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| ====Bacteria – Atypical Organisms====
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| {{pathogen|Chlamydophila pneumoniae}}
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| :*1. '''Atypical pneumonia caused by Chlamydophila pneumoniae''' <ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref>
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| ::*1.1''' Adult'''
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| :::* Preferred regimen (1): [[Doxycycline]] 100 mg PO bid for 14-21 days
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| :::* Preferred regimen (2): [[Tetracycline]] 250 mg PO qid for 14-21 days
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| :::* Preferred regimen (3): [[Azithromycin]] 500 mg PO as a single dose, followed by 250 mg PO qd for 4 days
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| :::* Preferred regimen (4): [[Clarithromycin]] 500 mg PO bid for 10 days
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| :::* Preferred regimen (5): [[Levofloxacin]] 500 mg IV or PO qd for 7 to 14 days
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| :::* Preferred regimen (6): [[Moxifloxacin]] 400 mg PO qd for 10 days.
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| ::*1.2 '''Pediatric'''
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| :::* Preferred regimen (1):[[ Erythromycin]] suspension,PO 50 mg/kg/day for 10 to 14 days
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| :::* Preferred regimen (2):[[ Clarithromycin]] suspension, 15 mg/kg/day for 10 days
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| :::* Preferred regimen (3): [[Azithromycin ]]suspension, PO 10 mg/kg once on the first day, followed by 5 mg/kg qd daily for 4 days
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| :*2.'''Upper respiratory tract infection'''<ref>{{cite book | last = Bartlett | first = John | title = Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases | publisher = Jones and Bartlett Learning | location = Burlington, MA | year = 2012 | isbn = 978-1449625580 }}</ref>
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| ::* Bronchitis
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| :::* Antibiotic therapy for C. pneumoniae is not required.
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| ::* Pharyngitis
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| :::* Antibiotic therapy for C. pneumoniae is not required.
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| ::* Sinusitis
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| :::* Antibiotic therapy is advisable if symptoms remain beyond 7-10 days.*
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| {{pathogen| Chlamydia trachomatis}}
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| :*1 '''Chlaymydial infections ''' '<ref>{{Cite journal| issn = 1545-8601| volume = 64| issue = RR-03| pages = 1–137| last1 = Workowski| first1 = Kimberly A.| last2 = Bolan| first2 = Gail A.| title = Sexually transmitted diseases treatment guidelines, 2015| journal = MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control| date = 2015-06-05| pmid = 26042815}}</ref>
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| ::*1.1 '''Chlamydial Infections in Adolescents and Adults'''
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| :::* Preferred regimen : [[Doxycycline]] 100 mg PO bid for 7 days {{or}} [[Azithromycin]] 1 g PO in a single dose
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| :::* Alternative regimen (1): [[ Erythromycin]] base 500 mg PO qid for 7 days {{or}} [[Erythromycin]] ethylsuccinate 800 mg PO qid for 7 days
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| :::* Alternative regimen (2): [[Levofloxacin]] 500 mg PO qd for 7 days {{or}} [[Ofloxacin]] 300 mg PO bid for 7 days.
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| :::* Note: Patients should be instructed to refer their sex partners for evaluation, testing, and treatment if they had sexual contact with the patient during the 60 days preceding onset of the patient's symptoms or chlamydia diagnosis.
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| ::*1.2 '''Chlamydial Infections in patients with HIV Infection'''
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| :::* Preferred regimen : [[Doxycycline]] 100 mg PO bid for 7 days {{or}} [[Azithromycin]] 1 g PO in a single dose
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| :::* Alternative regimen (1): [[ Erythromycin]] base 500 mg PO qid for 7 days {{or}} [[Erythromycin]] ethylsuccinate 800 mg PO qid for 7 days
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| :::* Alternative regimen (2): [[Levofloxacin]] 500 mg PO qd for 7 days {{or}} [[Ofloxacin]] 300 mg PO bid for 7 days.
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| ::*1.3'''Pregancy'''
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| :::* Preferred regimen :[[Azithromycin]] 1 g PO in a single dose
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| :::* Alternative regimen (1):[[ Amoxicillin]] 500 mg PO tid for 7 days
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| :::* Alternative regimen (2):[[ Erythromycin]] base 500 mg PO qid for 7 days {{or}} [[Erythromycin]]base 250 mg PO qid for 14 days
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| :::* Alternative regimen (3):[[ Erythromycin]] ethylsuccinate 800 mg PO qid for 7 days {{or}} [[Erythromycin]] ethylsuccinate 400 mg PO four qid for 14days
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| :::* Note:[[ Doxycycline]], [[Ofloxacin]], and [[Levofloxacin]] are contraindicated in pregnant women
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| :::* 1.4 '''Management of sex partners'''
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| :::* Preferred regimen : [[Doxycycline]] 100 mg PO bid for 7 days {{or}} [[Azithromycin]] 1 g PO in a single dose
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| :::* Alternative regimen (1): [[ Erythromycin]] base 500 mg PO qid for 7 days {{or}} [[Erythromycin]] ethylsuccinate 800 mg PO qid for 7 days
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| :::* Alternative regimen (2): [[Levofloxacin]] 500 mg PO qd for 7 days {{or}} [[Ofloxacin]] 300 mg PO bid for 7 days.
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| :::::: Note (1): Recent sex partners (i.e., persons having sexual contact with the infected patient within the 60 days preceding onset of symptoms or Chlamydia diagnosis) should be referred for evaluation, testing, and presumptive dual treatment.
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| :::::: Note (2): If the patient’s last potential sexual exposure was >60 days before onset of symptoms or diagnosis, the most recent sex partner should be treated.
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| :::::: Note (3): To avoid reinfection, sex partners should be instructed to abstain from unprotected sexual intercourse for 7 days after they and their sexual partner(s) have completed treatment and after resolution of symptoms, if present
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| ::*2 '''Chlamydial infection among neonates'''
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| ::*2.1 '''Ophthalmia Neonatorum'''caused by ''C. trachomatis''
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| :::* Preferred regimen :[[ Erythromycin]] base or ethylsuccinate ,PO 50 mg/kg/ day divided into 4 doses daily for 14 days
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| :::* Alternative regimen : [[Azithromycin ]]suspension, PO 20 mg/kg /day qd for 3 days
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| :::* Note: The mothers of infants who have chlamydial infection and the sex partners of these women should be evaluated and treated.
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| ::*2.2'''Infant Pneumonia'''
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| :::* Preferred regimen :[[ Erythromycin]] base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days
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| :::* Alternative regimen : [[Azithromycin ]]suspension, PO 20 mg/kg /day qd for 3 days
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| ::*3.'''Chlamydial infection among infants and childern'''
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| ::*3.1 Infants and childern who weigh < 45 kg
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| :::* Preferred regimen :[[ Erythromycin]] base or ethylsuccinate PO 50 mg/kg/ day divided into 4 doses daily for 14 days
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| ::*3.2 Infants and childern who weigh ≥45 kg but who are aged <8 years
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| :::* Preferred regimen :[[Azithromycin]] 1 g PO in a single dose
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| ::*3.3 Infants and childern aged ≥8 years
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| :::* Preferred regimen :[[Azithromycin]] 1 g PO in a single dose {{or}} [[Doxycycline]] 100 mg PO bid for 7 days
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| * '''Lymphogranuloma venereum (LGV) '''
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| :* Lymphogranuloma venereum (LGV) is caused by C. trachomatis serovars L1, L2, or L3 '<ref>{{Cite journal| issn = 1545-8601| volume = 64| issue = RR-03| pages = 1–137| last1 = Workowski| first1 = Kimberly A.| last2 = Bolan| first2 = Gail A.| title = Sexually transmitted diseases treatment guidelines, 2015| journal = MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control| date = 2015-06-05| pmid = 26042815}}</ref>
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| :::* Preferred regimen : [[Doxycycline]] 100 mg PO bid for 21 days
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| :::* Alternative regimen: [[ Erythromycin]] base 500 mg PO qid for 21 days
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| ::: Note (1): [[azithromycin]] 1 g orally once weekly for 3 weeks is probably effective based on its chlamydial antimicrobial activity. Fluoroquinolone-based treatments might also be effective, but extended treatment intervals are likely required.
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| ::: Note (2): Pregnant and lactating women should be treated with [[erythromycin]]. [[Azithromycin]] might prove useful for treatment of LGV in pregnancy, but no published data are available regarding its safety and efficacy. [[Doxycycline]] is contraindicated in pregnant women.
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| ::: Note (3): Persons with both LGV and HIV infection should receive the same regimens as those who are HIV negative. Prolonged therapy might be required, and delay in resolution of symptoms might occur.
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| ::: Note(4): Persons who have had sexual contact with a patient who has LGV within the 60 days before onset of the patient’s symptoms should be examined and tested for urethral, cervical, or rectal chlamydial infection depending on anatomic site of exposure. They should be presumptively treated with a chlamydia regimen ( [[Azithromycin]] 1 g PO single dose {{or}} [[Doxycycline]] 100 mg PO bid for 7 days).
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| {{pathogen|Chlamydophila psittaci}}
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| :*1. '''Pneumonia'''<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref>
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| ::*1.1 '''Adult'''
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| :::* Preferred regimen : [[Doxycycline]] 100 mg PO bid daily {{or}} [[Tetracycline]] 500 mg PO qid for 10-21 days
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| :::* Alternative regimen :[[Minocycline]]
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| ::*1.2 '''Pediatric '''
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| :::* Preferred regimen: [[Azithromycin ]]
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| :::* Alternative regimen: fluoroquinolones
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| ::*1.3 '''Pregnant Patients'''
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| :::* Preferred regimen : [[Azithromycin ]]
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| :::* Alternative regimen: fluoroquinolones
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| ::*2.'''Endocarditis in valve replacement patients'''
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| :::* Preferred regimen : [[Doxycycline]]
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| :::* Alternative regimen : fluoroquinolones.
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| <references/>
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| {{Reflist}}
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| ''' '<ref>{{Cite journal| issn = 1545-8601| volume = 64| issue = RR-03| pages = 1–137| last1 = Workowski| first1 = Kimberly A.| last2 = Bolan| first2 = Gail A.| title = Sexually transmitted diseases treatment guidelines, 2015| journal = MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control| date = 2015-06-05| pmid = 26042815}}</ref>
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| | External Anogenital Warts (i.e., penis, groin, scrotum, vulva, perineum, external anus, and perianus) |
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| External Anogenital Warts (i.e., penis, groin, scrotum, vulva, perineum, external anus, and perianus)
| | :::* Preferred regimen :Patient-Applied:[[Imiquimod]] 3.75% or 5% cream {{or}}[[Podofilox]] 0.5% solution or gel {{or}} [[Sinecatechins]] 15% ointment |
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| :::* Preferred regimen :Patient-Applied:[[Imiquimod]] 3.75% or 5% cream {{or}}[[Podofilox]] 0.5% solution or gel {{or}} Sinecatechins 15% ointment | | :::* Preferred regimen :Provider-Administered: Cryotherapy with liquid nitrogen or cryoprobe {{or}} Surgical removal either by tangential scissor excision, tangential shave excision, curettage, laser,orelectrosurgery {{or}} [[Trichloroacetic acid]] (TCA) or [[Bichloroacetic acid]] (BCA) 80%–90% solution |
| Recommended Regimens for External Anogenital Warts (i.e., penis, groin, scrotum, vulva, perineum, external anus, and perianus*)
| | :::Note(1):Many persons with external anal warts also have intra-anal warts. Thus, persons with external anal warts might benefit from an inspection of the anal canal by digital examination, standard anoscopy, or high-resolution anoscopy. |
| :::* Preferred regimen :Provider–Administered: Cryotherapy with liquid nitrogen or cryoprobe ORSurgical removal either by tangential scissor excision, tangential shave excision, curettage, laser,o relectrosurgeryORTrichloroacetic acid (TCA) or bichloroacetic acid (BCA) 80%–90% solution
| | :::Note(2):Might weaken condoms and vaginal diaphragms. |
| *Many persons with external anal warts also have intra-anal warts. Thus, persons with external anal warts might benefit from an inspection of the anal canal by digital examination, standard anoscopy, or high-resolution anoscopy.
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| Might weaken condoms and vaginal diaphragms. | |