Lorazepam (oral)

Lorazepam (oral)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

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Overview

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Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

• Lorazepam is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

• The effectiveness of lorazepam in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.

Dosage

• Lorazepam is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available.

• The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

• For anxiety, most patients require an initial dose of 2 to 3 mg/day given b.i.d. or t.i.d.

• For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given, usually at bedtime.

• For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated.

• The dosage of lorazepam should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Lorazepam (oral) in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Lorazepam (oral) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Lorazepam (oral) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Lorazepam (oral) in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Lorazepam (oral) in pediatric patients.

Contraindications

There is limited information regarding Lorazepam (oral) Contraindications in the drug label.

Warnings

There is limited information regarding Lorazepam (oral) Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Lorazepam (oral) in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Lorazepam (oral) in the drug label.

Drug Interactions

There is limited information regarding Lorazepam (oral) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

• Pregnancy Category

Pregnancy Category (AUS):

• Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Lorazepam (oral) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Lorazepam (oral) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Lorazepam (oral) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Lorazepam (oral) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Lorazepam (oral) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Lorazepam (oral) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Lorazepam (oral) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Lorazepam (oral) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Lorazepam (oral) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Lorazepam (oral) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Lorazepam (oral) in patients who are immunocompromised.

Administration and Monitoring

Administration

• Oral

• Intravenous

Monitoring

There is limited information regarding Monitoring of Lorazepam (oral) in the drug label.

• Description

IV Compatibility

There is limited information regarding IV Compatibility of Lorazepam (oral) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Lorazepam (oral) in the drug label.

Pharmacology

There is limited information regarding Lorazepam (oral) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Lorazepam (oral)01.png

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Lorazepam (oral) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Lorazepam (oral) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Lorazepam (oral) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Lorazepam (oral) in the drug label.

How Supplied

Storage

There is limited information regarding Lorazepam (oral) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Lorazepam (oral) in the drug label.

Precautions with Alcohol

• Alcohol-Lorazepam (oral) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• LORAZEPAM®

Look-Alike Drug Names

• A® — B®

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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