide
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| | image = Methylergonovine.gif
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| | width = 140
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| | CAS_number = 113-42-8
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| | ATC_prefix =
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| | ATC_suffix =
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| | PubChem = 8226
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| | C=20 | H=25 | N=3 | O=2
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| | molecular_weight = 339.432 g/mol
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| | synonyms = Methylergonovine
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| | smiles = CC[C@@H](CO)NC(=O)[C@@H]2/C=C1/c3cccc4N\C=C(\C[C@H]1N(C)C2)c34
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| | melting_point = 172
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| | melting_high =
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| | pregnancy_AU =
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| | pregnancy_US =
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| | pregnancy_category =
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| | legal_AU =
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| | legal_CA =
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| | legal_UK =
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| | legal_US =
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| | legal_status = Prescription Only Medicine
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| | routes_of_administration =
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| }}
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| '''Methylergonovine''', also known as [[methylergometrine]], [[methylergobasin]], and d-[[lysergic acid]] 1-[[butanol]][[amide]], is a [[chemical synthesis|synthetic]] [[analog (chemistry)|analogue]] of [[ergonovine]], a [[psychedelic]] [[alkaloid]] found in [[ergot]], and many species of [[morning glory]]. It is a member of the [[ergoline]] family and chemically similar to [[LSD]], [[ergine]], [[ergonovine]], and [[lysergic acid]]. Due to its [[oxytocic]] properties, it has a medical use in [[obstetrics]]. According to [[Jonathan Ott]], methylergonovine has [[LSD]]-like actions above 2 milligrams. Clinical dosages are ten times lower.
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| ==Obstetric Use==
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| Methergine (methylergonovine maleate) is a blood vessel constrictor and smooth muscle agonist most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion. It also causes uterine contractions to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth. It is available as tablets or injection ([[intramuscular injection|IM]] or [[intravenous therapy|IV]]) or in liquid form to be taken orally.
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| ==Side Effects==
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| * [[cholinergic]] effects such as nausea, vomiting, and diarrhea
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| * cramping
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| * dizziness.
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| ==Contraindications==
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| * [[hypertension]]
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| * pregnancy
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| {{Hallucinogenic lysergamides}}
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| [[Category:Lysergamides]] | |
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| {{hallucinogen-stub}}
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| {{WikiDoc Sources}}
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