Sandbox carlos: Difference between revisions
Jump to navigation
Jump to search
Carlos Lopez (talk | contribs) No edit summary |
Carlos Lopez (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
::* 1.Primary pulmonary in pts with increased risk of complications or dissemination. | ::* 1.Primary pulmonary in pts with increased risk of complications or dissemination. | ||
:::Mild to moderate severity: | |||
:::Itraconazole solution 200 mg po or IV bid OR | |||
:::Fluconazole 400 mg po q24h for 3–12 mo | |||
::* Locally severe or disseminated disease: | |||
Ampho B 0.6–1 mg/kg per day x 7 days then 0.8 mg/kg every other day or liposomal ampho B 3-5 mg/kg/d IV or ABLC 5 mg/kg/d IV, until clinical improvement (usually several wks or longer in disseminated disease), followed by itra or flu for at least 1 year. | |||
::* Meningitis: | |||
:::* Preferred regimen: Fluconazole 400–1,000 mg po q24h indefinitely | |||
:::* Alternative regimen: Ampho B IV as for pulmonary (above) + 0.1–0.3 mg daily intrathecal (intraventricular) via reservoir device. OR itra 400–800 mg q24h OR voriconazole | |||
Some use combination of Ampho B & Flu for progressive severe | |||
disease; controlled series lacking. | |||
==References== | ==References== | ||
{{reflist}} | {{reflist}} | ||
Revision as of 15:35, 21 July 2015
- Coccidioidomycosis
Return to Top
- 1.Primary pulmonary in pts with increased risk of complications or dissemination.
:::Mild to moderate severity:
- Itraconazole solution 200 mg po or IV bid OR
- Fluconazole 400 mg po q24h for 3–12 mo
- Locally severe or disseminated disease:
Ampho B 0.6–1 mg/kg per day x 7 days then 0.8 mg/kg every other day or liposomal ampho B 3-5 mg/kg/d IV or ABLC 5 mg/kg/d IV, until clinical improvement (usually several wks or longer in disseminated disease), followed by itra or flu for at least 1 year.
- Meningitis:
- Preferred regimen: Fluconazole 400–1,000 mg po q24h indefinitely
- Alternative regimen: Ampho B IV as for pulmonary (above) + 0.1–0.3 mg daily intrathecal (intraventricular) via reservoir device. OR itra 400–800 mg q24h OR voriconazole
Some use combination of Ampho B & Flu for progressive severe
disease; controlled series lacking.
==References==