Sandbox g12: Difference between revisions

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Gerald Chi- (talk | contribs)
Bureaucrats, bureaucrats, nocaptcha, oversight, smwadministrator, Administrators, Widget editors
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Line 2: Line 2:
:* '''Drugs with known TdP risk'''
:* '''Drugs with known TdP risk'''
::* [[Atazanavir|Atazanavir (Reyataz®)]]
::* [[Atazanavir|Atazanavir (Reyataz®)]]
::* [[Bosutinib|Bosutinib (Bosulif®)]]
::* [[Chlorpromazine|Chlorpromazine (Thorazine®, Largactil®, Megaphen®)]]
::* [[Cisapride (Removed from US Market)|Cisapride (Removed from US Market) (Propulsid®)]]
::* [[Epinephrine (Adrenaline)|Epinephrine (Adrenaline) (Primatene®, Bronkaid®)]]
::* [[Fingolimod|Fingolimod (Gilenya®)]]
::* [[Gemifloxacin|Gemifloxacin (Factive®)]]
::* [[Gemifloxacin|Gemifloxacin (Factive®)]]
::* [[Granisetron|Granisetron (Kytril®, Sancuso®, Granisol®)]]
::* [[Leuprolide (Leuprorelin)|Leuprolide (Leuprorelin) (Lupron®, Eligard®, Viadur®, Carcinil®, Enanton®, Leuplin®, Lucrin®, Procren®, Prostap® and others)]]
::* [[Mirtazapine|Mirtazapine (Remeron)]]
::* [[Pasireotide|Pasireotide (Signifor®)]]
::* [[Sorafenib|Sorafenib (Nexavar®)]]


:* '''Drugs with possible TdP risk'''
:* '''Drugs with possible TdP risk'''
Line 26: Line 16:


:* '''Drugs with conditional TdP risk'''
:* '''Drugs with conditional TdP risk'''
::* [[Albuterol (salbutamol)|Albuterol (salbutamol) (Proventil®, Ventolin®, Ventolin-HFA®, Accuneb®, Combivent®, Vospire-ER®, ProAir HFA®, Duoneb®)]]
::* [[Haloperidol|Haloperidol (Haldol® (US & UK), Aloperidin®, Bioperidolo®, Brotopon®, Dozic®, Duraperidol® (Germany), Einalon S®, Eukystol®, Halosten®, Keselan®, Linton®, Peluces®, Serenace®, Serenase®, Sigaperidol®)]]
::* [[Isoproterenol|Isoproterenol (Medihaler-Iso®, Isuprel®)]]
::* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
::* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
::* [[Methylphenidate|Methylphenidate (Ritalin®, Concerta®, Focalin®, Daytrana®, Methylin®, Metadate CD®)]]
::* [[Moexipril/HCTZ|Moexipril/HCTZ (Uniretic®, Univasc®)]]
::* [[Pimozide|Pimozide (Orap®)]]
::* [[Quetiapine|Quetiapine (Seroquel®)]]
::* [[Risperidone|Risperidone (Risperdal®)]]
::* [[Tacrolimus|Tacrolimus (Prograf®, Prograf®, Advagraf®, Protopic®)]]
::* [[Vemurafenib|Vemurafenib (Zelboraf®)]]


:* '''Drugs to be avoided by congenital Long QT'''
:* '''Drugs to be avoided by congenital Long QT'''

Revision as of 21:44, 31 May 2015

  • Risk categories for antimicrobial agents known to have an association with TdP[1]
  • Drugs with known TdP risk
  • Drugs with possible TdP risk
  • Drugs with conditional TdP risk
  • Drugs to be avoided by congenital Long QT
  • Torsades de pointes risk stratification schedules for antimicrobial agents[2]
  • Schedule I (Highest TdP risk, potent IKr blockers, TdP risk >1%)
  • Not available
  • Schedule II (Significant risk for TdP, particularly when coadministered with CYP inhibitors, relatively potent IKr blockade)
  • Not available
  • Schedule III (Risk for TdP is described, IKr blockade, particularly when coadministered with CYP inhibitors)
  • Schedule IV (Minimal risk for TdP, case reports of TdP, mild IKr blockade, may have CYP interactions)
  • Schedule V (Questionable/minimal risk for QT interval prolongation/TdP)

References

  1. ↑ "Arizona Center for Education and Research on Therapeutics".
  2. ↑ Owens, Robert C. (2004). "QT prolongation with antimicrobial agents: understanding the significance". Drugs. 64 (10): 1091–1124. ISSN 0012-6667. PMID 15139788.
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