Sandbox Organ-Based Infections: Difference between revisions
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====Osteomyelitis, Contiguous without vascular insufficiency==== | ====Osteomyelitis, Contiguous without vascular insufficiency==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[ | * '''[[Vancomycin]]''' 1 gm IV q12h {{and}} | ||
* '''[[ | * '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h | ||
</li> | </li> | ||
{{Rx|Alternative Regimen}} | {{Rx|Alternative Regimen}} | ||
* '''[[ | * '''[[Linezolid]]''' 600 mg po/IV bid {{and}} | ||
* '''[[ | * '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h | ||
</li> | |||
{{Rx|If susceptible Gram-negative bacilli are isolated}} | |||
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Linezolid]]''' 600 mg po/IV bid | |||
</li> | |||
{{Rx|If methicillin-sensitive staphylococci are isolated}} | |||
* '''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h {{or}} '''[[Cefazolin]]''' 2 gm IV q8h | |||
</li> | |||
{{Rx|If methicillin-resistant staphylococci are isolated}} | |||
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L | |||
</li> | </li> | ||
Revision as of 07:47, 9 May 2015
Musculoskeletal
Osteomyelitis
Osteomyelitis, Candidal osteomyelitis
- Fluconazole 400 mg (6 mg/kg) IV/po daily OR Lipid-based Amphotericin B 3-5 mg/kg daily for two weeks, followed by Fluconazole
- Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
Osteomyelitis, Chronic osteomyelitis
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement
Osteomyelitis, Contiguous with vascular insufficiency
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement AND
- Revascularization if possible
Osteomyelitis, Contiguous without vascular insufficiency
- Vancomycin 1 gm IV q12h AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Linezolid 600 mg po/IV bid AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Ciprofloxacin 750 mg po bid OR Linezolid 600 mg po/IV bid
- Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L