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Impetigo

• Impetigo, adult

• Empiric antimicrobial therapy (covering methicillin-susceptible Staphylococcus aureus and β-hemolytic streptococci)

• Limited number of lesions

• Preferred regimen: Mupirocin topically bid for 5 days OR Retapamulin topically bid for 5 days

• Numerous lesions or outbreaks of post streptococcal glomerulonephritis

• Preferred regimen: Dicloxacillin 250 mg PO qid for 7 days OR Amoxicillin-Clavulanate 875/125 mg PO bid for 7 days OR Cephalexin 250 mg PO qid for 7 days
• Alternative regimen (for penicillin-allergic patients): Doxycycline 100 mg PO bid for 7 days OR Clindamycin 300–400 mg PO qid for 7 days OR Sulfamethoxazole-Trimethoprim 1–2 double-strength tablets PO bid for 7 days

• Culture-directed antimicrobial therapy

• Streptococcus alone

• Preferred regimen: Penicillin V 250–500 mg PO qid for 7 days
• Alternative regimen (for penicillin-allergic patients): Erythromycin 250 mg PO qid for 7 days OR Clindamycin 300–400 mg PO qid for 7 days

• Methicillin-resistant Staphylococcus aureus

• Preferred regimen: Doxycycline 100 mg PO bid for 7 days OR Clindamycin 300–450 mg PO qid for 7 days OR Sulfamethoxazole-Trimethoprim 1–2 double-strength tablets PO bid for 7 days

• Ecthyma

• Empiric therapy Oral 7 days (MSSA)