Toxic epidermal necrolysis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, nonsteroidal anti-inflammatory drugs, allopurinol, antiretroviral drugs, corticosteroids and anticonvulsants such as phenobarbital, phenytoin, carbamazepine, and valproic acid. The condition might also result from immunizations, infection with agents such as Mycoplasma pneumoniae or herpes virus and transplants of bone marrow or organs.

Causes

Drug Side Effects

• Acetaminophen
• Amifostine
• Amoxycillin
• Aztreonam
• Butalbital
• Cefadroxil
• Cefaclor
• Ceftibuten
• Cefotaxime sodium
• Cefotetan disodium
• Ceftazidime
• Certolizumab pegol
• Cladribine
• Clobazam
• clofarabine
• Cysteamine
• Cytarabine
• Dactinomycin
• diclofenac (patch)
• Doripenem
• Etravirine
• Flurbiprofen
• Idelalisib
• Piperacillin/tazobactam
• Pralatrexate
• Lacosamide
• Rifampin
• Ritonavir
• Ibritumomab tiuxetan
• Isotretinoin
• Meropenem
• Oxaprozin
• Terconazole
• [[Tolmetin
• Piperacillin
• Sorafenib
• Spironolactone
• Sulfasalazine
• Sulfacetamide
• Trovafloxacin mesylate

• Valdecoxib,

References

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